Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (6): 443-445.doi: 10.3736/jcim20050606

• Original Clinical Research • Previous Articles     Next Articles

Clinical study on severe acute pancreatitis associated with hypoalbuminemia in early stage

Ping Xue, Zong-wen Huang, Yong-hong Li, Jia Guo, Zhong-chao Wang, Jian-lei Zhao, Zhen You   

  1. Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China
  • Received:2005-06-05 Online:2005-11-20 Published:2005-11-20
  • Contact: Zong-wen Huang


To investigate the occurring mechanism and clinical characteristics of severe acute pancreatitis (SAP) associated with hypoalbuminemia in early stage and its influence on prognosis of SAP and the preventive and therapeutic management of this disease.


One hundred and thirty-eight cases diagnosed as SAP complicated by hypoalbuminemia in early stage were accepted in our hospital from August 1, 2003 to December 31, 2004, and they were divided into 2 groups according to the level of plasma albumin: mild hypoalbuminemia (30 to 35 g/L) group and severe hypoalbuminemia (<30 g/L) group. The complications in the early stage, related parameters, and the incidence rate of infection and mortality in the later stage were evaluated respectively.


The incidence rates of renal dysfunction, shock, cardiovascular failure and gastrointestinal hemorrhage, the score of acute physiology and chronic health evaluation Ⅱ (APACHEⅡ) and the frequencies of pulse and breath in the severe hypoalbuminemia group were all higher than those in the mild hypoalbuminemia group (P<0.05 or P<0.01). The differences of incidence rate of hepatic failure and the scores of Ranson and Balthazar CT between these two groups had no statistical significance (P>0.05). The incidence rate of infection and the mortality in the severe hypoalbuminemia group were higher than those in the mild hypoalbuminemia group (P<0.01) in the later stage of SAP.


Hypoalbuminemia in the early stage can accelerate the deterioration in pathophysiology of SAP. The lower level of the plasma albumin is in the early stage, the more complications and the higher incidence rate of infection and mortality will be in the later stage. To relieve the extent of systemic inflammatory response syndrome (SIRS) and abundant supplement of albumin, amino acid and lipid in time may be crucial to prevent the occurrence and deterioration of hypoalbuminemia.

Key words: Pancreatitis, Acute necrotizing, Hypoalbuminemia, Clinical studies

CLC Number: 

  • R576.1

Tab 1

Comparison of early complications in 2 groups [cases (%)]"

Group n ARDS Renal dysfunction Shock Cardiovascular
Hepatic failure Gastrointestinal
Mild hypoalbuminemia 54 27 (50.0) 10 (18.5) 6 (11.1) 8 (14.8) 24 (44.4) 2 (3.7)
Severe hypoalbuminemia 84 55 (65.5) 35 (41.7)** 32 (38.1)** 35 (41.7)** 39 (46.4) 20 (23.8)**

Tab 2

Comparison of early relative parameters in 2 groups (to be continued) ($\bar{x}$±s )"

