Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (2): 206-210.doi: 10.3736/jcim20060221

Special Issue: Traditional Chinese Medicine

• Literature Review • Previous Articles     Next Articles

Progress in experimental study on inhibitory effect of traditional Chinese medicine on liver fibrosis

Bin Zhang1, Lin-tai Wang2   

  1. 1. Department of Infectious Diseases,Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    2. Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China
  • Online:2006-03-20 Published:2006-03-15

Key words: Liver fibrosis, Drugs, Chinese herbal, Experimental study, Models, Animal, Cell model

CLC Number: 

  • R286.1
[1] Senties-Gomez MD, Galvez-Gastelum FJ, Meza-Garcia E , et al. Hepatic fibrosis: role of matrix metalloproteases and TGFbeta[J]. Gac Med Mex, 2005,141(4):315-322
pmid: 16164129
[2] Garciade Leon Mdel C, Montfort I, Tello Montes E , et al. Hepatocyte production of modulators of extracellular liver matrix in normal and cirrhotic rat liver[J]. Exp Mol Pathol, 2006,80(1):97-108
[3] Campbell JS, Hughes SD, Gilbertson DG , et al. Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma[J]. Proc Natl Acad Sci U S A, 2005,102(9):3389-3394
doi: 10.1073/pnas.0409722102 pmid: 15728360
[4] Lee TY, Wang GJ, Chiu JH , et al. Long-term administration of Salvia miltiorrhiza ameliorates carbon tetrachloride-induced hepatic fibrosis in rats[J]. J Pharm Pharmacol, 2003,55(11):1561-1568
[5] Bhimani EK, Serracino-Inglott F, Sarela AI , et al. Hepatic and mesenteric nitric oxide synthase expression in a rat model of CCl4-induced cirrhosis[J]. J Surg Res, 2003,113(1):172-178
[6] 李立华, 张国升, 戴敏 , 等. 芦根多糖对四氯化碳致肝纤维化大鼠的保肝作用[J]. 安徽中医学院学报, 2005,24(2):24-26
doi: 10.3969/j.issn.1000-2219.2005.02.013
[7] 张万国, 胡晋红, 黄瑾 . 桑黄治疗大鼠肝纤维化实验研究[J]. 中西医结合肝病杂志, 2002,12(6):348-350
[8] 陆伦根, 曾民德, 茅益民 , 等. 氧化苦参碱对四氯化碳诱导的大鼠肝纤维化Ⅰ、Ⅲ、Ⅳ型胶原表达的影响[J]. 世界华人消化杂志, 2003,11(10):1488-1491
doi: 10.3969/j.issn.1009-3079.2003.10.006
[9] 郑书国, 鄢顺琴, 凤良元 . 肝纤康防治肝纤维化的实验研究[J]. 安徽中医学院学报, 2002,21(5):37-39
[10] 杨舜民, 张良, 周玲玲 , 等. 紫七软肝对四氯化碳所致慢性肝纤维化大鼠的肝保护作用[J]. 南京中医药大学学报(自然科学版), 2002,18(6):345-346
doi: 10.3969/j.issn.1000-5005.2002.06.011
[11] 赵玉瑶, 刘方洲, 杨小平 , 等. 臌胀片抗大鼠肝纤维化作用的实验研究[J]. 中国中西医结合杂志, 2003,23(12):922-925
doi: 10.7661/CJIM.2003.12.922
[12] 刘玉侃, 沈薇 . 虫草菌丝对大鼠实验性肝纤维化肝细胞增生的影响[J]. 世界华人消化杂志, 2002,10(4):388-391
[13] 周小舟, 周大桥, 漆艳平 , 等. 软肝冲剂对四氯化碳肝硬化大鼠P21 mRNA表达的影响[J]. 湖南中医学院学报, 2002,22(4):13-15
doi: 10.3969/j.issn.1674-070X.2002.04.005
[14] 赵稳兴, 陈忠明, 候辉 , 等. 木犀草素降低CCl4诱导的大鼠肝纤维化[J]. 世界华人消化杂志, 2002,10(7):779-782
doi: 10.3969/j.issn.1009-3079.2002.07.008
[15] 朱冰, 刘殿武, 房文亮 , 等. 抗纤Ⅰ号对实验性肝纤维化大鼠组织Ⅰ、Ⅲ型胶原及转移生长因子β1 mRNA表达的影响[J]. 中国中医基础医学杂志, 2003,9(1):21-23
doi: 10.3969/j.issn.1006-3250.2003.01.009
[16] 陈洪, 陆亚琴, 刘顺英 , 等. 地龙2号对大鼠肝纤维化TGF-β1, MMP-13及TIMP-1 mRNA和蛋白表达的影响[J]. 世界华人消化杂志, 2004,12(10):2333-2337
[17] Gotardo BM, Andrade RG, Oliveira LF , et al. Production of septal fibrosis of the liver by means of foreign protein injections into rats[J]. Rev Soc Bras Med Trop, 2003,36(5):577-580
doi: 10.1590/S0037-86822003000500006 pmid: 14576871
[18] 孙守才, 李晓苗, 曾福海 , 等. 加味四逆散防治大鼠免疫性肝纤维化的实验研究[J]. 陕西中医学院学报, 2002,25(2):43-46
