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Journal of Integrative Medicine ›› 2014, Vol. 12 ›› Issue (4): 331-335.doi: 10.1016/S2095-4964(14)60038-8

• Review •     Next Articles

Three advantages of using traditional Chinese medicine to prevent and treat tumor

Chang-quan Linga, Xiao-qiang Yuea, Chen Linga,b   

  1. Changhai Hospital of Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433, China
    Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida 32611, USA
    Powell Gene Therapy Center, University of Florida College of Medicine, Gainesville, Florida 32611, USA
  • Received:2014-07-05 Accepted:2014-07-11 Online:2014-07-10 Published:2014-07-15

Traditional Chinese medicine (TCM), an important component of complementary and alternative medicine, has evolved over thousands of years with its own unique system of theories, diagnostics and therapies. TCM has been increasingly used in the last decades and become well known for its significant role in preventing and treating cancer. We believe that TCM possesses advantages over Western medicine in specific aspects at a certain stage of cancer treatment. Here we summarize the advantages of TCM from three aspects: preventing tumorigenesis; attenuating toxicity and enhancing the treatment effect; and reducing tumor recurrence and metastasis.

Key words: Traditional medicine, Chinese, Tumorigenesis, Tumor prevention and treatment, Tumor recurrence and metastasis

[1] Qian Y, Jin Y, Li Y, Li B , Lin CQ. Experimental study on mechanism of Ganfu Jian Granule inhibiting hepatocarcinogenesis induced with diethylnitrosamine in rats. Zhejiang Zhong Yi Xue Yuan Xue Bao. 2003; 27(2): 56-58. Chinese with abstract in English
[2] Li PW ) Clinical observation on inhibitory effect of “Liuwei Dihuang” pill (LWDH) on serious esophageal epithelium proliferation (report of 211 cases). Zhong Ri You Hao Yi Yuan Xue Bao. 1990; 4(3): 170-172. Chinese with abstract in English
[3] Su JZ, Guo JD, Yang LQ, Cheng PX, Zhang YF, Zhang LZ. A-L Fuzheng Granules in the management of atrophic chronic gastritis. In: Sun Y, Yu GQ. Chinese traditional medicine and Western medicine integration in the prevention and treatment of cancer. Beijing: PUMC and BMU Publishers [1995]: 188-192
[4] Zhu Y , Liu P. Action of Astragalus decoction on hepatic oval cells ( HOCs) differentiating to liver in cirrhotic rat. Zhong Xi Yi Jie He Gan Bing Za Zhi. 2012; 22(5): 293-295. Chinese with abstract in English
[5] Li QY, Guo ZZ, Deng X, Xu LM, Gao YQ, Zhang W, Wang XS, Xue DY, Lu YY, Liu P, Su SB . Curative effects of ZHENG-based Fuzheng-Huayu Tablet on hepatitis B caused cirrhosis related to CYP1A2 genetic polymorphism. Evid Based Complement Alternat Med. 2013; 2013:302131
[6] Gu J, Zhang Q, Xue D, Cai H, Xu L . A randomized controlled study of Fuzheng Huayu Capsule for prevention of esophageal variceal bleeding in patients with liver cirrhosis. Evid Based Complement Alternat Med. 2013; 2013:534960
[7] Svetlana Balkanov K, Sotirova T, Genadieva SS, Cevreska L, Stojanovik A, Balkanov T . Adverse effects of thalidomide administration, in patients with myeloma multiplex? Mater Sociomed. 2014; 26(2):134-136
doi: 10.5455/msm.
[8] Kubeš J, Vítek P, Dědečková K , Ondrová B. Very late effects of radiotherapy-limiting factor of current radiotherapy techniques.Klin Onkol. 2014; 27(3): 161-165. Czech
doi: 10.14735/amko2014161
[9] Liu M, Tan H, Zhang X, Liu Z, Cheng Y, Wang D, Wang F . Hematopoietic effects and mechanisms of Fufang Ejiao Jiang on radiotherapy and chemotherapy-induced myelosuppressed mice.[J] Ethnopharmacol. 2014; 152(3):575-584
doi: 10.1016/j.jep.2014.02.012
[10] Su XH. Clinical observation on Bazhen Huaji Decoction combined with chemotherapy on 28 cases of ovarian cancer.Neimenggu Zhong Yi Yao. 2013; 32(35): 57, 76. Chinese with abstract in English
