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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (1): 47-50.doi: 10.3736/jcim20030119

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Effect of Sorbaria sorbifolia extract on anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine

Xue-wu Zhang(), Quan Sun, Ming Jin, Chun-mei Piao, Lian-Hua Li   

  1. Department of Biochemistry & Molecular Biology,College of Medicine, Yanbian University,Yanji,Jilin Province 133000, China
  • Received:2003-03-07 Online:2003-03-20 Published:2018-10-19

Objective

To study the effect of Sorbaria sorbifolia extract on anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine.


Methods

Sorbaria sorbifolia was perfused into stomach of rats with DEN-induced precancerosis, then the biochemical indexes were investigated. The activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and the concentrations of malondialdehyde (MDA), glutathione (GSH) were investigated by colorimetric method.


Results

Sorbaria sorbifolia extract increased SOD, GSH-PX and decreased MDA, GSH levels in serum and liver homogenate.


Conclusion

Sorbaria sorbifolia extract significantly increased anti-oxidative activities in rats with precancerosis induced by diethylnitrosamine.

Key words: Sorbaria sorbifolia, precancerous condition, anti-oxidative activity

CLC Number: 

  • R785.7

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组别 n 血清(U/ml) 肝匀浆(U/mg pro) 肝细胞线粒体(U/mg pro)
正常组 12 131.4±38.9* 72.9±39.8* 153.4±56.1*
模型组 9 92.6±42.7 49.8±14.0 135.1±31.9
给药组 11 126.7±27.3* 61.3±6.7* 144.1±45.4*

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组别 n 血清(nmol/L) 肝匀浆(nmol/mg pro) 肝细胞线粒体(nmol/mg pro)
正常组 12 0.8±0.1* 1.0±0.2* 1.2±0.3*
模型组 9 1.1±0.1 1.5±0.1 1.6±0.2
给药组 11 0.8±0.1* 0.7±0.3* 0.9±0.4*

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组别 n 血清(mg/L) 肝匀浆(U/mg pro) 肝细胞线粒体(U/mg pro)
正常组 12 28.6±5.69* 35.7±9.15* 35.1±10.7*
模型组 9 16.2±3.69 26.2±5.69 15.4±1.9
给药组 11 16.8±6.17* 31.4±6.55* 36.2±16.4*

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组别 n 血清(mg/L) 肝匀浆(U/mg pro) 肝细胞线粒体(U/mg pro)
正常组 12 219.2±40.8* 26.3±4.2* 135.6±22.3*
模型组 9 148.9±23.3 19.4±3.2 96.5±23.1*
给药组 11 198.1±12.4* 27.4±5.2* 129.5±25.7*
[1] 江苏新医学院. 中药大辞典(第1版)[M]. 上海: 上海科学技术出版社, 1994,( 第1版):8
[2] 李亦秀, 张永春, 李文汉 . 中草药山高粱的抗缺氧作用的初步研究[J]. 哈医大学报, 1981,4(-): 1-3
[3] 张学武, 金海玲, 朴春梅 , 等. 珍珠梅对亚硝酸钠和四氯化碳所致肝损伤的保护作用[J]. 延边大学医学学报, 2001,24(3):186-189
[4] 金海玲, 张学武, 赵红 , 等. 珍珠梅提取物对四氯化碳所致大鼠急性肝损伤的保护作用[J]. 世界华人消化杂志, 2002,10(7):783-786
[5] 张学武, 金海玲, 赵红 , 等. 珍珠梅对四氯化碳致肝损伤大鼠自由基影响[J]. 中国中医药科技, 2001,8(6):373-374
doi: 10.3969/j.issn.1005-7072.2001.06.015
[6] 金海玲, 张学武, 朴春梅 , 等. 珍珠梅对小鼠S180肉瘤的抑制作用[J]. 延边大学医学学报, 2002,25(1):14-16
[7] Yin ZZ, Jin HL, Shen MH , et al. Inhibitory effect of BR on Den-induced precancerous hepatic foci and antioxidative activities in rats[J]. Chin J Cancer Res, 1999,11(3):169-173
doi: 10.1007/s11670-999-0004-0
[8] Iwamoto A, Egashira T, Takayama F , et al. Changes in free radical-related substances in plasma following ischemia-reperfusion in rat liver[J]. Pathophysiology, 2002,8(3):167-174
doi: 10.1016/S0928-4680(02)00010-X pmid: 12039648
[9] Angle MF, Zhang F, Rogers B , et al. Role of free radicals in necrosis of skin graft compromised with hematoma[J]. Ann Plast Surg, 2002,48(6):665-669
doi: 10.1097/00000637-200206000-00017 pmid: 12055439
[10] 郭维新, 刘明堂, 郑书勤 , 等. 胃癌患者SOD活性与LPO含量观察[J]. 癌症, 1993,12(2):115-117
[11] 李文惠, 陈卫, 李亢宗 , 等. 肿瘤患者血GSH-PX活性变化的研究[J]. 肿瘤防治研究, 1995,22(3):159-161
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