240例病毒性心肌炎室性早搏日分布的中医病理节律研究

doi:10.3736/jcim20050505

Abstract

Objective

To explore the circadian distribution of premature ventricular contractions (PVCs) in patients with viral myocarditis (VM) according to the theory of chronomedicine in traditional Chinese medicine (TCM) in order to find out the scientific evidence for a reasonable administration time.

Methods

Two hundred and forty patients with VM were enrolled and electrocardiograms were examined for all by Holter monitor. The circadian distribution of PVCs was evaluated according to the theory of chronomedicine of TCM about time periods corresponding to five zang viscera.

Results

PVCs mostly happened in periods of 3∶00-5∶00, 5∶00-7∶00, 7∶00-9∶00 and 9∶00-11∶00, in which 5∶00-7∶00 was the most serious time. Less PVCs happened in periods of 17∶00-19∶00, 19∶00-21∶00 and 21∶00-23∶00. The frequency of PVCs in midnight also increased with aging. The time periods of the frequency peak of PVCs in patients with different syndromes were also different. In patients with syndrome of pathogenic heat invading heart (PHIH), the PVCs mostly appeared in midday. In patients with syndrome of flaring of fire due to yin-deficiency (FFYD), the PVCs were most serious in daytime and aggravated at noon. And in patients with syndrome of insufficiency of heart-qi and yang (IHQY), the PVCs mostly happened in early morning or midnight.

Conclusion

There was a manifest regulation of the pathological circadian rhythm of PVCs in patients with VM. The circadian distributions of PVCs were variable in patients with different syndromes. Therefore the theory of chronomedicine of TCM may be used to guide the treatment based on syndrome differentiation.

Key words: Circadian rhythm, Myocarditis, Ventricular premature complexs

CLC Number:

R226.4

Song Cui, Xin-lin Chen, Mei-xian Jiang. Study on pathological rhythm of traditional Chinese medicine about circadian distribution of premature ventricular contractions in 240 patients with viral myocarditis. Journal of Chinese Integrative Medicine, 2005, 3(5): 355-358.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20050505

http://www.jcimjournal.com/EN/Y2005/V3/I5/355

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References 6

[1]	马文珠, 张寄南 .心肌疾病( 第1版)[M]. 南京: 江苏科学技术出版社, 2000,( 第1版):188-189
[2]	吴梓梁 . 实用临床儿科学(第1版)[M]. 广州: 广州出版社, 1998,( 第1版):1105-1106
[3]	Raeder EA, Hohnloser SH, Graboys TB , et al. Spontaneous variability and circadian distribution of ectopic activity in patients with malignant ventricular arrhythmia[J]. Am Coll Cardiol, 1998,12(3):656-661
[4]	李佩璋, 周青, 朱毓仁 , 等. 人体心率、心律、心肌缺血与季日、时辰的关系[J]. 心电学杂志, 1992,11(3):138-141
[5]	Rocco MB, Barry J, Campbell S , et al. Circadian variation of transient myocardial ischemia in patients with coronary artery disease[J]. Circulation, 1987,75(2):395-400 doi: 10.1161/01.CIR.75.2.395 pmid: 3802443
[6]	Quyyumi AA, Mockus L, Wright C , et al. Morphology of ambulatory ST segment changes in patients with varying severity of coronary artery disease. Investigation of the frequency of nocturnal ischaemia and coronary spasm[J]. Br Heart J, 1985,53(2):186-193 doi: 10.1136/hrt.53.2.186

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Group		n	Circadian distribution of peak frequency in different time periods
Group		n	23∶00-1∶00	1∶00-3∶00	3∶00-5∶00			5∶00-7∶00	7∶00-9∶00		9∶00-11∶00
<30 years		53	2 (3.77)	2 (3.77)	12(22.64)			10 (18.87)	9 (16.98)		8 (15.09)
30-39 years		80	9 (11.25)	9 (11.25)	8 (10.00)			15 (18.75)	5 (6.25)		12 (15.00)
40-50 years		107	10 (9.35)	15 (14.02*)	11 (10.28)			23(21.50)	13 (12.15)		13 (12.15)
Total		240	21 (8.75)	26 (10.83)	31 (12.92)			48 (20.00)	27 (11.25)		33 (13.75)
Group	n		Circadian distribution of peak frequency in different time periods
Group	n		11∶00-13∶00	13∶00-15∶00		15∶00-17∶00	17∶00-19∶00			19∶00-21∶00		21∶00-23∶00
<30 years	53		4 (7.54)	3 (5.66)		1 (1.89)	1 (1.89)			1 (1.89)		0 (0)
30-39 years	80		8 (10.00)	5 (6.25)		4 (5.00)	1 (1.25)			2 (2.50)		2 (2.50)
40-50 years	107		9 (8.41)	4 (3.74)		2 (1.87)	2 (1.87)			2 (1.87)		3 (2.80)
Total	240		21 (8.75)	12 (5.00)		7 (2.92)	4 (1.67)			5 (2.08)		5 (2.08)

Group	n	Circadian distribution of peak frequency in different time periods (corresponding zang viscera)
Group	n	3∶00-9∶00 (liver)	9∶00-15∶00 (heart)	13∶00-17∶00 (spleen)	15∶00-23∶00 (lung)	21∶00-3∶00 (kidney)
<30 years	53	31 (54.39*)	15 (26.32)	4 (7.02)	3 (5.26)	4 (7.02)
30-39 years	80	28 (31.46)	25 (28.09)	9 (10.11)	7 (7.87)	20 (22.47)
40-50 years	107	47 (41.59*)	26 (23.01)	6 (5.31)	6 (5.31)	28 (24.78)
Total	240	106 (40.93)	66 (25.48)	19 (7.34)	16 (6.18)	52 (20.08)

Group	n	Circadian distribution of peak frequency in different time periods (corresponding zang viscera)
Group	n	3∶00-9∶00 (liver)	9∶00-15∶00 (heart)	13∶00-17∶00 (spleen)	15∶00-23∶00 (lung)	21∶00-3∶00 (kidney)
PHIP	20	4 (18.18)	13 (59.09*)	2 (9.09)	2 (9.09)	1 (4.55)
FFYD	20	1 (4.00)	11 (44.00*)	5 (20.00)	5 (20.00)	3 (12.00)
IHQY	20	8 (38.10△)	2 (9.52)	1 (4.76)	2 (9.52)	8 (38.10^△)

Study on pathological rhythm of traditional Chinese medicine about circadian distribution of premature ventricular contractions in 240 patients with viral myocarditis

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