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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (2): 142-145.doi: 10.3736/jcim20030218

Special Issue: Traditional Chinese Medicine

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Advances of mechanism research on treatment of experimental liver fibrosis with traditional Chinese medicine

Jie ZHANG, Lie-Ming XU   

  1. Institute of liver diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 200433,China
  • Received:2003-02-18 Online:2003-06-20 Published:2018-10-19

The paper reviewed and analyzed the literature in the past five years about the function of the cells and mediums in the liver, and the influence and mechanism of traditional Chinese drug therapy on experimental liver fibrosis. It reveals that the traditional Chinese drug therapy treats experimental liver fibrosis through lots of mechanisms. The author gives also some suggestions on the further research into liver fibrosis.

Key words: liver fibrosis, traditional Chinese drug therapy

CLC Number: 

  • R657.31
[1] Friedman SL . Hepatic fibrosis [A]. In: Schiff E, Maddrey W and Sorrell M. Disease of the liver[M]. 8th Ed. Philadelphia, PA: Raven press,1998.371-385.
[2] 王宝恩 . 肝星状细胞与肝纤维化[J]. 中华肝脏病杂志, 2000,8(4):197-199
doi: 10.3760/j.issn:1007-3418.2000.04.001
[3] 刘成海, 王晓玲, 刘平 . 丹酚酸A对肝星状细胞胶原代谢的作用[J]. 中西医结合肝病杂志, 1998,8(增刊·下):176
[4] 刘涛, 胡晋红, 蔡溱 , 等. 苦参碱抗肝纤维化机理的体外研究[J]. 解放军药学学报, 2000,16(3):119-122
doi: 10.3969/j.issn.1008-9926.2000.03.002
[5] 陈岳祥, 李石, 范列英 , 等. 丹参单体IH764-3抗肝纤维化作用的实验研究[J]. 中华医学杂志, 1998,78(8):636-637
doi: 10.3760/j:issn:0376-2491.1998.08.030
[6] 刘成海, 刘成, 刘平 , 等. 扶正化瘀方对肝星状细胞胶原生成的抑制作用[J]. 中华肝脏病杂志, 1998,6(1):5
[7] 陈文慧, 王海南, 刘成海 , 等. 福尔肝6号对肝星状细胞增殖的影响[J]. 云南中医学院学报, 2001,24(4):11-12,15
doi: 10.3969/j.issn.1000-2723.2001.04.005
[8] 杨文卓, 曾民德 . 肝纤维化的发生机制及病理生理[J]. 国外医学·消化系疾病分册, 2000,20(4):216-221
[9] 钟鸣, 余胜民, 黄琳芸 . 排钱草总生物碱对实验性肝纤维化动物相关指标的作用[J]. 肝脏, 2001,6(3):168-170
doi: 10.3969/j.issn.1008-1704.2001.03.009
[10] 展玉涛, 李定国, 魏红山 , 等. 大黄素对大鼠肝纤维化形成的影响[J]. 中国中西医结合杂志, 2000,20(4):276-278
