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Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (6): 634-638.doi: 10.3736/jcim20060619

• Original Experimental Research • Previous Articles     Next Articles

Effects of Yiweining Recipe on expressions of metalloproteinase-2 and cyclooxygenase-2 mRNAs in ectopic endometrium of rats with endometriosis

Fan Qu1,Jue Zhou2,Dong-Xia Yang1,Wen-guang Ma1,Bao-zhang Ma1   

  1. 1. Department of Gynecology and Obstetrics, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province 150040, China
    2. College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang Province 150040, China
  • Online:2006-11-30 Published:2006-11-15

Objective

To explore the effects of Yiweining Recipe (YWNR), a compound Chinese herbal medicine, on expressions of metalloproteinase-2 (MMP-2) and cyclooxygenase-2 (COX-2) mRNAs in rats with endometriosis (EM).

Methods

Operational self-transplantation was applied in establishing the rat models. Detection of MMP-2 and COX-2 mRNAs was conducted with hybridization in situ.

Results

There were significant differences in the expressions of MMP-2 and COX-2 mRNAs between the untreated group and the high-dose YWNR-treated group. YWNR could reduce the expressions of MMP-2 and COX-2 mRNAs.

Conclusion

YWNR can treat EM through reducing the positive expressions of MMP-2 and COX-2 mRNAs.

Key words: Endometriosis, Matrix metalloproteinase-2, Cyclooxygenase-2, Rats

CLC Number: 

  • R71

"

GroupnNumber of cases that exhibits various staining conditions
of the positive cells representing the positive expression of MMP-2 mRNA
Score
++++++
Normal control925209**
Untreated9022521
High-dose YWNR-treated9243010*
Low-dose YWNR-treated9152112
Danazol-treated9233112

"

GroupnNumber of cases that exhibits various staining conditions
of the positive cells representing the positive expression of COX-2 mRNA
Score
++++++
Normal control962104**
Untreated9023420
High-dose YWNR-treated935107*
Low-dose YWNR-treated9242111**
Danazol-treated9151112**
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