SUBSCRIBE
Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (5): 467-472.doi: 10.3736/jcim20060505

• Review • Previous Articles     Next Articles

Curative effects of Fuzheng Huayu Capsules on hepatic fibrosis and the functional mechanisms: A review

Chang-qing Zhao1,2,Yi-qing Wu1,Lie-ming Xu1,2   

  1. 1. Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2. Department of Liver Cirrhosis, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Online:2006-09-30 Published:2006-09-15

RichHTML

3

PDF (PC)

111

Like

Deficiency of Qi (healthy energy) and blood stasis are the basic pathological changes of hepatic fibrosis according to the theories of traditional Chinese medicine. Fuzheng Huayu Capsule, a compound Chinese herbal medicine for hepatic fibrosis, is produced in the light of this pathological mechanism. More than a decade of clinical studies and experimental researches show that this medicine has effects of protecting hepatic cells, relieving liver injury, and controlling the development of hepatic fibrosis. It has definite functional mechanisms on anti-hepatic fibrosis. It is a safe and effective medicine for hepatic fibrosis, and deserves to be well introduced to clinic.

Key words: Fuzheng Huayu Capsules, Hepatic fibrosis, Clinical studies, Functional mechanisms

CLC Number: 

  • R285.6
[1] 刘平, 胡义扬, 刘成 , 等. 扶正化瘀胶囊干预慢性乙型肝炎肝纤维化作用的多中心临床研究[J]. 中西医结合学报, 2003,1(2):89-98, 102
doi: 10.3969/j.issn.1008-861X.2002.01.013
[2] 温伟波, 王华宁, 李莉 .肝平胶囊( 复方319胶囊)治疗慢性乙型肝炎肝纤维化临床疗效观察[J]. 中国民族民间医药杂志, 2002,11(4):210-212
doi: 10.3969/j.issn.1007-8517.2002.04.013
[3] 吕萍, 杨金龙, 刘成 , 等. 复方319胶囊治疗慢性乙型肝炎51例[J]. 中西医结合肝病杂志, 1996,6(1):32-33
[4] 王晖, 周霞秋, 蔡伊梅 . 扶正化瘀胶囊治疗慢性乙型肝炎疗效观察[J]. 中国医药导刊, 2003,5(1):66-67
doi: 10.3969/j.issn.1009-0959.2003.01.027
[5] 丁曙光, 汪习成, 胡丽佳 , 等. 扶正化瘀胶囊治疗慢性乙型肝炎肝纤维化的临床观察[J]. 中国校医, 2003,17(2):173-174
doi: 10.3969/j.issn.1001-7062.2003.02.051
[6] 刘平, 刘成, 陈高潮 , 等. 扶正化瘀319方治疗慢性乙型肝炎及其对纤维化血清学指标的影响[J]. 中国中西医结合杂志, 1996,16(10):588-592
doi: 10.7661/CJIM.1996.10.588
[7] 吕萍, 杨金龙, 刘成 , 等. 复方319胶囊治疗慢性乙型肝炎51例[J]. 中西医结合肝病杂志, 1996,6(6):32-33
[8] 刘成, 刘平, 胡义扬 , 等. 扶正化瘀方抗肝纤维化的研究[J]. 中医杂志, 1994,35(10):602-604
[9] 佘为民, 胡德昌, 周朝晖 , 等. 肝平胶囊治疗慢性乙型肝炎患者肝纤维化的临床研究[J]. 肝脏, 2002,7(4):254-255
doi: 10.3969/j.issn.1008-1704.2002.04.014
[10] 徐列明, 刘平, 刘成 , 等. 扶正化瘀319方治疗慢性乙型肝炎肝纤维化[J]. 中华肝脏病杂志, 1997,5(4):207-209
[11] 朱剑亮, 黄耀义, 刘平 , 等. 319肝平胶囊对肝炎后肝硬化异常免疫功能的调整[J]. 中国中医药科技, 1994,1(2):23-25
[12] 刘成, 刘平, 胡义扬 , 等. 扶正化瘀方治疗肝炎后肝硬化的临床观察[J]. 中国中西医结合杂志, 1996,16(8):459-462
doi: 10.7661/CJIM.1996.8.459
[13] 黄运坤, 赵长青, 胡义扬 , 等. 扶正化瘀胶囊对慢性肝病患者血清氨基酸谱异常的调整作用[J]. 中华肝脏病杂志, 2005,13(3):230-231
doi: 10.3760/j.issn:1007-3418.2005.03.024
[14] 胡义扬, 刘成, 刘平 , 等. 扶正化瘀方对肝硬化患者内分泌激素紊乱的调节作用[J]. 中国医药学报, 1992,7(5):27-29
[15] 季青 . 扶正化瘀胶囊治疗34例慢性肝炎肝纤维化的疗效观察 . 全国中西医结合肝病学术会议,北京 2004.
