Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (12): 1107-1113.doi: 10.3736/jcim20101201

Special Issue: Traditional Chinese Medicine

• Review • Previous Articles     Next Articles

Thinking and practice on research of effective components of traditional Chinese medicine compound prescriptions

 Chang-qing Deng   

  1. College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China
  • Received:2010-08-30 Accepted:2010-09-13 Online:2010-12-20 Published:2010-08-15
  • Contact: Chang-qing Deng E-mail:dchangq@sohu.com

By analyzing current research status and considering our own previous research results, we hold that research on active substance of Chinese herbal formula should be focused on the effect of active components according to its functions, thus determining the main effective components of traditional Chinese medicine (TCM) compound prescriptions. Study of compatibility of effective components should be carried out and compound prescriptions composed of effective components should be developed. It is a pivotal way to deepen research on active components of TCM compound prescription by further analyzing the compatibility of effective components and the relationship between functional components and active components by multilink and multitarget methods.

Key words: Compounds (TCD), Effective components, Research design

[1] Yu YH . Theory of compatibility of formulas in traditional Chinese medicine is of systematic and scientific value. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi. 2004 ; 10(8):63-64. Chinese.
于友华 . 方剂配伍理论的系统科学思想. 中国中医基础医学杂志. 2004; 10(8):63-64.
[2] Normile D . Asian medicine. The new face of traditional Chinese medicine. Science. 2003; 299(5604):188-190.
doi: 10.1126/science.299.5604.188
[3] Luo GA, Liang QL, Liu QF, Zhang RL, Yang HH, Li X, Wang YM, Jia W, Zhang WD, Zhang C, Li YK, . Chemomics-integrated global systems biology: a holistic methodology of study on compatibility and mechanism of formulas in traditional Chinese medicine . Shi Jie Ke Xue Ji Shu Zhong Yi Yao Xian Dai Hua. 2007 ; 9(1):10-15. Chinese with abstract in English.
罗国安, 梁琼麟, 刘清飞, 张荣利, 杨辉华, 李雪, 王义明, 贾伟, 张卫东, 张川, 李贻奎 . 整合化学物质组学的整体系统生物学——中药复方配伍和作用机理研究的整体方法论. 世界科学技术中医药现代化. 2007; 9(1):10-15.
[4] Jia WG . Post-absorption/metabolism multicompound drug : a new approach to modernization of Chinese herbal medicine . J Chin Integr Med. 2006; 4(5):441-446. Chinese with abstract in English.
贾韦国 . 吸收与代谢后寡单体复合药物——中药现代化的新尝试. 中西医结合学报. 2006; 4(5):441-446.
[5] Du GH. Overview of effective compounds group formulaion in traditional Chinese medical prescription . Zhong Cheng Yao. 2002; 24(11) : 878-880. Chinese with abstract in English.
杜冠华 . 中药复方有效成分组学研究. 中成药. 2002; 24(11) : 878-880.
[6] Gao YH, Xing YW, Yuan ZZ, Zhu LQ, Li PT , Wang SR . Effects of Qingkailing effective components on nuclear factor-kappa B in an ischemia-reperfusion injury model of rat brain microvascular endothelial cells in vitro. J Chin Integr Med. 2009; 7(2) : 135-139. Chinese with abstract in English.
高永红, 邢雁伟, 袁拯忠, 朱陵群, 李澎涛, 王硕仁 . 清开灵有效组分对大鼠微血管内皮细胞体外缺血再灌注损伤模型核转录因子-kB的影响.中西医结合学报. 2009; 7(2) : 135-139.
[7] Gao YH, Niu FL, Zhu LQ, Li PT , Wang SR . Effect of Qingkailing effective components on MMP-9 mRNA expression of an in vitro ischemia and reperfusion injury model of rat brain microvascular endothelial cell . Liaoning Zhong Yi Za Zhi. 2007; 34(12):1806-1808. Chinese with abstract in English.
髙永红, 牛福玲, 朱陵群, 李澎涛, 王硕仁 . 清开灵有效组分调控大鼠脑MVEC缺血再灌注损伤MMP-9 mRNA表达的研究.辽宁中医杂志. 2007; 34(12):1806-1808.
[8] Chu SL, Wang XM, Fu H , Liu GX . Effects of Jiawei Wuzi Yanzong pill and its components on central cholinergic system in mice with learning and memory disorders induced by scopolamine . Zhongguo Zhong Yi Yao Xin Xi Za Zhi. 2006; 13(2):18-19. Chinese with abstract in English.