[19] 张国梁, 戴敏, 许钒 , 等. 软肝饮对免疫性肝纤维化大鼠胶原代谢水平的影响[J]. 安徽中医学院学报, 2005,24(1):17-19
[20] 姜学连, 靳艳华, 贲长恩 . 中药2号抗大鼠肝纤维化的组织化学及免疫组织化学实验研究[J]. 中国中医基础医学杂志, 2002,8(11):48-50
doi: 10.3969/j.issn.1006-3250.2002.11.017
[21] 段志军, 李吉彦, 丛振日 , 等. 益气软肝法对肝纤维化大鼠肝组织MMP-1/TIMP-1活性的影响[J]. 中国中医基础医学杂志, 2002,8(9):32-34
doi: 10.3969/j.issn.1006-3250.2002.09.013
[22] 晏军, 赵晶, 章文莉 . 软肝化癥丸抗肝纤维化的实验研究[J]. 中国医药学报, 2002,17(5):313-314
doi: 10.3969/j.issn.1673-1727.2002.05.023
[23] 康文臻, 谢玉梅, 聂青和 , 等. 苦参素对实验性大鼠肝纤维化防治作用的研究[J]. 世界华人消化杂志, 2003,11(2):195-198
doi: 10.3969/j.issn.1009-3079.2003.02.016
[24] 谢玉梅, 聂青和, 周永兴 , 等. 中药双甲五灵冲剂对免疫性肝纤维化大鼠肝组织中TIMPs蛋白及基因表达的影响[J]. 世界华人消化杂志, 2003,11(2):199-203
doi: 10.3969/j.issn.1009-3079.2003.02.017
[25] Shimamoto T, Mori Y, Takagi H , et al. Experimental studies on morphological changes of microcirculation of DMN-induced liver cirrhosis after normothermic ischemia with charge-coupled device microscope[J]. J Gastroenterol Hepatol, 2003,18(9):1071-1075
[26] Jin YL, Enzan H, Kuroda N , et al. Tissue remodeling following submassive hemorrhagic necrosis in rat livers induced by an intraperitoneal injection of dimethylnitrosamine[J]. Virchows Arch, 2003,442(1):39-47
[27] 陆雄, 刘平, 刘成海 , 等. 扶正化瘀方促进二甲基亚硝胺肝纤维化大鼠肝窦毛细血管化逆转作用的实验研究[J]. 中医杂志, 2003,44(2):136-139
doi: 10.3321/j.issn:1001-1668.2003.02.036
[28] 谭春雨, 谭善忠, 蒋健 , 等. 扶正化瘀方对DMN肝纤维化模型鼠肝细胞凋亡的影响[J]. 上海中医药杂志, 2005,39(1):47-49
doi: 10.3969/j.issn.1007-1334.2005.01.022
[29] Kato J, Sato Y, Inui N , et al. Ethanol induces transforming growth factor-alpha expression in hepatocytes, leading to stimulation of collagen synjournal by hepatic stellate cells[J]. Alcohol Clin Exp Res, 2003,27(8 Suppl):58S-63S
[30] 丁霞, 蒙一纯, 贲长恩 , 等. 酒精性肝纤维化动物模型的建立[J]. 中国中医基础医学杂志, 1999,5(7):47-48
doi: 10.3969/j.issn.1006-3250.1999.07.019
[31] 张晓平, 陈建明, 强世平 , 等. 山桃仁水煎提取物对肝纤维化小鼠血清Ⅰ、Ⅲ型前胶原的降解作用[J]. 福建中医药, 2002,33(4):36-37
doi: 10.3969/j.issn.1000-338X.2002.04.033
[32] 阴赪宏, 马雪梅, 马红 , 等. 复方861含药血清对HSC-T6细胞Ⅰ型胶原、基质金属蛋白酶组织抑制因子1 mRNA表达的影响[J]. 中西医结合肝病杂志, 2002,12(5):286-289
doi: 10.3969/j.issn.1005-0264.2002.05.012
[33] 郭顺根, 张玮, 江涛 , 等. 活血化瘀方药理血清对离体肝星形细胞影响的研究[J]. 北京中医药大学学报, 2003,26(1):24-26
doi: 10.3321/j.issn:1006-2157.2003.01.010
[34] 张珉, 张俊平, 王杰松 , 等. 黄颜木素对HSC-T6细胞增殖和胶原合成的影响[J]. 第二军医大学学报, 1999,20(5):304-305
doi: 10.3321/j.issn:0258-879X.1999.05.011
[35] 包云, 张斌, 王灵台 . 抗纤复方对纤维肝大鼠肝细胞基底膜基质生成的影响[J]. 现代中西医结合杂志, 2001,10(17):1620-1622
doi: 10.3969/j.issn.1008-8849.2001.17.007
[36] 宋健, 张兴荣, 朱樑 , 等. 苦参素对成纤维细胞增殖及Ⅲ型原胶原mRNA表达的影响[J]. 第二军医大学学报, 1999,20(6):356-358
doi: 10.3321/j.issn:0258-879X.1999.06.005
[37] 姜春萌, 刘成, 刘成海 , 等. 扶正化瘀方对大鼠CCl4损伤肝Kupffer细胞功能的影响[J]. 中西医结合肝病杂志, 2000,10(5):26-28
[38] 郭传勇, 申振宇, 钟敏章 , 等. 中药清肝饮对大鼠肝贮脂细胞和成纤维细胞增殖效应的调控作用[J]. 中国中医药科技, 2000,7(5):285-286
[39] 王要军, 权启镇, 孙自勤 , 等. 复方汉防己对人成纤维化细胞增殖和凋亡及层粘蛋白合成的影响[J]. 德国医学, 2000,17(1):27-29
[1] Deng-hai Zhang, Kun-lun Wu, Xue Zhang, Sheng-qiong Deng, Bin Peng. In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus. Journal of Integrative Medicine, 2020, 18(2): 152-158.
[2] Lena Grönblom Lundström, Ulrika Aasa, Yan Zhang, Tobias Sundberg. Health care in light of different theories of health—A proposed framework for integrating a social humanistic perspective into health care. Journal of Integrative Medicine, 2019, 17(5): 321-327.
