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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (1): 12-14.doi: 10.3736/jcim20030107

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Supplementing Qi and activating blood circulation in gene regulation of vascular smooth muscle cells

Jin-kun Wen(), Mei Han   

  1. Institute of Basic Medicine,Hebei Medical University,Shijiazhuang,Hebei Province 050017,China
  • Received:2003-02-27 Online:2003-03-20 Published:2018-10-19

According to the theory of traditional Chinese medicine, blood stasis is a main pathological mechanism in the development of vascular diseases.Supplementing Qi and activating blood circulation, as the therapeutic principle for the blood stasis, has been adapted.Studies demonstrated that the supplementing Qi and activating blood circulation recipe could regulate the expression of vasoactive peptides in vascular smooth muscle cells (VSMCs). The recipe inhibited the formation of neointima following arterial intimal lesions through down-regulating expression of proliferation-related genes and phenotypic modulation of VSMCs. The recipe also markedly inhibited the adhesion and migration of VSMCs and matrix remodelling by means of a mechanism that balances extracellular matrix turnover rate. The purpose of this review is to summarize the recent advances made in our understanding of new functions for the recipe in regulating VSMCs behaviours and their microenvironment relevant to vascular diseases and maintaining proper homeostasis.

Key words: supplementing Qi and activating blood circulation, vascular smooth muscle cell, gene regulating expression

CLC Number: 

  • R242
[1] 韩梅, 温进坤 . 滋补肝肾益气活血法治疗肾性高血压的实验研究[J]. 中国老年学杂志, 2001,21(4):244-246
[2] 黄文增, 张步延, 王晓君 , 等. 当归注射液对高血压患者血浆血栓素A2和前列环素的影响[J]. 中国中西医结合杂志, 1999,19(3):143-145
doi: 10.7661/CJIM.1999.3.143
[3] 韩梅, 温进坤 . 滋补肝肾、益气活血方药对血管平滑肌细胞增殖及相关基因表达的影响[J]. 中国中西医结合杂志, 1999,19(12):734-736
doi: 10.7661/CJIM.1999.12.734
[4] 徐浩, 史大卓, 陈可冀 , 等. 用血清药理学方法观察芎芍胶囊对兔胸主动脉平滑肌细胞增殖凋亡的影响[J]. 中国中西医结合杂志, 2000,20(10):757-760
doi: 10.7661/CJIM.2000.10.757
[5] 周秀霞, 温进坤, 韩梅 . 含活血化瘀中药血清对血管平滑肌细胞迁移相关基因表达的影响[J]. 河北医科大学学报, 2000,21(4):217
doi: 10.3969/j.issn.1007-3205.2000.04.009
[6] 刘虹彬, 温进坤, 韩梅 . 丹参对血管平滑肌细胞基质金属蛋白酶和骨桥蛋白基因表达及细胞增殖的影响[J]. 中国中西医结合杂志, 2002,22(10):764-766
doi: 10.3321/j.issn:1003-5370.2002.10.013
[7] 张梅, 温进坤, 韩梅 . IH764-3对TNF-α诱导的大鼠血管平滑肌细胞黏附分子CD54表达及其与单核细胞黏附的影响[J]. 中华中西医杂志, 2002,3(9):780-782
[8] 石缨, 温进坤 . 丹参对大鼠血管平滑肌细胞迁移的影响[J]. 心肺血管病杂志, 1999,18(3):216-218
doi: 10.3969/j.issn.1007-5062.1999.03.021
[9] 石缨, 温进坤 . 中药抑制血管平滑肌细胞增殖及迁移研究新进展[J]. 中国老年学杂志, 1999,19(6):379-381
[10] 柴锡庆, 温进坤, 韩梅 . 益气健脾中药对血管平滑肌细胞凋亡及凋亡相关基因表达的影响[J]. 中国中西医结合杂志, 2001,21(12):909-912
[11] .[ OTHER].杨长春, 温进坤, 韩梅 . 黄芪和当归防治血管再狭窄与抑制粘着斑激酶表达及活化有关[C]. 中国动脉硬化杂志, 2002, 10(会议专辑): 107.
[12] 杨长春, 温进坤, 韩梅 . 黄芪、当归对血管平滑肌细胞粘着斑激酶表达和细胞凋亡的影响[J]. 中国中西医结合杂志, 2003,23(2):201-203
doi: 10.7661/CJIM.2003.3.201
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