To investigate the efficacy of Qiangxin Mixture in patients with congestive heart failure (CHF).
Sixty cases of CHF were randomly divided into Qiangxin Mixture group (treatment group,n=30) and digoxin group (control group, n=30).The total clinical effective rate,integra of the symptoms of kidney deficiency, classification of functional capacity of the NewYork Heart Association (NYHA), and echocardiogram[ejection fraction (EF), cardiac output (CO), interventricular septal thickness (IVST), posterior wall thickness (PWT), left ventricular mass index (LVMI)] as well as the measurement of plasma endothelin, angiotensin II and atrial natriuretic peptide were observed in both groups.
The total clinical effective rate of Qiangxin Mixture group was 87%, and improvement was significantly observed in the Lee CHF score, classification of functional capacity of the NYHA, EF and CO（P<0.05,vs before treatment）,but no significant improvement in digoxin group (P>0.05). The integra of the symptoms of kidney deficiency, the levels of plasma ET, Ang II and ANP decreased significantly (P<0.01) vs before treatment and digoxin group respectively). IVST,PWT and LVMI were also reduced significantly（P <0.01)vs before treatment;P<0.05 vs digoxin group）.
The Qiangxin Mixture is effective in enhencing cardiac contraction,improving hemodynamics in the short-term and rectifying some indexes in the long-term,so it could postpone the processes of CHF. This mechanism may be related to decreasing the stimulating factors (angiotensin, endothelin) which trigger the cardiac remodeling, delaying or reversing the cardiac remodeling.