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Journal of Integrative Medicine ›› 2020, Vol. 18 ›› Issue (1): 1-13.doi: 10.1016/j.joim.2019.11.004

• Review •     Next Articles

Gastroprotective herbs for headache management in Persian medicine: A comprehensive review

Maryam Naeimia, Narjes Gorjib, Zahra Memarianib, Reihaneh Moeinib, Mohammad Kamalinejadc, Fatemeh Kolangid   

  1. a. Department of Persian Medicine, School of Persian Medicine, Babol University of Medical Sciences, Babol, 4717647745, Iran
    b. Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, 4717647745, Iran
    c. School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, 1985717443, Iran
    d. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, 4934174515, Iran

  • Online:2020-01-15 Published:2019-12-02
  • Contact: Narjes Gorji

The gut-brain axis is a bidirectional communication system that exists between the brain and gut. Several studies claimed that some types of headaches are associated with various gastrointestinal (GI) disorders. In Persian medicine (PM), physicians believed gastric disturbances could stimulate headache and introduced some herbs for boosting gastric function as a therapeutic remedy for headache. Here we review the current evidence for the gastroprotective and antiheadache effects of herbs used in PM. Herbs used for their gastrotonic effects in PM were identified from selected Persian medical and pharmaceutical textbooks. PubMed, Scopus and Google Scholar were used to search for contemporary scientific evidence relating to the gastric and neurologic effects of these plants. A total of 24 plants were recorded from the selected sources included in this review, most of which belonged to the Rosaceae family. Phyllanthus emblicaZingiber officinaleBoswellias errataPunica granatum and Hypericum perforatum had the most recent studies related to GI disorder and headache, while current research about quince, rose, apple, hawthorn and pear was limited. Reducing Helicobacter pylori growth, gastritis, erosion of the stomach lining, hemorrhage and perforation, improving gastric mucosal resistance, antisecretary, antiulcer, antipyretic, analgesic, sedative, anxiolytic, anti-inflammatory, anticonvulsant, neuroprotective and antioxidant effects as well as improvement in memory scores were some of the gastrotonic and neuroprotective mechanisms described in the current research. These results confirmed that medicinal plants prescribed in PM may improve headache in patients through the management of GI abnormalities. However, further studies are recommended to investigate the efficacy and safety of the mentioned medicinal plants.

Key words: Traditional medicine, Gastrointestinal diseases, Headache, Gastroprotective agent

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[11] Si-yu Shen , Xiao-dong Fu, Yong-wen Zhang, Xiao-lei Dong, Ling-jie Zhao , Hui Cai. Relationship between lupus headache and headache due to internal injury in traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2009, 7(5): 407-410.
[12] Jun-ying Fu. Current status of research on complementary and alternative medicine in the United States: in comparison with that on traditional Chinese medicine in China. Journal of Chinese Integrative Medicine, 2008, 6(6): 551-554.
[13] Xing Liao, Yan-ming Xie. Application of consensus methods in making clinical practice guidelines of traditional medicine. Journal of Chinese Integrative Medicine, 2008, 6(6): 555-560.
[14] Lei Fang, Min Fang, Yu-chao Liu. Research advances of traditional Chinese medicine therapy in treating sports fatigue. Journal of Chinese Integrative Medicine, 2008, 6(12): 1305-1310.
[15] Wei-qiong Hu, Si-wei Xu. Clinical observation on treatment of cervicogenic headache with tuina and acupuncture. Journal of Chinese Integrative Medicine, 2005, 3(4): 310-311.
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