褚松龄, 王学美, 富宏, 刘庚信 . 加味五子衍宗方及其有效组分对记忆障碍小鼠中枢胆碱能系统的影响. 中国中医药信息杂志. 2006; 13(2):18-19.
[9] Chu SL, Liu GX, Wang XM . Effects of modified Wuzi Yanzong prescription and its components on spatial behavior in mice with learning and memory disorders. Zhongguo Zhong Xi Yi Jie He Ji Jiu Za Zhi. 2005; 12(5):271-274. Chinese with abstract in English.
褚松龄, 刘庚信, 王学美 . 加味五子衍宗方及其有效组分对记忆障碍小鼠空间行为的影响.中国中西医结合急救杂志. 2005; 12(5):271-274.
[10] Wang B , Wang XM . Protective effects of Jiawei Wuzi Yanzong prescription and its components on H2 02 induced PCI2 cell injuries. Zhongguo Shi Yan Fang Ji Xue Za Zhi. 2009; 15(8) : 57-60. Chinese.
王斌, 王学美 . 加味五子衍宗方及其有效部位对h2o2 损伤PC12细胞的保护作用.中国实验方剂学杂志. 2009; 15(8) : 57-60.
[11] Liu JG, Dong GJ, Shi DZ , Wang YY . Effects of components of water extract from Qixue Bingzhi Fang on atherosclerotic unstable plaque of apolipoprotein E deficient mice. Zhongguo Yao Li Xue Yu Du Li Xue Za Zhi. 2008; 22(4) : 263-269. Chinese with abstract in English.
doi: 10.3867/j.issn.1000-3002.2008.04.004
刘剑刚, 董国菊, 史大卓, 王永炎 . 气血并治方有效组分对载脂蛋白E基因敲除小鼠动脉粥样硬化不稳定斑块的干预作用.中国药理学与毒理学杂志. 2008; 22(4) : 263-269.
doi: 10.3867/j.issn.1000-3002.2008.04.004
[12] Ji B, Geng P, Liu JG, Shi DZ , Wang YY . Effects of active components extracted from Qixue Bingzhi Recipe on proliferation of vascular smooth muscle cells and expressions of platelet-derived growth factor and its receptor genes . J Chin Integr Med. 2006; 4(1) : 30-34. Chinese with abstract in English.
稽波, 耿萍, 刘剑刚, 史大卓, 王永炎 . 气血并治方有效组分配伍对平滑肌细胞增殖和血小板源生长因子及其受体基因表达的影响.中西医结合学报. 2006; 4(1) : 30-34.
[13] Wang XJ, Zhang N, Sun H, Li LJ, Lu HT. Protective effect of Liuwei Dihuang Wan and its constituents absorbed into blood after oral administration on hydrocortisone inducing renal deficiency in rat. Zhongguo Shi Yan Fang Ji Xue Za Zhi. 2008; 14(2):33-37. Chinese with abstract in English.
王喜军, 张宁, 孙晖, 李丽静, 吕海涛 . 六味地黄丸血中移行成分对氢化可的松致大鼠肾虚动物模型的保护作用.中国实验方剂学杂志. 2008; 14(2):33-37.
[14] Yang N, Meng XL , Xiong YX . Effect of different compatibilities of effective fraction of Xie-Xin decoction on NF-icB and IicB expression of lung injury rats induced by LPS. Zhongguo Yao Li Xue Tong Bao. 2007 ; 23(11):1441-1443. Chinese with abstract in English.
杨娜, 孟宪丽, 熊玉霞 . 泻心汤有效组分不同配伍对内毒素肺损伤大鼠NF-KB及LcB表达的影响.中国药理学通报. 2007; 23(11):1441-1443.
[15] Meng XL, Xiong YX, Yang N, Zhang Y, He YM. Effect of the compatibility of active components of Xie- Xin Decoction on activated peritoneal macrophages induced by LPS. Zhong Yao Yao Li Yu Lin Chuang. 2007 ; 23(5):27-30. Chinese with abstract in English.
孟宪丽, 熊玉霞, 杨娜, 张艺, 何毓敏 . 泻心汤有效组分配伍对脂多糖诱导的大鼠腹腔巨噬细胞活化的影响 . 中药药理与临床. 2007; 23(5):27-30.
