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Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (12): 1119-1123.doi: 10.3736/jcim20101203

Special Issue: Traditional Chinese Medicine

• Commentary • Previous Articles     Next Articles

Discussion on the main pathogenesis in traditional Chinese medicine and etiology about primary osteoporosis

 Xin-xiang Wang, Yun-ling Zhang, Qi-fu Huang   

  1. Experiment Center, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
  • Online:2010-12-20 Published:2010-12-15
  • Contact: Wang Xin-xiang E-mail:wangxinxiangcn@yahoo.com.cn

Osteoporosis is characterized by reduced bone mass and impaired micro-architectural structure, leading to an increased susceptibility to fractures. It is a complex, multifactorial disorder resulting from genetic factors, environmental factors and gene-environment interactions. Currently there are three opinions on the main pathogenesis of primary osteoporosis in traditional Chinese medicine: kidney deficiency, spleen deficiency, and spleen-kidney deficiency, in which disagreement remains. In this paper, the authors combine the modern etiology of osteoporosis to explain scientific connotation of the three opinions, aiming to comprehend the pathogenesis of primary osteoporosis and strengthen the communication between traditional Chinese medicine and Western medicine, and trying to evaluate the clinical curative effect on osteoporosis.

Key words: Osteoporosis, Kidney deficiency, Spleen deficiency, Genetic disease, Inborn, Disorders of environmental origin

