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Journal of Integrative Medicine ›› 2020, Vol. 18 ›› Issue (5): 416-424.doi: 10.1016/j.joim.2020.07.004

• Original Chinical Research • Previous Articles     Next Articles

Alleviative effects of Cannabis flower on migraine and headache

Sarah S. Stitha, Jegason P. Diviantb, Franco Brockelmanc, Keenan Keelingc, Branden Hallc, Storri Lucernb, Jacob M. Vigild   

  1. a. Department of Economics, Faculty of Economics, University of New Mexico, Albuquerque, New Mexico 87131, USA
    b. Department of Psychology, Student of Psychology, University of New Mexico, Albuquerque, New Mexico 87131, USA
    c. Morebetter Ltd. Software Developer, Hyattsville, Maryland 20781, USA
    d. Department of Psychology, Faculty of Psychology, University of New Mexico, Albuquerque, New Mexico 87131, USA

  • Received:2019-10-26 Accepted:2020-04-01 Online:2020-09-10 Published:2020-10-08
  • Contact: Jacob M. Vigil
  • About author:Sarah S. Stith, Jegason P. Diviant, Franco Brockelman, Keenan Keeling, Branden Hall, Storri Lucern, Jacob M. Vigil

Objective: Few studies to date have measured the real-time effects of consumption of common and commercially available Cannabisproducts for the treatment of headache and migraine under naturalistic conditions. This study examines, for the first time, the effectiveness of using dried Cannabis flower, the most widely used type of Cannabis product in the United States, in actual time for treatment of headache- and migraine-related pain and the associations between different product characteristics and changes in symptom intensity following Cannabis use.
Methods: Between 06/10/2016 and 02/12/2019, 699 people used the Releaf Application to record real-time details of their Cannabisuse, including product characteristics and symptom intensity levels prior to and following self-administration; data included 1910 session-level attempts to treat headache- (1328 sessions) or migraine-related pain (582 sessions). Changes in headache- or migraine-related pain intensity were measured on a 0-10 scale prior to, and immediately, following Cannabis consumption.
Results: Ninety-four percent of users experienced symptom relief within a two-hour observation window. The average symptom intensity reduction was 3.3 points on a 0-10 scale (standard deviation = 2.28, Cohen’s d = 1.58), with males experiencing greater relief than females (P < 0.001) and a trend that younger users (< 35 years) experience greater relief than older users (P = 0.08). Mixed effects regression models showed that, among the known (i.e., labeled) product characteristics, tetrahydrocannabinol levels 10% and higher are the strongest independent predictors of symptom relief, and this effect is particularly prominent in headache rather than migraine sufferers (P < 0.05), females (P < 0.05) and younger users (P < 0.001). Females and younger users also appear to gain greater symptom relief from flower labeled as “C. indica” rather than “C. sativa” or other hybrid strains. 
Conclusion: These results suggest that whole dried Cannabis flower may be an effective medication for treatment of migraine- and headache-related pain, but the effectiveness differs according to characteristics of the Cannabis plant, the combustion methods, and the age and gender of the patient. 

Key words: Migraine, Headache, Cannabis, Marijuana, Symptom management

[1] Maryam Naeimia, Narjes Gorjib, Zahra Memarianib, Reihaneh Moeinib, Mohammad Kamalinejadc, Fatemeh Kolangid. Gastroprotective herbs for headache management in Persian medicine: A comprehensive review. Journal of Integrative Medicine, 2020, 18(1): 1-13.
[2] Si-yu Shen , Xiao-dong Fu, Yong-wen Zhang, Xiao-lei Dong, Ling-jie Zhao , Hui Cai. Relationship between lupus headache and headache due to internal injury in traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2009, 7(5): 407-410.
[3] Wei-qiong Hu, Si-wei Xu. Clinical observation on treatment of cervicogenic headache with tuina and acupuncture. Journal of Chinese Integrative Medicine, 2005, 3(4): 310-311.
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