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Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (4): 465-469.doi: 10.3736/jcim20070422

• Literature Review • Previous Articles     Next Articles

Research on the chemical constituents and pharmacological activities of Liriope Lour.

Tao Jiang1,2, Lu-ping Qin1   

  1. 1. Department of Pharmacogonosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
    2. Shanghai Nabio Biotechnology Co., Ltd, Shanghai 201203, China Abstract
  • Online:2007-07-31 Published:2007-05-15

Key words: plants, chemical principle, pharmacology

CLC Number: 

  • R931.71

"

编号 名称 来源 参考文献
1 ruscogenin3-O-α-L-rhamnopyranoside a 2
2* 25(S)-ruscogenin1-O-β-D-fucopyranoside-3-O-α-L-rhamnopyranoside(Ls-2) a, b 2, 3, 4
3 25(S)-ruscogenin1-O-α-L-rhamnopyranosyl(1→2)-β-D-fucopyranoside a, b 2, 3
4 ruscogenin3-O-β-D-glucopyranosyl(1→3)-α-L-rhamnopyranoside a2
5 3-O-[α-L-rhamnopyranoside(1→2)][β-D-xylopyranosyl(1→3)]-β-D-glucopyranosides of diosgenin and yamogenin a 2
6 3-O-β-chacotriosides of diosgenin and yamogenin a 2
7 ruscogenin1-sulfate 3-O-α-L-rhamnopyranoside a 2
8 26-O-β-D-glucopyranosyl-22-O-methylfurost-5-ene-3β, 26-diol 3-O-β-chacotrioside a 2
9 25(S)-鲁斯可皂苷元-1-O-[α-L-吡喃鼠李糖基(1→2)][β-D-吡喃木糖基(1→3)]-β-D-吡喃夫糖苷 b, c 3, 5
10 β-sitosterolβ-D-glucopyranoside (Ls-1, Lm-1) b, c 4
11* 25(S)-ruscogenin1-O-β-D-xylopyranosido-3-O-α-L-rhamnopyranoside (Ls-3) b 4
12* 25(S)-ruscogenin1-O-α-L-rhamnopyranosyl(1→2)-β-D-xylopyranoside (Ls-4) b 4
13* 25(S)-ruscogenin1-O-[(2-O-acetyl)-α-L-rhamnopyranosyl(1→2)][β-D-xylopyranosyl(1→3)]-β-D-fucopyranoside (Ls-5 ) b 4
14* 25(S)-ruscogenin1-O-[(3-O-acetyl)-α-L-rhamnopyranosyl(1→2)][β-D-xylopyranosyl(1→3)]-β-D-fucopyranoside (Ls-6) b 4
15* yamogenin3-O-[α-L-rhamnopyranosyl(1→2)][β-D-xylopyranosyl(1→3)]-β-D-glucopyranoside (Ls-7) b 4
16* ruscogenin1-O-β-D-glucopyranosyl(1→2)]-β-D-fucopyranoside (Lm-2) c 4
17* ruscogenin1-O-[β-D-glucopyranoside(1→2)][β-D-xylopyranosyl(1→3)]-β-D-fucopyranoside (Lm-3) c 4
18* 25(S)-ruscogenin-1-O-[α-L-rhamnopyranosyl(1→2)][β-D-xylopyranosyl(1→3)]-β-D-fucopyranoside-3-O-α-L-rhamnopyranoside (Lirioproliosode A) b 5
19* 25(S)-ruscogenin-1-O-[3-O-acetyl-α-L-rhamnopyranosyl(1→2)]-β-D-fucopyranoside (Lirioproliosode B) b 5
20* 25(S)-ruscogenin(1-O-[2-O-acetyl-α-L-rhamnopyranosyl(1→2)]-β-D-fucopyranoside (Lirioproliosode C) b 5
21* ruscogenin(1-O-[2-O-acetyl-α-L-rhamnopyranosyl(1→2)]-β-D-fucopyranoside (Lirioproliosode D) b 5
22* 25(S)-ruscogenin1-O-β-D-fucopyranoside (Lm-4) c 6
23* pennogenin3-O-[4’-O-acetyl-α-L-rhamnopyranosyl(1→3)]-β-D-xylopyranosyl(1→4)]-β-D-glucopyranoside (Lm-5) c 6
24 25(R)鲁斯可皂苷元-1-O-β-D-吡喃葡萄糖-(1→2)-β-D-吡喃岩藻糖苷 c 7
25 25(R)鲁斯可皂苷元-1-O-β-D-吡喃木糖-(1→3)-β-D-吡喃岩藻糖苷 c 7
26 香草酸 c 7
27 对羟基桂皮酰酪胺 c 7
28 谷氨酸酐 c 7
29 熊果酸 c 7
30 齐墩果酸 c 7
31 正二十五烷酸 c 7
32 正三十一烷酸 c 7
33 门冬氨酸 d 8
34 苏氨酸 d 8
35 丝氨酸 d 8
36 丙氨酸 d 8