[1] Piao JH, Pang LP, Liu ZH, Xiang Q, Su N, Pan ZA, Guo YC, Li FF, Li FG, Liu JP, Chen ZJ, Wang XM, Hu YW, Zhang YQ, Wang XH, Cheng XG. China population , the diagnostic criteria of primary osteoporosis and the incidence of osteoporosis in China .Zhongguo Gu Zhi Shu Song Za Zhi. 2002 ; 8(1) : 1-7. Chinese with abstract in English.
朴俊红, 庞莲萍, 刘忠厚, 向青, 苏南, 潘子昂, 郭亦超, 李芳芳, 李扶刚, 刘京萍, 陈仲景, 王晓敏, 扈英伟, 张燕晴, 王晓红, 程晓光 . 中国人口状况及原发性骨质疏松症诊断标准和发生率.中国骨质疏松杂志. 2002; 8(1) : 1-7.
[2] Liu ZH. Bone mineral and clinic. Beijing: Science and Technology of China Press. 2006: 237-249, 956-959. Chinese.
刘忠厚 . 骨矿与临床.北京: 中国科学技术出版社.2006: 237-249, 956-959.
[3] Ouyang G , Xie BH . Dealing with spleen and stomach in treatment of primary osteoporosis. Nanjing Zhong Yi Yao Da Xue Xue Bao Zi Ran Ke Xue Ban. 2000 ; 16(5):269-270. Chinese with abstract in English.
欧阳钢, 谢碧红 . 论原发性骨质疏松症从脾胃论治. 南京中医药大学学报(自然科学版). 2000; 16(5):269-270.
[4] Zhu XH, Zhao CH. Treatment of osteoporosis by dealing with spleen-stomach. Xin Zhong Yi. 2004 ; 36(12) : 3-4. Chinese.
朱小华, 赵仓焕 . 从脾胃论治骨质疏松症.新中医. 2004; 36(12) : 3-4.
[5] Wang XX, Zhang YL, Wang SJ. Osteoporosis and recognition of bone erosion by Li Dong-yuan. Beijing Zhong Yi Yao Da Xue Xue Bao. 2009; 32(7):446-449. Chinese with abstract in English.
王新祥, 张允岭, 王少杰 . 骨质疏松症与李东垣“骨蚀” 病的探讨. 北京中医药大学学报. 2009; 32(7):446-449.
[6] Lin JT, Wu T, Yu Q, Guo Z, Chen GB. Effect of Buzhongyiqi decoction on the mechanical parameters of mice with osteoporosis induced by cyclophosphamide. Zhongguo Zu Zhi Gong Cheng Yan Jiu Yu Lin Chuang KangFu. 2007; 11(6):1159-1161, 1164. Chinese with abstract in English.
林坚涛, 吴铁, 于琼, 郭震, 陈广斌 . 补中益气汤对环磷酰胺致骨质疏松小鼠骨生物力学的影响. 中国组织工程研究与临床康复. 2007; 11(6):1159-1161, 1164.
[7] Liu XQ, Cui L, Wu T, Tan DY,. Skeletal effects of ginseng on osteopenia in ovariectomized rats. Zhongguo Gu Zhi Shu Song Za Zhi. 2003 ; 9(4) : 304-307. Chinese with abstract in English.
刘晓青, 崔燎, 吴铁, 覃冬云 . 人参水煎剂防治去卵巢大鼠骨量丢失的骨形态计量学观察.中国骨质疏松杂志. 2003; 9(4) : 304-307.
[8] Li CY, Wu T, Huang LF, Liang NC, Mo A, Li QN. Effects of Huangqi ( Astragalus membranaceus)and DES on skeleton of ovariectomized rats. Zhong Cao Yao. 1998; 29(1):27-28. Chinese with abstract in English.
李朝阳, 吴铁, 黄连芳, 梁念慈, 莫艾, 李青南 . 黄芪水提液与己烯雌酚对去卵巢大鼠骨代谢的影响.中草药. 1998; 29(1):27-28.
[9] Wang XX, Zhang YL, Wu J, Chiba D, Yamada K , Ishimi Y. The effects of puerariae radix on bone mass and bone microarchitecture in ovariectomy mice. Zhongguo Gu Zhi Shu Song Za Zhi. 2008; 14(5):349-354. Chinese with abstract in English.
王新祥, 张允岭, 吴坚, 千叶大成, 山田和彦, 石见佳子 . 葛根对骨质疏松模型小鼠骨密度和骨组织形态的作用.中国骨质疏松杂志. 2008; 14(5):349-354.
[10] Wang XX, Zhang YL, Wu J, Chiba D, Yamada K, Ishimi Y. Effects of puerariae radix on bone density and bone microarchitecture in castrated mice with osteoporosis. Zhongguo Zhu Zi Gong Cheng Yan Jiu Yu Lin Chuang Kang Fu. 2010 ; 14(7):1262-1266. Chinese with abstract in English.
王新祥, 张允岭, 吴坚, 千叶大成, 山田和彦, 石见佳子 . 葛根对睾丸切除骨质疏松模型小鼠骨密度和骨构造的作用.中国组织工程研究与临床康复. 2010; 14(7):1262-1266.
[11] Li CM, Liu ZF, Li M, Gao YL, Han B , Liu K. The effects of Cimicifuga foetida extrcts on bone mass and bone microarchitecture in ovariectomy rats. Zhong Cao Yao. 2005; 36(11) : 1686-1688. Chinese.
李春梅, 刘志峰, 李敏, 髙永林, 韩兵, 刘珂 . 升麻提取物对去卵巢所致大鼠骨质疏松症的作用. 中草药. 2005; 36(11) : 1686-1688.
[12] Zhu YP . An exploratory on the therapeutic principle and ralated machanism of osteoporosis in traditional Chinese medicine. Zhong Yi Yao Lin Chuang Za Zhi. 2004; 16(6):589-590. Chinese.
朱运平 . 骨质疏松症从脾肾论治及相关机理探讨.中医药临床杂志. 2004; 16(6):589-590.
[13] Zhang H . The preventive and treatmental effects on osteoporosis using the methods of spleen-strengthening and kidney-tonifying in traditional Chinese herbal medicine. Shi Zhen Guo Yi Guo Yao. 2007 ; 18(9):2250. Chinese.
张红 . 从补肾健脾法谈中医药对骨质疏松症的防治. 时珍国医国药. 2007; 18(9):2250.
[14] Luo J, Hu YS, Wu Y , Sun LM. Clinical study on osteoporosis using the traditional Chinese herbal medicine of spleen-strengthening and kidney-tonifying. Zhongguo Kang Fu Yi Xue Za Zhi. 2007; 22(10):923-924. Chinese.
罗娟, 胡永善, 吴毅, 孙莉敏 . 补肾健脾中药治疗骨质疏松症疗效观察.中国康复医学杂志. 2007; 22(10):923-924.
[15] Luo XL, Zhong ZR, Jiang B , Huang P . Clinical study on 69 postmenopausal osteoporosis using traditional Chinese herbal medicine of spleen-strengthening and kidney-tonifying. Yi Xue Li Lun Yu Shi Jian. 2008 ; 2008; 21(1) : 64-65. Chinese.
罗小玲, 钟紫茹, 江波, 黄平 . 健脾补肾方药对绝经后妇女骨质疏松症69例临床观察.医学理论与实践. 2008; 21(1) : 64-65.
[16] Wen F , Ju Y. Clinical study on 81 middle and eldly peoples with thoracolumbar vertebrae osteoporosis using traditional Chinese herbal medicine by the methods of spleen-strengthening and kidney-tonifying. Shi Yong Zhong Yi Nei Ke Za Zhi. 2008; 22(5): 49, 72. Chinese.
文锋, 鞠洋 .补肾健脾法治疗中老年胸腰椎骨质疏松症 89例 .实用中医内科杂志. 2008; 22(5): 49, 72.
[17] Li YS, Tong PJ, Ma HZ, Ma ZC , Chen JJ . Effects of spleen-strengthening and kidney-tonifying traditional Chinese herbal medicine on osteoporosis in aged rats. Zhongguo Gu Zhi Shu Song Za Zhi. 2003; 9(2):167-170. Chinese with abstract in English.
李涯松, 童培建, 马红珍, 马镇川, 陈俊杰 . 健脾补肾方药对老龄大鼠骨质疏松防治作用的实验研究.中国骨质疏松杂志. 2003; 9(2):167-170.
[18] Kung AW, Huang QY . Genetic and environmental determinants of osteoporosis.[J] Musculoskelet Neuronal Interact. 2007; 7(1):26-32.
[19] Ferrari S . Human genetics of osteoporosis. Best Pract Res Clin Endocrinol Metab. 2008; 22(5) : 723-735.
doi: 10.1016/j.beem.2008.08.007
[20] Jiang YH, Bressler J, Beaudet AL . Epigenetics and human disease. Annu Rev Genomics Hum Genet. 2004 ; 5:479-510.
doi: 10.1146/annurev.genom.5.061903.180014
[21] Hunter DJ . Gene-environment interactions in human diseases. Nat Rev Genet. 2005; 6(4):287-298.
[22] Godfrey KM, Lillycrop KA, Burdge GC, Gluckman PD, Hanson MA . Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatr Res. 2007; 61(5 Pt 2) : 5R-10R.
doi: 10.1203/pdr.0b013e318045bedb
[23] Zhang ZL. Osteoporosis and heredity. Zhongguo Quan KeYiXue . 2007; 10(22) : 1849-1851. Chinese.
章振林 . 骨质疏松与遗传.中国全科医学. 2007; 10(22) : 1849-1851.
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