Group n Pulse rate (bpm) Body temperature (℃) Respiratory rate (bpm) LDH (U/L) Glucose (mmol/L)
Mild hypoalbuminemia 54 118.00±17.35 37.93±0.95 31.34±8.04 634.08±327.00 15.33±7.08
Severe hypoalbuminemia 84 134.67±29.14** 38.77±0.98 36.27±8.39** 845.06±608.60* 14.94±7.45
Group n Ca2+ (mmol/L) Triglyceride (mmol/L) Ranson score APACHEⅡ score Balthazar CT score
Mild hypoalbuminemia 54 1.74±0.35 3.79±4.06 4.77±1.62 9.84±4.20 6.23±2.19
Severe hypoalbuminemia 84 1.50±0.46** 3.25±3.74 5.10±1.81 11.71±5.37* 7.08±2.50
[1] 刘续宝, 蒋俊明, 黄宗文 , 等. 中西医结合治疗重症急性胰腺炎的临床研究(附1367例报道)[J]. 四川大学学报(医学版), 2004,35(2):204-208
[2] Toouli J, Brooke-Smith M, Bassi C , et al. Guidelines for the management of acute pancreatitis[J]. J Gastroenterol Hepatol, 2002,17(Suppl):S15-S39
doi: 10.1046/j.1440-1746.17.s1.2.x
[3] Mizuguchi T, Mukaiya M, Imaizumi H , et al. Successful management of severe acute pancreatitis with multiple organ failure[J]. Pancreas, 2004,28(2):211-213
doi: 10.1097/00006676-200403000-00014
[4] 严燕国, 艾中立, 刘志苏 , 等. 当归注射液对重症急性胰腺炎胰肾损害的保护作用[J]. 肝胆胰外科杂志, 2000,12(2):87-89
[1] Qi-ming Xue, Lu Huang, Ning Li. Effects of electroacupuncture at Tianshu (ST25) on pro- and anti-inflammatory cytokines in rats with severe acute pancreatitis. Journal of Chinese Integrative Medicine, 2011, 9(6): 658-664.
[2] Yan-yi Ren, Han-lin Gong, Wen-Fu Tang, Mei-hua Wan, Jian-lei Zhao, Xi Huang. Dachengqi Decoction induces pancreatic acinar cell apoptosis in experimental acute pancreatitis in rats. Journal of Chinese Integrative Medicine, 2009, 7(7): 651-.
[3] Deng-hao Liu, Zheng Wang, Zhang-yan Qin. Clinical effects of Shugan Jianpi Recipe on postadolescent acne in women. Journal of Chinese Integrative Medicine, 2009, 7(7): 671-673.
[4] Xiao-nan Yang, Li-hui Deng, Ping Xue, Long Zhao, Tao Jin, Mei-hua Wan, Qing Xia. Non-preventive use of antibiotics in patients with severe acute pancreatitis treated with integrated traditional Chinese and Western medicine therapy: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2009, 7(4): 330-333.
[5] Yue Ma, Zong-wen Huang, Qing Xia, Ping Xue, Jia Guo, Hong-qiang Wei, Yan Chen, Fu-qian He, Zheng-yu Cheng, Zi-qi Lin. Influence of integrated traditional Chinese and Western medicine therapy on serum resistin levels in patients with severe acute pancreatitis: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2009, 7(12): 1134-1138.
[6] Jian-wen Ning, Feng Ji, Dan-dong Luo, Chun-yan Yang, Li-jun Wang. Effects of emodin on cell apoptosis of intestinal mucosa and serum leptin in rats with severe acute pancreatitis. Journal of Chinese Integrative Medicine, 2009, 7(12): 1167-1173.
[7] Jing-yun Fan, Zong-wen Huang, Jia Guo. Value of four scoring systems for predicting prognosis of severe acute pancreatitis. Journal of Chinese Integrative Medicine, 2009, 7(1): 34-40.
[8] Min Zhang, De-zeng Zhu, Zhao-shen Li, Xian-bao Zhan. Red peony root decoction in treatment of severe acute pancreatitis: a randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(6): 569-575.
[9] Jia Guo, Zong-wen Huang, Jing-yun Fan, Yan chen, Fu-qian He. Risk factor analysis of severe acute pancreatitis complicated by pancreatic encephalopathy. Journal of Chinese Integrative Medicine, 2008, 6(4): 352-354.
[10] Ping Xie, Li-hui Deng, Zhao-da Zang, Qing Xia, Zong-wen Huang, Xiao-nan Yang, Jun-ming Jiang. Clinical study of Yihuo Qingxia method in treating hyperlipoidemia-related severe acute pancreatitis in early stage. Journal of Chinese Integrative Medicine, 2008, 6(3): 262-265.
[11] Li-hui Dang, Xiao-nan Yang, Qing Xia. Protective effects of Chaiqin Chengqi Decoction on isolated pancreatic acinar cells in acute pancreatitis rats and the mechanisms. Journal of Chinese Integrative Medicine, 2008, 6(2): 176-179.
[12] Yong-hong Li, Zong-wen Huang, Ping Xue, Jia Guo, Fu-qian He, Zheng You, Zheng-rong Wang. Effects of Chaiqin Chengqi Decoction on activation of nuclear factor-κB in pancreas of rats with acute necrotizing pancreatitis. Journal of Chinese Integrative Medicine, 2008, 6(2): 180-184.
[13] Ping Xue, Li-hui Deng, Zhao-da Zhang, Xiao-nan yang, Qing Xia, Da-kai Xiang, Lei Huang, Mei-hua Wan, Hai-yan Zhang. Chaiqin Chengqi Decoction decreases pancreatic acinar cell calcium overload in rats with acute pancreatitis. Journal of Chinese Integrative Medicine, 2008, 6(10): 1054-1058.
[14] Yan-hui Sun, Yong-qing Cao, Jin-gen Lu, Hong-xiang Huang, Xiu-tian Guo. Internal opening incision with harmonic scalpel, remaining and tunnel thread-dragging methods in surgical management of posterior horseshoe fistula. Journal of Chinese Integrative Medicine, 2007, 5(5): 589-591.
[15] Li-xin Xiao, Jin-gen Lu. Clinical observation of suspended ligation and Milligan-Morgan hemorrhoidectomy in surgical management of circumferential mixed hemorrhoids. Journal of Chinese Integrative Medicine, 2007, 5(4): 460-462.
Full text



[1] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. An explanation on "guiding principles of clinical research on mild cognitive impairment (protocol)". Journal of Chinese Integrative Medicine, 2008, 6(1): 15-21
[2] Jin-rong Fu. Establishment of multivariate diagnosis and treatment system of modern gynecology of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 22-24
[3] A-gao Zhou, Yong Zhang, Gang Kui, De-Yun Kong, Hai-liang Ge, Qiu-hua Ren, Jia-rong Dong, Sheng Hong, Xu-ming Mao, Yin Wang, Hui-zheng Zhang, Shu-jun Wang. Influence of traditional Chinese compound recipes with different efficacy on body weight, tumor weight and immune function in H22 cancer-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 77-82
[4] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022
[5] Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239
[6] Nian-hong Wang , Jun-tao Yan , Wu-quan Sun , Yong-shan Hu , Jun Xia , Li-cheng Wei , Jie Jia , Gui-lin Ouyang , Yong He , Yan-ming Guo , Jie Xu . Effects of early application of Tuina treatment on quadriceps surface myoelectricity in patients after total knee arthroplasty: a randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(11): 1247-1253
[7] Liang-ping Hu, Xiao-lei Bao, Li-xin Tao, Shi-guo Zhou, Xue Guan. Estimation of sample size and testing power (Part 2). Journal of Chinese Integrative Medicine, 2011, 9(11): 1185-1189
[8] Shu Yang, Xin-yue Wang, Shan Jing, Xue Yang, Yi-hua Sheng, Xin Yan. Crohn disease in rats induced by different concentrations of trinitrobenzenesulfonic acid and ethanol. Journal of Chinese Integrative Medicine, 2011, 9(11): 1242-1247
[9] Mei-jun Lü, Hui-yong Zhang, Zhe Zhang, Guan-lin Yang. Measurement of health-related quality of life in coronary heart disease: A review. Journal of Chinese Integrative Medicine, 2011, 9(12): 1277-1285
[10] Shuo Zhang , Hong-cai Shang. Correlation between traditional Chinese medicine syndromes and omics: A literature review. Journal of Chinese Integrative Medicine, 2011, 9(12): 1286-1291