doi: 10.7661/CJIM.2000.4.276
[11] 成扬, 张旻, 李华 , 等. 氧化苦参碱对小鼠免疫性肝纤维化作用机制的研究[J]. 现代实用医学, 2001,13(1):16-17
[12] 刘平, 季光, 洪嘉禾 , 等. 四氯化碳大鼠肝纤维化肝细胞生成白蛋白与胶原的变化及中药药物血清的影响[J]. 中华肝脏病杂志, 1998,6(1):44-45
doi: 10.3760/j.issn:1007-3418.1998.01.022
[13] 季光, 刘平, 胡义扬 , 等. 四氯化碳蒸熏法致肝细胞急性损伤时的功能变化及扶正化瘀方药物血清的调节作用[J]. 中西医结合肝病杂志, 1998,8(4):215-218
[14] 曹献英, 賁长恩, 于世瀛 , 等. 活血化瘀方药治疗大鼠肝纤维化的组织化学和血清学实验研究[J]. 北京中医药大学学报, 1998,21(2):35-37
[15] 曹献英, 賁长恩, 于世瀛 , 等. 活血化瘀方药抗大鼠肝纤维化的光镜及组织化学的实验观察[J]. 解剖科学进展, 1997,3(3):221
[16] 王津生, 杨大峥, 刘作恩 , 等. 抗纤丸对实验性肝纤维化的治疗作用[J]. 天津药学, 1997,9(1):20-21
[17] 刘成海, 熊磊, 刘平 , 等. MTT法观察三七总甙对NIH/3T3成纤维细胞毒性作用与增殖的影响[J]. 中国中西医结合脾胃杂志, 1999,7(4):203-205
[18] 刘平, 刘成, 刘成海 , 等. 扶正化瘀方药对NIH/3T3成纤维细胞增殖及胶原表达的影响[J]. 肝脏, 1998,3(4):21-24
[19] 甘乐文, 王国俊, 李玉莉 , 等. 氧化苦参碱对大鼠肝纤维化的影响[J]. 第二军医大学学报, 1999,20(7):445-448
doi: 10.3321/j.issn:0258-879X.1999.07.012
[20] 陈伟忠, 张俊平, 许青 , 等. 苦参碱对大鼠实验性肝纤维化的影响[J]. 第二军医大学学报, 1996,17(5):424-426
[21] 刘成海, 刘平, 胡义扬 , 等. 丹酚酸B盐刺激肝星状细胞活化与胞内信号转导的作用[A]. 2002年全国中西医结合肝病学术会议论文汇编[C]. 贵阳, 2002. 162-163.
[22] 王要军, 权启镇, 孙自勤 , 等. 黄芪对实验性肝纤维化组织ICAM-1表达影响的免疫组化研究[J]. 中国临床药理学与治疗学, 2000,5(1):49-51
doi: 10.3969/j.issn.1009-2501.2000.01.014
[23] 刘成海, 王晓玲, 刘平 , 等. 扶正化瘀319方药物血清对肝星状细胞Ⅰ型胶原及转化生长因子β1表达的影响[J]. 中国中西医结合杂志, 1999,19(7):412-414
doi: 10.7661/CJIM.1999.7.412
[24] 刘成, 胡义扬, 汪润平 , 等. 丹酚酸A抗过氧化鼠肝损伤的作用[J]. 世界华人消化杂志, 1999,7(7):570-572
doi: 10.3969/j.issn.1009-3079.1999.07.007
[25] 王红, 陈在忠 . 川芎嗪对大鼠肝纤维化脂质过氧化的影响[J]. 中华肝脏病杂志, 2000,8(2):98
doi: 10.3760/j.issn:1007-3418.2000.02.032
[26] 刘永刚, 陈厚昌, 蒋毅萍 , 等. 丹参酮ⅡA对四氯化碳致大鼠肝纤维化的实验研究[J]. 中药材, 2002,25(1):31-33
doi: 10.3321/j.issn:1001-4454.2002.01.014
[27] 廖力, 张愉快, 王可耕 , 等. 绞股兰总皂甙减轻小鼠血吸虫性肝纤维化的实验观察[J]. 衡阳医学院学报, 1998,26(2):139-141
[28] 张永刚, 迟彦邦, 杨彤翰 , 等. 粉防己碱对胆汁性肝纤维化保护作用的实验研究[J]. 中华肝胆外科杂志, 1999,5(5):317-320
[29] 杨文卓, 曾民德, 陆伦根 , 等. 氧化苦参碱预防半乳糖胺诱导的大鼠肝纤维化的实验研究[J]. 肝脏, 2002,7(1):2-4
doi: 10.3969/j.issn.1008-1704.2002.01.002
[30] 李玲, 李诚秀, 黄能慧 , 等. 汉丹肝乐对免疫性肝纤维化大鼠一氧化氮的影响[J]. 贵阳医学院学报, 2001,26(4):294-296
[31] 徐列明 . 如何适应中国的特点进一步开展肝纤维化研究[J]. 中西医结合肝病杂志, 2002,12(1):1-3
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