[11] Lau C, Mooiman KD, Maas-Bakker RF, Beijnen JH, Schellens JH, Meijerman I . Effect of Chinese herbs on CYP3A4 activity and expression in vitro.[J] Ethnopharmacol. 2013; 149(2):543-549
doi: 10.1016/j.jep.2013.07.014
[12] Hou W , Zhou YM. Function of traditional Chinese medicine in cancer radiotherapy and its prospect. Shi Jie Ke Xue Ji Shu Zhong Yi Yao Xian Dai Hua. 2009; 11(5): 742-746. Chinese with abstract in English
[13] Sun Y . Clinical results of BRMs in malignant diseases. Eur[J] Cancer. 1991; 27:228
[14] Meng MB, Wen QL, Cui YL, She B, Zhang RM . Meta-analysis: traditional Chinese medicine for improving immune response in patients with unresectable hepatocellular carcinoma after transcatheter arterial chemoembolization. Explore (NY) 1995,7(1):37-43
[15] Tas D, Uncu D, Sendur MA, Koca N, Zengin N . Acupuncture as a complementary treatment for cancer patients receiving chemotherapy. Asian Pac[J] Cancer Prev. 2014; 15(7):3139-3144
[16] Cheon S, Zhang X, Lee IS, Cho SH, Chae Y, Lee H . Pharmacopuncture for cancer care: a systematic review. Evid Based Complement Alternat Med. 2014; 2014:804746
[17] Bao T, Goloubeva O, Pelser C, Porter N, Primrose J, Hester L, Sadowska M, Lapidus R, Medeiros M, Lao L, Dorsey SG , Badros AZ. A pilot study of acupuncture in treating bortezomib-induced peripheral neuropathy in patients with multiple myeloma. Integr Cancer Ther. 2014; Epub ahead of print
[18] Pan CX, Morrison RS, Ness J, Fugh-Berman A, Leipzig RM . Complementary and alternative medicine in the management of pain, dyspnea, and nausea and vomiting near the end of life. A systematic review.[J] Pain Symptom Manage. 2000; 20(5):374-387
doi: 10.1016/S0885-3924(00)00190-1
[19] Ezzo J, Vickers A, Richardson MA, Allen C, Dibble SL, Issell B, Lao L, Pearl M, Ramirez G, Roscoe JA, Shen J, Shivnan J, Streitberger K, Treish I, Zhang G . Acupuncture-point stimulation for chemotherapy-induced nausea and vomiting.[J] Clin Oncol. 2005; 23(28):7188-7198
doi: 10.1200/JCO.2005.06.028
[20] Yang J, Zhu L, Wu Z , Wang Y. Chinese herbal medicines for induction of remission in advanced or late gastric cancer.Cochrane Database Syst Rev. 2013; 4: CD005096
[21] Meng Z, Garrett CR, Shen Y, Liu L, Yang P, Huo Y, Zhao Q, Spelman AR, Ng CS, Chang DZ, Cohen L . Prospective randomised evaluation of traditional Chinese medicine combined with chemotherapy: a randomised phase II study of wild toad extract plus gemcitabine in patients with advanced pancreatic adenocarcinomas. Br[J] Cancer. 2012; 107(3):411-416
doi: 10.1038/bjc.2012.283
[22] Guo H, Liu JX, Xu L, Madebo T, Baak JP . Traditional Chinese medicine herbal treatment may have a relevant impact on the prognosis of patients with stage IV adenocarcinoma of the lung treated with platinum-based chemotherapy or combined targeted therapy and chemotherapy. Integr Cancer Ther[2011]; 10(2):127-137
doi: 10.1177/1534735410387599
[23] Li X, Yang G, Li X, Zhang Y, Yang J, Chang J, Sun X, Zhou X, Guo Y, Xu Y, Liu J, Bensoussan A . Traditional Chinese medicine in cancer care: a review of controlled clinical studies published in Chinese. PLoS One. 2013; 8(4):e60338
doi: 10.1371/journal.pone.0060338
[24] Sun Y . The role of Chinese medicine in clinical oncology.Chin[J] Integr Med. 2014; 20(1):3-10
[25] Zheng HG, Piao BK. Discussion of TCM etipathogenisis of the toxic and side effects of radiotherapy and chemotherapy.Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi. 2007; 13(10): 751-752. Chinese
[26] Lin JZ, Wang CJ. The strategy of tumor dormancy treatment on postoperative recurrence and metastasis. Guangdong Yi Xue . 2013; 34(1): 157-158. Chinese
[27] Ling CQ. Problems in cancer treatment and major research of integrative medicine.J Chin Integr Med 2003; 1(3):168-170. Chinese with abstract in English
