SUBSCRIBE
Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (12): 1190-1194.doi: 10.3736/jcim20101212

• Literature Research • Previous Articles     Next Articles

Functional targets of Chinese herbal medicine

Bin Xiao,Yun Wang   

  1. Information Engineering Center of Traditional Chinese Herbal Medicine,Beijing University of Chinese Medicine, Beijing 100102, China
  • Received:2010-04-16 Accepted:2010-05-07 Online:2010-12-20 Published:2010-12-15
  • Contact: Yun Wang E-mail:wangyun@bucm.edu.cn

RichHTML

2

PDF (PC)

88

Like

In order to elucidate the mechanisms of Chinese herbal medicine, much work has been done based on chemical constituent-target in the molecular system. It cannot comply with the holistic efficacy of Chinese herbal medicine. Thus, the authors of this paper proposed to study the functional target adopted from Western medicine. The data of Chinese herbal function were collected from 2005 edition of The People’s Republic of China Pharmacopoeia. A total of 135 functional targets were found, and a network about functional target and mode of action was built. The authors also explored the applications of functional target and the network combined with Sijunzi Decoction and Mahuang Decoction. The results, reflecting the feature of Chinese herbal medicine, will not only be helpful to elucidate the holistic mechanisms of Chinese herbal medicine, but also beneficial to studying the theory of Chinese formulas and developing new formulas.

Key words: Chinese herbal medicine, Functional target, Mechanisms

"

编号 功能靶点 出现次数 编号 功能靶点 出现次数 编号 功能靶点 出现次数
1 血 173 46 表 13 91 心火 2
2 热 155 47 脓 13 92 胸 2
3 毒 110 48 窍 12 93 阳气 2
4 湿 107 49 痉 11 94 瘀血 2
5 气 104 50 乳 11 95 元气 2
6 痛 104 51 郁 11 96 智 2
7 风 102 52 疹 11 97 崩 1
8 痰 72 53 逆 10 98 表里 1
9 肝 67 54 呕 10 99 冲 1
10 肿 67 55 汗 9 100 冲任 1
11 肾 57 56 坚 9 101 疮毒 1
12 肺 49 57 疟 9 102 带浊 1
13 尿 48 58 胎 9 103 胆火 1
14 瘀 40 59 翳 8 104 呃 1
15 经 37 60 脉 8 105 耳 1
16 结 35 61 暑 8 106 腐 1
17 水 33 62 痒 8 107 肝火 1
18 中 32 63 痈 8 108 肝热 1
19 阳 31 64 烦 7 109 宫 1
20 肠 29 65 肾阳 7 110 蛔 1
21 脾 29 66 滞 7 111 秽 1
22 神 29 67 痹 6 112 惊搐 1
23 虫 28 68 骨蒸 6 113 漏 1
24 胃 28 69 痢 6 114 满 1
25 寒 27 70 饮 6 115 脑 1
26 咳 26 71 关节 6 116 疱 1
27 络 26 72 精血 5 117 清阳 1
28 津 25 73 带 4 118 热毒 1
29 巨 24 74 胆 4 119 伤 1
30 阴 24 75 发 4 120 酸 1
31 便 23 76 筋 4 121 髓 1
32 火 23 77 痞 4 122 唾 1
33 喘 21 78 癥 4 123 涎 1
34 精 21 79 浊 4 124 心肾 1
35 心 21 80 斑 3 125 虚 1
36 疮 20 81 鼻窍 3 126 虚热 1
37 泻 18 82 风痰 3 127 癖 1
38 积 17 83 骨 3 128 炎 1
39 筋骨 17 84 脱 3 129 腰膝 1
40 惊 17 85 胀 3 130 遗 1
41 肌 15 86 疳热 2 131 郁热 1
42 淋 15 87 黄 2 132 折伤 1
43 咽 15 88 渴 2 133 痔 1
44 食 14 89 头目 2 134 赘疣 1
45 燥 14 90 下 2 135 目翳 1

"

"

