Xerostomia,Medicine, Persian traditional,Hollyhocks,Common mallow,Cancer," /> Xerostomia,Medicine, Persian traditional,Hollyhocks,Common mallow,Cancer,"/> Efficacy of a traditional Persian medicine preparation for radiation-induced xerostomia: A randomized, open-label, active-controlled trial
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Journal of Integrative Medicine ›› 2017, Vol. 15 ›› Issue (3): 201-208.doi: 10.1016/S2095-4964(17)60333-9

• Research Article • Previous Articles     Next Articles

Efficacy of a traditional Persian medicine preparation for radiation-induced xerostomia: A randomized, open-label, active-controlled trial

Ghazaleh Heydarirada, Hossein Rezaeizadehb, Rasool Choopania, Seyed Hamdollah Mosavatc,d, Ahmad Amerie   

  1. a Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran 15167-45811, Iran;
    b Department of Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Science,Tehran 16687-53961, Iran;
    c Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz 71356-44144, Iran;
    d Essence of Parsiyan Wisdom Institute, Traditional Medicine and Medicinal Plant Incubator, Shiraz University of Medical Sciences, Shiraz 71356-44144, Iran;
    e Department of Radiation Oncology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran 19946-15611, Iran
  • Received:2016-10-22 Accepted:2017-02-06 Online:2017-05-15 Published:2017-05-15
  • Contact: Seyed Hamdollah Mosavat, Assistant Professor, MD, PhD; E-mail: hamdi_88114@yahoo.com

Background

Xerostomia is one of the most common side effects of radiation therapy among patients with head and neck cancers (HNC). However, conventional medicine lacks an effective treatment for radiation-induced xerostomia.

Objective

Synthesizing the traditional use of Alcea digitata and Malva sylvestris with their known beneficial effects from recent studies, we evaluated the efficacy of the herbs in the quality of life (QOL) of HNC patients with radiation-induced xerostomia.

Design, Setting, Participants and Interventions

This study is a randomized, double-arm, open-label active-controlled clinical trial. We evaluated the effect of A. digitata and M. sylvestris on QOL of HNC patients with radiation-induced xerostomia compared with Hypozalix (artificial saliva). Patients were enrolled from the Imam Hossein Hospital's oncology clinic in Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Main Outcome Measures

Primary outcome measures in this trial were changes in patients' QOL assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Head and Neck Module (EORTC QLQ-H&N 35).

Results

Between-group analysis showed that the intervention group patients obtained significantly lower (better) total EORTC QLQ-H&N 35 scores as compared to the control group at the end of the intervention period (P = 0.007). Mean scores of dry mouth of EORTC QLQ-H&N 35 was also significantly lower (better) in the intervention group as compared to the control group (P = 0.017).

Conclusion

Traditional Persian medicine preparation of hollyhocks and common mallow should be considered as a suitable treatment for xerostomia and improving QOL in HNC patients with radiation-induced xerostomia.

Trial registration

The trial was registered in ClinicalTrials.gov with Identifier: NCT02854358.

Key words: Xerostomia, Medicine, Persian traditional, Hollyhocks, Common mallow, Cancer

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