Figure 1

Structure of new saponin compounds"

[1] 余伯阳, 徐国钧 . 中药麦冬的资源利用研究[J]. 中草药, 1995,26(4):205-210
Yu BY, Xu GJ . Studies on resource utilization of Chinese drug dwarf lilyturf(Ophiopogon japonicus)[J]. Zhong Cao Yao, 1995,26(4):205-210
[2] 刘伟, 王著禄, 梁华清 . 湖北山麦冬化学成分的研究[J]. 药学学报, 1989,24(10):749-754
Liu W, Wang ZL, Liang HQ . Studies on the chemical constituents of Liriope spicata(Thunb.) Lour. var. proliferae Y. T. Ma[J]. Yao Xue Xue Bao, 1989,24(10):749-754
[3] Yoshiaki W, Shuichi S, Yoshitera I , et al. Comparative studies on the constituents of ophiopogonis tuber and its congeners. I: Studies of the constituents of the subterranean part of Liriope platyphylla Wang and Tang[J]. Chem Pharm Bull, 1983,31(6):1980-1990
[4] Yu BY, Hirai Y, Shoji J , et al. Comparative studies on the constituents of ophiopogonis tuber and its congeners. VI. Studies on the constituents of the subterranean part of Liriope spicata var. prolifera and L. muscari.(1)[J]. Chem Pharm Bull, 1990,38(7):1931-1935
[5] Yu BY, Qiu SX, Zaw K , et al. Steroidal glycosides from the subterranean parts of Liriope spicata var. prolifera[J]. Phytochemistry, 1996,43(1):201-206
doi: 10.1016/0031-9422(96)00228-2 pmid: 8987515
[6] Chen ZH, Wu T, Guo YL , et al. Two new steroidal glycosides from Liriopes muscari.(Decne.) Beilg[J]. Chin Chem Lett, 2006,17(1):31-34
[7] 程志红, 吴韬, 余伯阳 , 等. 短葶山麦冬化学成分的研究[J]. 中草药, 2005,36(6):823-826
Cheng ZH, Wu T, Yu BY , et al. Studies on the chemical constituents of Liriopes muscari.(Decne.) Beilg[J]. Zhong Cao Yao, 2005,36(6):823-826
[8] 吴秀英, 谢继红, 王唯玮 , 等. 山麦冬水溶性成分的研究[J]. 大连医学院学报, 1989,11(1):43-46
Wu XY, Xie JH, Wang WW , et al. Studies on the water-soluble active constituents of Liriope spicata(Thunb.) Lour. var. proliferae Y.T. Ma[J]. Dalian Yi Xue Yuan Xue Bao, 1989,11(1):43-46
[9] 高广猷, 李云勋, 段鹏 , 等. 山麦冬的水溶性提取物对麻醉猫血流动力学的影响[J]. 中国中药杂志, 1989,9(40):552-554
Gao GY, Li YX, Duan P , et al. Haemodynamic effects of water-soluble extract of Liriope spicata(Thunb.) Lour. var. proliferae Y.T. Ma on anaesthetized cat[J]. Zhongguo Zhong Yao Za Zhi, 1989,9(40):552-554
[10] 桂苡, 高广猷, 韩国柱 , 等. 山麦冬对心血管系统药理作用的研究[J]. 中草药, 1984,15(3):21-23
Gui Y, Gao GY, Han GZ , et al. Experimental observation on the effects of cardiovascular of Liriope spicata(Thunb.) Lour. var. proliferae Y. T. Ma[J]. Zhong Cao Yao, 1984,15(3):21-23
[11] 高广猷, 李淑媛, 王勖 . 山麦冬水溶性提取物抗心肌缺血作用的实验观察[J]. 大连医学院学报, 1985,7(3):25-27