[16] 刘平, 刘乃明, 徐列明 , 等. 丹参酸乙对四氯化碳体外损伤原代培养大鼠肝细胞的直接保护作用[J]. 中国中药杂志, 1997,22(5):303-305
doi: 10.1007/BF02951625
[17] >谭春雨 . 扶正化瘀方影响肝纤维化大鼠肝脏细胞凋亡的研究 .上海:上海中医药大学肝病研究所, 2003.
[18] 季光, 刘平, 洪嘉禾 , 等. 扶正化瘀方药物血清对原代培养纤维肝细胞胶原生成及分泌白蛋白功能的影响[J]. 中西医结合肝病杂志, 1997,7(1):25-28
[19] Niemela O, Parkkila S , Yla-herttuala, et al. Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease[J]. Hepatology, 1995,22(4):1208-1214
[20] 胡义扬, 刘平, 刘成 , 等. CCl4急性肝损伤肝SOD, MDA的动态变化及扶正化瘀方对其影响[J]. 中西医结合肝病杂志, 1997,7(2):87-89, 92
[21] 胡义扬, 刘成, 刘平 , 等. 扶正化瘀方抗CCl4大鼠肝纤维化作用与抗脂质过氧化[J]. 新消化病学杂志, 1997,5(8):485-486
[22] 刘平, 胡义扬, 刘成海 , 等. 扶正化瘀方抗二甲基亚硝胺大鼠肝纤维化作用及其对贮脂细胞的影响[J]. 中国中医药科技, 1997,4(2):99-101
[23] 刘成海, 刘成, 刘平 , 等. 扶正化瘀方对大鼠肝贮脂细胞增殖的影响[J]. 中西医结合肝病杂志, 1996,6(2):19-20, 31
[24] 刘平, 刘成海, 刘成 , 等. 扶正化瘀方抑制大鼠肝贮脂细胞增殖及胶原生成的血清药理学研究[J]. 肝脏, 1996,1(3):152-156
[25] 谭春雨, 谭善忠, 蒋健 , 等. 扶正化瘀方对肝纤维化大鼠肝脏明胶酶、TIMP-2和星状细胞凋亡的影响[J]. 上海中医药大学学报, 2003,17(4):40-44
[26] 刘成海, 王晓玲, 刘平 , 等. 扶正化瘀319方药物血清对肝星状细胞I型胶原及转化生长因子β1表达的影响[J]. 中国中西医结合杂志, 1999,19(7):412-414
doi: 10.7661/CJIM.1999.7.412
[27] 姜春萌, 刘成, 刘成海 , 等. 扶正化瘀方对大鼠CCl4损伤肝Kupffer细胞功能的影响[J]. 中西医结合肝病杂志, 2000,10(5):26-28
[28] 刘成, 姜春萌, 刘平 . 扶正化瘀方对大鼠肝星状细胞旁分泌活化途径的抑制作用[J]. 中华消化杂志, 2001,21(6):367-369
[29] 刘成, 姜春萌, 刘成海 , 等. 扶正化瘀方对肝星状细胞分泌血管内皮生长因子的干预[J]. 中华肝脏病杂志, 2001,9(5):282-284
doi: 10.3760/j.issn:1007-3418.2001.05.010
[30] Chojkier M, Lyche KD, Filip M . Increased production of collagen in vivo by hepatocytes and nonparenchymal cells in rats with carbon tetrachloride-induced hepatic fibrosis[J]. Hepatology, 1988,8(4):808-814
[31] 刘成, 刘平, 刘成海 , 等. 扶正化瘀方对大鼠肝星状细胞、肝细胞、成纤维细胞胶原合成的影响[J]. 中国中西医结合脾胃杂志, 1998,6(1):29-31
[32] 刘成海, 刘成, 刘平 , 等. 扶正化瘀方对肝星状细胞胶原生成的抑制作用[J]. 中华肝脏病杂志, 1998,6(1):4
doi: 10.3760/j.issn:1007-3418.1998.01.020
[33] 季光, 刘平, 刘成 , 等. 扶正化瘀方药物血清对原代培养大鼠肝细胞增殖及胶原生成率的影响[J]. 中国实验方剂学杂志, 1997,3(3):20-23
[34] 刘平, 刘成, 刘成海 , 等. 扶正化瘀方对NIH/3T3成纤维细胞增殖及胶原表达的影响[J]. 肝脏, 1998,3(4):21-24
[35] 朱秀琴, 刘成, 刘平 , 等. 扶正化瘀方对大鼠皮肤成纤维细胞增殖和胶原生成的抑制作用[J]. 肝脏, 1998,3(1):31-34
[36] 刘平, 胡义扬, 徐列明 , 等. 扶正化瘀319方抗大鼠肝纤维化的研究[J]. 中国实验方剂学杂志, 1997,3(4):20-24
[1] Hepatology Committee of Chinese Association of Integrative Medicine, China. Guidelines for diagnosis and treatment of hepatic fibrosis with integrated traditional Chinese and Western medicine (2019 edition). Journal of Integrative Medicine, 2020, 18(3): 203-213.
[2] Deng-hao Liu, Zheng Wang, Zhang-yan Qin. Clinical effects of Shugan Jianpi Recipe on postadolescent acne in women. Journal of Chinese Integrative Medicine, 2009, 7(7): 671-673.
[3] Bin Zhang, Ling-tai Wang. Bushen Rougan Recipe in prevention of hepatic fibrosis in rats induced by dimethylnitrosamine: a study on its preliminary mechanism. Journal of Chinese Integrative Medicine, 2008, 6(9): 934-938.