[1] Li RM . Simple analysis of perplexity of modern research of Chinese medicine, inquiry of foothold,starting point, the key point and breakthrough of modern research of Chinese medicine. Yi Xue Yu Zhe Xue. 2008; 29(12):65-67. Chinese with abstract in English.
李睿明 . 浅析中药现代研究的困惑,探究研究策略.医学与哲学. 2008; 29(12):65-67.
[2] Hou TJ, Qiao XB, Xu XJ . Research and development of 3D molecular structure database of traditional Chinese drugs. Hua Xue Xue Bao. 2001; 59(10):1788-1792. Chinese with abstract in English.
侯廷军, 乔学斌, 徐筱杰 . 中药有效成分三维结构数据库的开发和研究.化学学报. 2001; 59(10):1788-1792.
[3] Wan RF, Xu WY . Discussion on the status quo and the developmental tendency of TCM databases. Zhongguo Yao Fang. 2006; 17(10):794-796. Chinese with abstract in English.
万仁甫, 徐伟亚 . 中药数据库的现状及发展趋势探讨. 中国药房. 2006; 17(10):794-796.
[4] Wu DH, Xu XJ . Computational simulation of benefiting qi and activating blood mechanism of traditional Chinese medicine. Wu Li Hua Xue Xue Bao. 2009; 25(3):446-450. Chinese with abstract in English.
doi: 10.3866/PKU.WHXB20090309
吴钉红, 徐筱杰 . 中药补气与活血分子作用机制的计算机模拟.物理化学学报. 2009; 25(3):446-450.
doi: 10.3866/PKU.WHXB20090309
[5] Ehrman TM, Barlow DJ, Hylands PJ . Virtual screening of Chinese herbs with Random Forest.[J] Chem Inf Model. 2007; 47(2) : 264-278.
doi: 10.1021/ci600289v
[6] Wang Y, Zhang YL, Shi XY, Qiao YJ.Construction and application of TCM function networks. Shi Jie Ke Xue Ji Shu Zhong Yi Yao Xian Dai Hua. 2008; 10(5):105-108. Chinese with abstract in English.
王耘, 张燕玲, 史新元, 乔延江 . 中药功效网络的构建及应用.世界科学技术:中医药现代化. 2008; 10(5):105-108.
[7] Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T . Cyto- scape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003; 13(11) : 2498-2504.
doi: 10.1101/gr.1239303
[8] Xing YR. Basic theory of traditional Chinese medicine. Xi5an: Shaanxi Science and Technology Press. 2005: 7-331. Chinese.
刑玉瑞 . 中医基础理论.西安: 陕西科学技术出版社. 2005: 7-331.
[9] Xu JQ. Formulas of traditional Chinese medicine. Shanghai: Shanghai Scientific and Technical Publishers. 2006: 93-94. Chinese.
许济群.方剂学 .上海: 上海科学技术出版社. 2006: 93-94.
[10] Wang XH . Basic theory of traditional Chinese medicine. Beijing: People’s Medical Publishing House. 2003: 184-198. Chinese.
王新华 . 中医基础理论.北京: 人民卫生出版社. 2003: 184-198.
[1] Shu-yi Chen, Qun-wei Chen, Liu-mei Shou, Hong Pan, Shan-ming Ruan, Zhe-hao Liang, Qi-jin Shu. Stevens-Johnson syndrome/toxic epidermal necrolysis successfully treated with Chinese herbal medicine Pi-Yan-Ning: A case report. Journal of Integrative Medicine, 2021, 19(6): 555-560.
[2] Xin Yin, Shu-bin Cai, Lan-ting Tao, Lu-ming Chen, Zhong-de Zhang, Su-hong Xiao, Arthur Yin Fan, Xu Zou. Recovery of a patient with severe COVID-19 by acupuncture and Chinese herbal medicine adjuvant to standard care. Journal of Integrative Medicine, 2021, 19(5): 460-466.
[3] Qing-lan Wang, Yan-yan Tao, Hong-dong Xie, Cheng-hai Liu, Ping Liu. Fuzheng Huayu recipe, a traditional Chinese compound herbal medicine, attenuates renal interstitial fibrosis via targeting the miR-21/PTEN/AKT axis. Journal of Integrative Medicine, 2020, 18(6): 505-513.
[4] Ming-sheng Lyu, De-ying Li, Shao-zhong Zhou, Cheng-jun Ban, Jun Yan. Adult-onset Still's disease successfully treated with Chinese herbal medicine: A case report with 15-month follow-up. Journal of Integrative Medicine, 2020, 18(6): 530-534.
[5] Mu-yan Kong, Le-yan Li, Yan-mei Lou, Hong-yu Chi, Jin-jun Wu. Chinese herbal medicines for prevention and treatment of colorectal cancer: from molecular mechanisms to potential clinical applications. Journal of Integrative Medicine, 2020, 18(5): 369-384.
[6] Arthur Yin Fan, Sherman Gu, Sarah Faggert Alemi, Research Group for Evidence-based Chinese Medicine. Chinese herbal medicine for COVID-19: Current evidence with systematic review and meta-analysis. Journal of Integrative Medicine, 2020, 18(5): 385-394.