[3] Stefania Lamponi, Anna Maria Aloisi, Claudia Bonechi, Marco Consumi, Alessandro Donati, Gemma Leone, Claudio Rossi, Gabriella Tamasi, Luana Ghiandai, Ersilia Ferrini, Paolo Fiorenzani, Ilaria Ceccarelli, Agnese Magnani. Evaluation of in vitro cell and blood compatibility and in vivo analgesic activity of plant-derived dietary supplements. Journal of Integrative Medicine, 2019, 17(3): 213-220.
[4] Carola Analía Torres, Cristina Marisel Pérez Zamora, María Beatriz Nuñez, Ana María Gonzalez. In vitro antioxidant, antilipoxygenase and antimicrobial activities of extracts from seven climbing plants belonging to the Bignoniaceae. Journal of Integrative Medicine, 2018, 16(4): 255-262.
[5] Shui-jie Shen, Yong-hong Zhang, Xiao-xia Gu, Shui-ju Jiang, Ling-jun Xu. Yangfei Kongliu Formula, a compound Chinese herbal medicine, combined with cisplatin, inhibits growth of lung cancer cells through transforming growth factor-β1 signaling pathway. Journal of Integrative Medicine, 2017, 15(3): 242-251.
[6] Liliana Zazueta-Beltrán, Lorena Medina-Aymerich, Nadia Estela Díaz-Triste, Aracely Evangelina Chávez-Piña, Gilberto Castañeda-Hernández, Leticia Cruz-Antonio. Evidence against the participation of a pharmacokinetic interaction in the protective effect of single-dose curcumin against gastrointestinal damage induced by indomethacin in rats. Journal of Integrative Medicine, 2017, 15(2): 151-157.
[7] Tom Fleischer, Tung-Ti Chang, Hung-Rong Yen. Post-hematopoietic stem cell transplantation in patients with hematologic disorders: Chinese herbal medicine for an unmet need. Journal of Integrative Medicine, 2016, 14(5): 322-335.
[8] JiaXia, Li-qunHe, XiaoSu. Interventional mechanisms of herbs or herbal extracts on renal interstitial fibrosis. Journal of Integrative Medicine, 2016, 14(3): 165-173.
[9] Mojtaba Heydari, Mohammad Hashem Hashempur, Mohammad Hosein Ayati, Detlev Quintern, Majid Nimrouzi, Seyed Hamdollah Mosavat. The use of Chinese herbal drugs in Islamic medicine. Journal of Integrative Medicine, 2015, 13(6): 363-367.
[10] Wei Chiang Chan Eric, Kuin Wong Siu. Phytochemistry and pharmacology of ornamental gingers, Hedychium coronarium and Alpinia purpurata: A review. Journal of Integrative Medicine, 2015, 13(6): 368-379.
[11] Arthur Yin Fan, Sarah Faggert . Dr. Gene Bruno: The beginning of the acupuncture profession in the United States (1969-1979) — Acupuncture, medical acupuncture and animal acupuncture. Journal of Integrative Medicine, 2015, 13(5): 281-288.
[12] Xiao-ping Huang, Huang Ding, Jin-dong Lu, Ying-hong Tang, Bing-xiang Deng, Chang-qing Deng . Autophagy in cerebral ischemia and the effects of traditional Chinese medicine. Journal of Integrative Medicine, 2015, 13(5): 289-296.
[13] Swapnil P. Borse, Bhagyashree B. Kamble. Effects of Ayurvedic Rasayana botanicals on CYP3A4 isoenzyme system. Journal of Integrative Medicine, 2015, 13(3): 165-172.
[14] Vamsi Reddy, Arvind Sridhar, Roberto F. Machado, Jiwang Chen. High sodium causes hypertension: Evidence from clinical trials and animal experiments. Journal of Integrative Medicine, 2015, 13(1): 1-8.