[16] Tang YH, Deng CQ, Liu WH, Zhang QY, Li H , He FY . Effect of four kinds of active fractions of Buyang Huanwu Decoction on cerebral infarction volume in focal cerebral ischemia rats. Zhong Cao Yao. 2005; 36(2):236-239. Chinese with abstract in English.
唐映红, 邓常青, 刘旺华, 张秋雁, 李花, 贺福元 . 补阳还五汤4类有效部位对局灶性脑缺血大鼠脑梗死体积的影响.中草药. 2005; 36(2):236-239.
[17] Tang YH, Chen RF, Li H, Chen BY , Deng CQ . Effect of active fraction of Buyang Huanwu decoction on IL-ip and ICAM-1 expression in cerebral ischemia reperfusion in rats. Hunan Zhong Yi Xue Yuan Xue Bao. 2005; 25(5):5-11. Chinese with abstract in English.
唐映红, 陈瑞芬, 李花, 陈北阳, 邓常青 . 补阳还五汤有效部位对脑缺血再灌注大鼠IL-1β和ICAM-1表达的作用.湖南中医学院学报. 2005; 25(5):5-11.
[18] Tang YH, Li H, Chen BY, Chen RF, Deng CQ . Effect of active fraction of Buyang Huanwu Decoction on caspase expression in rats after focal cerebral ischemic reperfusion . Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006; 26(6):533-537. Chinese with abstract in English.
唐映红, 李花, 陈北阳, 陈瑞芬, 邓常清 . 补阳还五汤有效部位对局灶性脑缺血再灌注后caspase表达的影响 .中国中西医结合杂志. 2006; 26(6):533-537.
[19] Zhang SP, Liang Y, Deng CQ. Effect of Buyang Huanwu Decoction and its active fractions on expression of IL-ip and associate factor after cerebral ischemia reperfusion in rats . Hunan Zhong Yi Yao Da Xue Xue Bao. 2007 ; 27(2):24-27. Chinese with abstract in English.
张淑萍, 梁燕, 邓常青 . 补阳还五汤和其有效部位对大鼠脑缺血再灌注后IL-1β及相关因子表达的影响.湖南中医药大学学报. 2007; 27(2):24-27.
[20] Zhang SP, Ling Y, Deng CQ . Effect of Buyang Huanwu Decoction and its active fractions on caspase expression after cerebral ischemia-reperfusion in rats. Zhong Cao Yao. 2006; 37(7) : 1041-1045. Chinese with abstract in English.
张淑萍, 梁燕, 邓常青 . 补阳还五汤及其有效部位对大鼠脑缺血再灌注后caspase表达的影响.中草药. 2006; 37(7) : 1041-1045.
[21] Liang Y, Zhang SP , Deng CQ . Effect of Buyang Huanwu Decoction and its basis fractions on arterial thrombosis in mice. Xue Shuan Yu Zhi Xue Xue. 2005; 11(4):154-156. Chinese with abstract in English.
梁燕, 张淑萍, 邓常青 . 补阳还五汤及其主要有效部位对小鼠动脉血栓形成的影响.血栓与止血学. 2005; 11(4):154-156.
[22] Yang J, Liang Y, Zhang SP, Deng CQ . Effect of Buyang Huanwu Decoction and its active fractions such as alkaloid and glycoside on TXA2 and PGI2 of arterial thrombosis model in rats. Zhongguo Shi Yan Fang Ji Xue Za Zhi. 2006; 12(8):28-30. Chinese with abstract in English.
杨静, 梁燕, 张淑萍, 邓常青 . 补阳还五汤及有效部位生物碱和苷对动脉血栓形成大鼠血浆血栓素A2、前列环素的影响.中国实验方剂学杂志. 2006; 12(8):28-30.
[23] Tang YH, Liang Y, Zhang SP, Yang J, Deng BX, Deng CQ . Effect of Buyang Huanwu Decoction and its alkaloid and glycoside on anticoagulative system arterial thrombosis rat. Zhongguo Shi Yan Fang Ji Xue Za Zhi. 2007 ; 13(6):39-42. Chinese with abstract in English.
唐映红, 梁燕, 张淑萍, 杨静, 邓冰湘, 邓常青 . 补阳还五汤及其有效部位生物碱和苷对动脉血栓形成大鼠抗凝系统活性的影响.中国实验方剂学杂志. 2007; 13(6):39-42.
