扶正抑瘤颗粒对放疗食管癌患者癌组织中CD44v6与nm23-H1表达的影响

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Effects of Fuzheng Yiliu Granule on expression of CD44v6 and nm23-H1 in esophageal carcinoma treated with radiotherapy

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doi:10.3736/jcim20040406

Objective: To evaluate the effects of Fuzheng Yiliu Granule on the expression of CD44v6 and nm23-H1 in esophageal carcinoma treated with radiotherapy.Methods: Sixty-three cases of esophageal carcinoma were randomly divided into two groups: Fuzheng Yiliu Granule plus radiotherapy treated group (n=30) and radiotherapy treated group (n=33). The carcinoma specimens were obtained through endoscopic biopsy before and after twenty-one days of treatment. The expression of CD44v6 and nm23-H1 was determined in the sixty-three specimens of esophageal carcinoma by immunohistochemical SABC methods.Results: After twenty-one days of treatment, the positive rates of CD44v6 in the Fuzheng Yiliu Granule plus radiotherapy treated group and the radiotherapy treated group were 40.0% and 69.7%, respectively, and there was significant difference between the two groups (P<0.05). The positive rates of nm23-H1 in the Fuzheng Yiliu Granule plus radiotherapy treated group and the radiotherapy treated group were 20.0% and 21.2%, respectively, and the difference was not significant between the two groups (P>0.05).Conclusio: Fuzheng Yiliu Granule can lower the expression of CD44v6 in esophageal carcinoma, and may prevent infiltration and lymph node metastasis of esophageal carcinoma.

Key words: Fuzheng Yiliu Granule, esophageal carcinoma, CD44v6, nm23-H1

CLC Number:

R289.5

Jian-xiong Zhao, Xue-feng Li. Effects of Fuzheng Yiliu Granule on expression of CD44v6 and nm23-H1 in esophageal carcinoma treated with radiotherapy. Journal of Chinese Integrative Medicine, 2004, 2(4): 262-264.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20040406

http://www.jcimjournal.com/EN/Y2004/V2/I4/262

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Group	n	CD44v6		nm23-H1
Group	n	Positive	Negative	Positive	Negative
Fuzheng Yiliu Granule plus radiotherapy treated group
Before treatment	30	21(70.00)	9 (30.00)	4(13.33)	26 (86.67)
After treatment	30	12(40.00) *	18 (60.00)	6(20.00)	24 (80.00)
Radiotherapy treated group
Before treatment	33	23(69.70)	10 (30.30)	6(18.18)	27 (81.82)
After treatment	33	23(69.70)	10 (30.30)	7(21.21)	26 (78.79)

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