[15] Elizabeth Abidemi Balogun, Sylvia Orume Malomo, Joseph Oluwatope Adebayo, Ahmed Adebayo Ishola, Ayodele Olufemi Soladoye, Lawrence Aderemi Olatunji, Olatunji Matthew Kolawole, Stephen Olubunmi Oguntoye, Abiola Samuel Babatunde, Oluwole Busayo Akinola . In vivo antimalarial activity and toxicological effects of methanolic extract of Cocos nucifera (Dwarf red variety) husk fibre. Journal of Integrative Medicine, 2014, 12(6): 504-511.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Wei Zhang, Xiang-feng Lu, Xiao-mei Zhang, Jian-jun Wu, Liang-duo Jiang. A rat model of pulmonary fibrosis induced by infusing bleomycin quickly through tracheal intubation. Journal of Chinese Integrative Medicine, 2008, 6(1): 60-67
[2] Ming-qing Wei , Jin-zhou Tian , Jing Shi , Fu-yun Ma , Ying-chun Miao , Yong-yan Wang. Effects of Chinese medicine for promoting blood circulation and removing blood stasis in treating patients with mild to moderate vascular dementia: a randomized, double-blind and parallel-controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(11): 1240-1246
[3] Nian-hong Wang , Jun-tao Yan , Wu-quan Sun , Yong-shan Hu , Jun Xia , Li-cheng Wei , Jie Jia , Gui-lin Ouyang , Yong He , Yan-ming Guo , Jie Xu . Effects of early application of Tuina treatment on quadriceps surface myoelectricity in patients after total knee arthroplasty: a randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(11): 1247-1253
[4] Jalal Zaringhalam, Akhtar Akbari, Elaheh Tekieh, Homa Manaheji, Shamsali Rezazadeh. Achillea santolina reduces serum interlukin-6 level and hyperalgesia during complete Freund9 s adjuvant-induced inflammation in male Wistar rats. Journal of Chinese Integrative Medicine, 2010, 8(12): 1180-1189
[5] Mei-jun Lü, Hui-yong Zhang, Zhe Zhang, Guan-lin Yang. Measurement of health-related quality of life in coronary heart disease: A review. Journal of Chinese Integrative Medicine, 2011, 9(12): 1277-1285
[6] Shuo Zhang , Hong-cai Shang. Correlation between traditional Chinese medicine syndromes and omics: A literature review. Journal of Chinese Integrative Medicine, 2011, 9(12): 1286-1291
[7] Qin-hui Fu, Jian Pei, Jian-rong Hui, Yi Song . Studies on dynamic changes in traditional Chinese medicine syndrome patterns for stroke using data-driven and model-driven approaches: A review. Journal of Chinese Integrative Medicine, 2011, 9(12): 1292-1300
[8] Jia Guo, Li-na Wang, Dong Li. Exploring the effects of Chinese medicine in improving uterine endometrial blood flow for increasing the successful rate of in vitro fertilization and embryo transfer. Journal of Chinese Integrative Medicine, 2011, 9(12): 1301-1306
[9] Liang-ping Hu, Xiao-lei Bao, Xue Guan, Shi-guo Zhou. Estimation of sample size and testing power (Part 3). Journal of Chinese Integrative Medicine, 2011, 9(12): 1307-1311
[10] Jian-sheng Li, Su-yun Li, Xue-qing Yu, Yang Xie. Bufei Yishen Granule combined with acupoint-sticking therapy in patients with stable chronic obstructive pulmonary disease: Study protocol of a multicenter, randomized, double-blind, active-controlled trial. Journal of Chinese Integrative Medicine, 2011, 9(12): 1312-1318