[7] Bin Lan, Jin-wen Ge, Shao-wu Cheng, Xi-long Zheng, Jun Liao, Chao He, Zheng-qing Rao, Guo-zuo Wang. Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats. Journal of Integrative Medicine, 2020, 18(4): 344-350.
[8] Eric Wei Chiang Chan, Siu Kuin Wong, Hung Tuck Chan . Casticin from Vitex species: A short review on its anticancer and anti-inflammatory properties. Journal of Integrative Medicine, 2018, 16(3): 147-152.
[9] Tom Fleischer, Tung-Ti Chang, Hung-Rong Yen. Post-hematopoietic stem cell transplantation in patients with hematologic disorders: Chinese herbal medicine for an unmet need. Journal of Integrative Medicine, 2016, 14(5): 322-335.
[10] Wei Chiang Chan Eric, Kuin Wong Siu. Phytochemistry and pharmacology of ornamental gingers, Hedychium coronarium and Alpinia purpurata: A review. Journal of Integrative Medicine, 2015, 13(6): 368-379.
[11] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228.
[12] Bin Xiao, Ou Tao, Ji Luo, Yun Wang. Relationships between properties and functional targets of Chinese herbs. Journal of Chinese Integrative Medicine, 2011, 9(7): 789-793.
[13] Xiao Bin, Tao Ou, Gu Hao, Wang Yun, Qiao Yan-jiang. Standardization of the terms for Chinese herbal functions based on functional targeting. Journal of Chinese Integrative Medicine, 2011, 9(3): 252-256.
[14] Yan-li Zhang, Li-ping Qin, Kai-li Wang, Bai Li. Protective effects of Chinese herbal medicine Huqi extractum on salivary glands against radiation in Wistar rats. Journal of Chinese Integrative Medicine, 2011, 9(1): 70-76.
[15] L Liu, XQ Yue, LN Wang, W Gu, HL Xin, GY Zheng, CQ Ling. Preventive effects of a sachet of Chinese herbs on influenza and its immune regulation. Journal of Chinese Integrative Medicine, 2010, 8(10): 949-954.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[2] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[3] Xi Lin, Jian-ping Liu. Herbal medicines for viral myocarditis. Journal of Chinese Integrative Medicine, 2008, 6(1): 76
[4] Xi Lin, Jian-ping Liu. Tai chi for treating rheumatoid arthritis. Journal of Chinese Integrative Medicine, 2008, 6(1): 82
[5] Liang-ping Hu, Hui Gao. Discrimination of errors in statistical analysis of medical papers published in the first issue of 2006 in Journal of Chinese Integrative Medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 98-106
[6] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035
[7] Wei Xu, Meng Shi, Jian-gang Liu, Cheng-long Wang . Collagen protein expressions in ischemic myocardium of rats with acute myocardial infarction and effects of qi-tonifying, yin-tonifying and blood-activating herbs and detoxifying and blood-activating herbs. Journal of Chinese Integrative Medicine, 2010, 8(11): 1041-1047
[8] Tao Wang , Feng Qin. Effects of Chinese herbal medicine Xiaoyao Powder on monoamine neurotransmitters in hippocampus of rats with postpartum depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1075-1079
[9] Ying Xu , Chang-chun Zeng , Xiu-yu Cai , Rong-ping Guo , Guang Nie , Ying Jin. Chromaticity and optical spectrum colorimetry of the tongue color in different syndromes of primary hepatic carcinoma. Journal of Chinese Integrative Medicine, 2012, 10(11): 1263-1271
[10] Xiang-ying Mao , Qin Bian , Zi-yin Shen. Analysis of the osteogenetic effects exerted on mesenchymal stem cell strain C3H10T1/2 by icariin via MAPK signaling pathway in vitro. Journal of Chinese Integrative Medicine, 2012, 10(11): 1272-1278
Journal of Integrative Medicine, ISSN: 2095-4964 CN 31-2083/R
Copyright © Journal of Integrative Medicine
Powered by Beijing Magtech Co. Ltd
沪公网安备31010602003416号      沪ICP备18017633号-3