Gao GY, Li SY, Wang X . Experimental observation on the effects of anti-myocardial ischemia of Liriope spicata(Thunb.) Lour. var. proliferae Y.T. Ma water soluble extract[J]. Dalian Yi Xue Yuan Xue Bao, 1985,7(3):25-27
[12] 高广猷, 宋晓亮, 叶丽虹 . 山麦冬总氨基酸对大鼠实验性心肌缺血的保护作用[J]. 中国药理学通报, 1993,9(4):281-284
Gao GY, Song XL, Ye LH . Effect of total amino acid of Liriope spicata(Thunb.) Lour. var. proliferae Y.T. Ma on experimental myocardial ischemia[J]. Zhongguo Yao Li Xue Tong Bao, 1993,9(4):281-284
[13] 宋晓亮, 高广猷, 叶丽虹 . 山麦冬总皂苷对实验性心肌缺血的影响[J]. 中国药理学通报, 1996,12(4):329-332
Song XL, Gao GY, Ye LH . Effects of total saponin of Liriope spicata(Thunb.) Lour. var. proliferae Y. T. Ma on experimental myocardial ischemia[J]. Zhongguo Yao Li Xue Tong Bao, 1996,12(4):329-332
[14] 余伯阳, 殷霞, 徐国钧 . 短葶山麦冬的药理活性研究[J]. 中草药, 1991,14(4):37-39
Yu BY, Yin X, Xu GJ . Research on the pharmacological activities of Liriopes muscari.(Decne.) Beilg[J]. Zhong Cao Yao, 1991,14(4):37-39
[15] 余伯阳, 殷霞, 徐国钧 , 等. 湖北麦冬与浙麦冬质量的研究——免疫活性比较[J]. 中国中药杂志, 1991,16(10):584-585
Yu BY, Yin X, Xu GJ , et al. Comparison of immunological activities between the Liriope spicata(Thunb.) Lour. var. proliferae Y. T. Ma and Zhejiang Province Ophiopogon japonicus(L. f.) Ker-Gawl.(O. chekiangensis K. Kimura)[J]. Zhongguo Zhong Yao Za Zhi, 1991,16(10):584-585
[16] 余伯阳, 殷霞, 荣祖元 , 等. 短葶山麦冬皂苷C的药理活性研究[J]. 中国药科大学学报, 1994,25(5):286-288
Yu BY, Yin X, Rong ZY , et al. Pharmacological activities of ruscogenin 1-O-[β-D-glucopyranoside(1→2)] [β-D-xylopyranosyl(1→3)]-β-D-fucopyranoside from tubers roots of Liriope muscari(Decne.) Bailey[J]. Zhongguo Yao Ke Da Xue Xue Bao, 1994,25(5):286-288
[17] Wu FH, Cao JS, Jiang JJ , et al. Ruscogenin glycoside(Lm-3) isolated from Liriope muscari improves liver injury by dysfunctioning liver-infiltrating lymphocytes[J]. J Pharm Pharmacol, 2001,( 53):681-688
[18] 徐强, 王蓉, 余伯阳 . 短葶山麦冬皂苷C对迟发型变态反应及炎症反应的影响[J]. 中国药科大学学报, 1993,24(2):98-101
Xu Q, Wang R, Yu BY . Effects of ruscogenine fucopyranoside on the delayed type hypersensitivity and inflammatory reactions[J]. Zhongguo Yao Ke Da Xue Xue Bao, 1993,24(2):98-101
[19] Hur J, Lee P, Kim J , et al. Induction of nerve growth factor by butanol fraction of Liriope platyphylla in C6 and primary astrocyte cells[J]. Bio Pharm Bull, 2004,27(8):1257-1260
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