[24] Ou ME, Tang LW, .Deng CQ Effect of Buyang Huanwu Decoction and its active fraction on antithrombosis in cultured vascular endothelial cells and protein kinase C . Zhong Cao Yao. 2008; 39(10) : 1514-1520. Chinese with abstract in English.
欧明娥, 唐利文, 邓常清 . 补阳还五汤有效组分对血管内皮细胞抗血栓功能及蛋白激酶C的影响. 中草药. 2008; 39(10) : 1514-1520.
[25] Ou ME, Tang LW, Li H, Deng CQ .Effect and signal transduction mechanism of active components of Buyang Huanwu Decoction on vascular adhesion molecule expression . Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009; 29(5):430-434. Chinese with abstract in English.
欧明娥, 唐利文, 李花, 邓常清 . 补阳还五汤有效组分对血管内皮细胞黏附分子表达的影响及其信号转导机制.中国中西医结合杂志. 2009; 29(5):430-434.
[26] Wu L, Zhang W, Li H, Zhang GM, Chen BY, Tang YH, Deng CQ. Effects of Buyang Huanwu Decoction and itsalkaloids and glycosides on aortic intimal hyperplasia and expression of proliferating cell nuclear antigen in rats with aortic intimal injuries . J Chin Integr Med. 2008; 6(8) : 836-842. Chinese with abstract in English.
吴露, 张伟, 李花, 张国民, 陈北阳, 唐映红, 邓常清 . 补阳还五汤及其有效组分生物碱和苷对大鼠血管内膜增生和增殖细胞核抗原表达的影响. 中西医结合学报. 2008; 6(8) : 836-842.
[27] Zhang W, Wu L, Chen BY, Zhang GM, Tang YH, Deng CQ . Effects of Buyang Huanwu Decoction and its effective components on extracellular matrix of intimal hyperplasia and its correlation factors in rats. Zhongguo Bing Li Sheng Li Za Zhi. 2010; 26(1):169-173. Chinese with abstract in English.
doi: 1000-4718
张伟, 吴露, 陈北阳, 张国民, 唐映红, 邓常清 . 补阳还五汤及有效组分对大鼠增生血管内膜细胞外基质蛋白表达的影响. 中国病理生理杂志. 2010; 26(1):169-173.
doi: 1000-4718
[28] Wu L, Zhang W, Li H, Chen BY, Zhang GM, Tang YH, He FY, Deng CQ . Inhibition of aortic intimal hyperplasia and cell cycle protein and extracellular matrix protein expressions by BuYang HuanWu Decoction.[J] Ethnopharmacol. 2009 ; 125(3) : 423-435.
doi: 10.1016/j.jep.2009.07.022
[29] Li H, Chen G, Deng CQ . Effects of plasma containing Buyang Huanwu Decoction and its effective components and total Panax notoginseng saponins on vascular smooth muscle cell proliferation induced by platelet- derived growth factor. J Chin Integr Med. 2009 ; 7(11):1078-1085. Chinese with abstract in English.
李花, 陈刚, 邓常清 . 补阳还五汤及其有效组分和三七总皂苷含药血浆抗血小板衍生生长因子诱导的血管平滑肌细胞增殖的作用.中西医结合学报. 2009; 7(11):1078-1085.
[30] Chen G, Wu L, Deng CQ . The efects of BuYang HuanWu Decoction and its effective components on proliferation-related factors and EPK1/2 signal transduction pathway in cultured vascular smooth muscle cells. J Ethnopharmacol.In press.
[31] Jia XB, Chen Y, Li X, Tan XB, Fan CY, Li LD . New thoughts and methods of studying material base of traditional Chinese herbal formula. Zhonghua Zhong Yi Yao Za Zhi. 2008; 23(5) : 420-425. Chinese with abstract in English.
贾晓斌, 陈彦, 李霞, 谭晓斌, 范晨怡, 李连达 . 中药复方物质基础研究新思路和方法.中华中医药杂志. 2008; 23(5) : 420-425.
[1] Bing He, Ge Zhang, Ai-ping Lu. Integrative network analysis: Bridging the gap between Western medicine and traditional Chinese medicine. Journal of Integrative Medicine, 2015, 13(3): 133-135.
[2] Liang-ping Hu, Xiao-lei Bao, Chen-long Lv. Two-factor designs unable to examine the interactions (Part 2). Journal of Chinese Integrative Medicine, 2012, 10(9): 966-969.
[3] Liang-ping Hu, Xiao-lei Bao, Chen-yi Guo . Two-factor designs unable to examine the interactions (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(8): 853-857.