doi: 10.3736/jcim
[28] Tang ZY. Destroying and restructuring simultaneously. Shanghai: Shanghai Scientific and Technical Publishers . 2011. Chinese
[29] Deng LJ, Hu LP, Peng QL, Yang XL, Bai LL, Yiu A, Li Y, Tian HY, Ye WC, Zhang DM . Hellebrigenin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Chem Biol Interact[2014]; 219C:184-194
[30] Wang H, Wu C, Wan S, Zhang H, Zhou S, Liu G . Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway. Toxicology. 2013; 308:104-112
doi: 10.1016/j.tox.2013.03.015
[31] Chen Y, Zheng L, Liu J, Zhou Z, Cao X, Lv X, Chen F . Shikonin inhibits prostate cancer cells metastasis by reducing matrix metalloproteinase-2/-9 expression via AKT/mTOR and ROS/ERK1/2 pathways. Int Immunopharmacol. 2014; 21(2):447-455
doi: 10.1016/j.intimp.2014.05.026
[32] Chen H, Shen A, Zhang Y, Chen Y, Lin J, Lin W, Sferra T, Peng J . Pien Tze Huang inhibits hypoxia-induced epithelialmesenchymal transition in human colon carcinoma cells through suppression of the HIF-1 pathway. Exp Ther Med[2014]; 7(5):1237-1242
doi: 10.3892/etm.2014.1549
[33] Zhang J, Wang P, Ouyang H, Yin J, Liu A, Ma C, Liu L . Targeting cancer-related inflammation: Chinese herbal medicine inhibits epithelial-to-mesenchymal transition in pancreatic cancer. PLoS One. 2013; 8(7):e70334
doi: 10.1371/journal.pone.0070334
[34] Jia B , Ye LH. Research on the mechanism of TCM therapy on tumor metastasis. Zhong Liu Fang Zhi Yan Jiu. 2013; 40(6): 620-623.
[35] Chen Z, Chen LY, Wang P, Dai HY, Gao S, Wang K . Tumor microenvironment varies under different TCM ZHENG models and correlates with treatment response to herbal medicine. Evid Based Complement Alternat Med. 2012; 2012:635702
[36] Li BH, Xiong MN, Zhou YP, Huang ZM, Li ZP, Cai Y, Long H .Clinical and experimental research on Bufei Xiaoji Decoction on non-small-cell lung cancer metastasis. Shi Yong Zhong Xi Yi Jie He Lin Chuang. 2003; 3(3): 1-2, 56. Chinese with abstract in English
[37] Ma J, Wang GH, Cai DF, Fan Y , Gu XX. Clinical observation of Jianpi Xiaoliu Decoction in preventing postoperative colorectal carcinoma recurrence and metastasis. Shanghai Zhong Yi Yao Za Zhi. 2005; 39(1): 24-25. Chinese with abstract in English
[38] Luo L, Yang YF, Li PH, Wu Y, Zhang JW, Wu XW, Gao SD , Liu DQ. Cohort study on Fuzheng Capsule and Quxie Capsule in reducing relapse and metastasis of cancer in patients with stage II and III colorectal carcinoma after operation. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006; 26(8): 677-680. Chinese with abstract in English
[39] Qiu YQ, Li XP, Meng L, Huang J , Chen M. The study of Sijunzi Decoction in preventing postoperative recurrence of superficial bladder cancer. Zhong Yi Yao Lin Chuang Za Zhi. 2012; 24(9): 875-876. Chinese
[40] Li ZP, Zeng JQ , Hu AM. Clinical study on the qi and xue dual-supply therapy with chemotherapy to prevent the recurrence and metastasis from colorectal carcinoma. Shi Yong Ai Zheng Za Zhi. 2010; 25(6): 618-620. Chinese with abstract in English
[41] Sun TZ, Yang F , Wang X. The clinical observation on Jianpi Jiedu Decoction in preventing metastasis after radical operation of gastric cancer. Xin Zhong Yi. 2011; 43(10): 82-83. Chinese
[42] Zhai XF, Chen Z, Li B, Shen F, Fan J, Zhou WP, Yang YK, Xu J, Qin X, Li LQ, Ling CQ . Traditional herbal medicine in preventing recurrence after resection of small hepatocellular carcinoma: a multicenter randomized controlled trial.[J] Integr Med. 2013; 11(2):90-100
doi: 10.3736/jintegrmed2013021
[43] Xie J, Shao J, Lu Y, Chen J, Wang J, Yu S, Jia L . Separation of ginseng active ingredients and their roles in cancer metastasis supplementary therapy. Curr Drug Metab. 2013; 14(5):616-623.
doi: 10.2174/13892002113149990003
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