[4] Yan-hui Sun, Yong-qing Cao, Jin-gen Lu, Hong-xiang Huang, Xiu-tian Guo. Internal opening incision with harmonic scalpel, remaining and tunnel thread-dragging methods in surgical management of posterior horseshoe fistula. Journal of Chinese Integrative Medicine, 2007, 5(5): 589-591.
[5] Li-xin Xiao, Jin-gen Lu. Clinical observation of suspended ligation and Milligan-Morgan hemorrhoidectomy in surgical management of circumferential mixed hemorrhoids. Journal of Chinese Integrative Medicine, 2007, 5(4): 460-462.
[6] Hong-yan Zhang, Qing Xia. Clinical study on severe acute pancreatitis complicated by hepatic insufficiency. Journal of Chinese Integrative Medicine, 2006, 4(1): 17-19.
[7] Ping Xue, Zong-wen Huang, Yong-hong Li, Jia Guo, Zhong-chao Wang, Jian-lei Zhao, Zhen You. Clinical study on severe acute pancreatitis associated with hypoalbuminemia in early stage. Journal of Chinese Integrative Medicine, 2005, 3(6): 443-445.
[8] Jian-yang Xu, Li-wu Liang, De-wen Qiu, Xiao Han. Method for studying traditional Chinese compound prescription. Journal of Chinese Integrative Medicine, 2005, 3(5): 347-350.
[9] Ping Xue, Zong-wen Huang, Jia Guo, Jian-lei Zhao, Yong-hong Li, Zhong-chao Wang. Clinical study of Chaiqin Chengqi Decoction in treating severe acute biliary pancreatitis. Journal of Chinese Integrative Medicine, 2005, 3(4): 263-264.
[10] Jun-ping Zhang, Yun Wang, Pei-yong Zheng. Pondering the problems of clinical effect assessment of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2005, 3(3): 181-183.
[11] Bin Zhang, Mo-bin Wan, Ling-tai Wang. Therapeutic effect of Bushen Rougan Recipe on hepatic fibrosis in rats. Journal of Chinese Integrative Medicine, 2005, 3(2): 132-135.
[12] Ke-ji Chen. Evaluation of clinical therapeutic effect for traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2005, 3(1): 1-2.
[13] Xiao-yi Zhang, Cheng-bao Kuang. Clinical observation on treatment of nonalcoholic fatty liver disease complicating hyperuricemia by Zhifang Ⅰ Decoction. Journal of Chinese Integrative Medicine, 2004, 2(4): 265-267.
[14] Bin Zhang, Mo-bin Wan, Lin-tai Wang. Expression of TIMP-1 and TGF-β1 mRNA in hepatic fibrosis rats and the therapeutic effects of Bushen Rougan Recipe. Journal of Chinese Integrative Medicine, 2004, 2(4): 274-277.
[15] Jun-mei Wu, Dong-yan Wei, Yong-fen Luo, Xiao-yong Xiang. Clinic reaseach on heroin de-addiction effects of acupuncture and its potentiality of preventing relapse. Journal of Chinese Integrative Medicine, 2003, 1(4): 268-272.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228
Journal of Integrative Medicine, ISSN: 2095-4964 CN 31-2083/R
Copyright © Journal of Integrative Medicine
Powered by Beijing Magtech Co. Ltd
沪公网安备31010602003416号      沪ICP备18017633号-3