[4] Yong Zhang, Xiao-wen Sun, Jian-hua Xu, Hai Lu, Zhong-ze Fan, Jue Sun, Xiao-xiao Zhang. Effects of medicated serum prepared with Chinese herbal medicine Changweiqing on pharmacokinetics of oxaliplatin in colon cancer cells. Journal of Chinese Integrative Medicine, 2012, 10(8): 901-910.
[5] Liang-ping Hu , Xiao-lei Bao, Chen-long Lü . How to choose an appropriate experimental design type (Part 2). Journal of Chinese Integrative Medicine, 2012, 10(7): 738-742.
[6] Liang-ping Hu, Xiao-lei Bao. How to choose an appropriate experimental design type (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(6): 615-618.
[7] Xiao-feng Li, Yong-jun Wang, Xiu-lan Ye, Chong-jian Zhou . Professor Shi Qi’s experience of applying herbal paste for treating chronic musculoskeletal conditions. Journal of Chinese Integrative Medicine, 2012, 10(6): 701-706.
[8] Liang-ping Hu, Xiao-lei Bao, Qi Wang . The balance principle in scientific research. Journal of Chinese Integrative Medicine, 2012, 10(5): 504-507.
[9] Liang-ping Hu, Xiao-lei Bao, Xue Guan . Estimation of sample size and testing power (Part 7). Journal of Chinese Integrative Medicine, 2012, 10(4): 380-383.
[10] Hu Liang-ping, Bao Xiao-lei, Guan Xue, Zhou Shi-guo. Estimation of sample size and testing power (Part 6). Journal of Chinese Integrative Medicine, 2012, 10(3): 298-302.
[11] Hu Liang-ping, Bao Xiao-lei, Guan Xue, Zhou Shi-guo. Estimation of sample size and testing power (Part 5). Journal of Chinese Integrative Medicine, 2012, 10(2): 154-159.
[12] Xiao-lei Bao, Liang-ping Hu. Multifactor designs able to examine the interactions. Journal of Chinese Integrative Medicine, 2012, 10(12): 1371-1374.
[13] Yan-qin Bian, Bing-bing Ning , Hong-yan Cao , Yan LU , Cheng Liu , Gao-feng Chen , Jia Liu , Ping Liu, Ming-yu Sun. Formula-syndrome correlation study of three classical anti-jaundice formulas in inhibition of liver fibrosis induced by dimethylnitrosamine in rats. Journal of Chinese Integrative Medicine, 2012, 10(12): 1405-1412.
[14] Liang-ping Hu, Xiao-lei Bao. Three-factor designs unable to examine the interactions (Part 2). Journal of Chinese Integrative Medicine, 2012, 10(11): 1229-1232.
[15] Liang-ping Hu, Xiao-lei Bao. Three-factor designs unable to examine the interactions (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(10): 1088-1091.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[3] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[4] A-gao Zhou, Yong Zhang, Gang Kui, De-Yun Kong, Hai-liang Ge, Qiu-hua Ren, Jia-rong Dong, Sheng Hong, Xu-ming Mao, Yin Wang, Hui-zheng Zhang, Shu-jun Wang. Influence of traditional Chinese compound recipes with different efficacy on body weight, tumor weight and immune function in H22 cancer-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 77-82
[5] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. Guiding principles of clinical research on mild cognitive impairment (protocol). Journal of Chinese Integrative Medicine, 2008, 6(1): 9-14
[6] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022
[7] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035
[8] Bing Hu , Hong-mei An , Ke-ping Shen , Qin Du. Senescence-inducing effects of Chinese herbal medicine Tenglong Buzhong Decoction on human colon carcinoma LS-174-T cells and the mechanism. Journal of Chinese Integrative Medicine, 2010, 8(11): 1048-1052
[9] Ya-bing Zhou, Jian-er Yu, Jie Wu, Li Bai, Li-li Huo, Xin-guang Zhang, Li-qing Li . Effects of Chinese herbal medicine Bushen Gubiao Recipe on toll-like receptor 4 and CD4 +CD25 +foxp3 +regulatory T cells in mice with recurrent respiratory tract infections. Journal of Chinese Integrative Medicine, 2010, 8(11): 1053-1059
[10] Tao Wang , Feng Qin. Effects of Chinese herbal medicine Xiaoyao Powder on monoamine neurotransmitters in hippocampus of rats with postpartum depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1075-1079