This article briefly reviews and discusses the current status of major non-communicable diseases (mNCDs), definition of e-noise, its possible link as a risk factor for cardiovascular diseases and other mNCDs, and proposes possible mechanisms and hypotheses on that link, and how to control e-noise in the future. E-noise is defined as signal from electronic products and instruments that emit radiation and electromagnetic fields. It includes not only the acoustic but also non-acoustic noise. Just like road traffic and aircraft noises, e-noise may not only lead to hearing loss and health problems such as fatigue, stress, irritability, headache, and insomnia, but may also endanger cardiovascular health and result in hypertension, ischemic heart disease (myocardial infarction), arrhythmia (atrial fibrillation) and stroke; brain and metabolic problems such as obesity and diabetes; mental and cognitive impairment; as well as changing of humans’ long-evolved cortisol and circadian rhythms after long-term exposure. Even short-term exposure to excessive e-noise may lead to heightened stress responses and low quality of life. In conclusion, e-noise is a potential danger in our world, and further studies are needed of its effects on mechanisms of aging, disease, and human health.