活血通脉利水明目法治疗非缺血型视网膜静脉阻塞的随机对照试验:对眼底荧光血管造影结果的影响

doi:10.3736/jcim20091103

Abstract

Background

Huoxue Tongmai Lishui method, a traditional Chinese medicine treatment for eliminating water, activating and promoting blood circulation, could inhibit fundus hemorrhage on experimental retinal vein occlusion (RVO) with high obvious effective rate, and improve symptoms in traditional Chinese medicine. The action mechanism may be related to reducing plasma viscosity and non-perfusion area, and the formation of collateral circulation.
Objective

To explore the therapeutic effects of Huoxue Tongmai Lishui method (Sanxue Mingmu Tablet) on fundus fluorescent angiograph of non-ischemic retinal vein occlusion (RVO).Design, setting, participants and interventions: Thirty-four patients with non-ischemic RVO in Department of Ophthalmology, the First Affiliated Hospital, Hunan University of Traditional Chinese Medicine from April 2005 to April 2009 were included. All the patients were diagnosed as qi stagnation and blood stasis syndrome or hyperactivity of liver yang syndrome, and they were randomly divided into two groups, with 17 eyes of 17 patients in treatment group treated by Sanxue Mingmu Tablet combined with conventional treatment, and 18 eyes of 17 patients in control group treated by Xueshuantong Tablet combined with conventional treatment. The patients were treated for two months.Main outcome measures: Fundus colour photography, and fundus fluorescent angiograph were detected in two groups before and after the treatment.
Results

The curative effect of Sanxue Mingmu Tablet was better than that of Xueshuantong Tablet. Huoxue Tongmai Lishui method could significantly shorten the retinal circulation time, reduce the non-perfusion area, decrease the formation of angiogenesis and promote the formation of collateral circulation.
Conclusion

Huoxue Tongmai Lishui method is an effective traditional Chinese medicine treatment with high obvious effective rate in reducing non-perfusion area and avoiding venous occlusion and formation of collateral circulation.

Key words: Sanxue Mingmu Tablet, Retinal vein occlusion, Fundus fluorescence photography, Randomized controlled trial

Qing-hua Peng, Xiao-lei Yao, Zhi-cheng Zeng, Rui-bing Su, Yan-ping Wei. Effects of Huoxue Tongmai Lishui method on fundus fluorescein angiography of non-ischemic retinal vein occlusion: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2009, 7(11): 1035-1041.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20091103

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References 15

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Item	Control group (n=17)		Treatment group (n=17)
Item	Before treatment	After treatment	Before treatment	After treatment
Light perception (Eyes)	0	0	0	0
Finger count/30 cm (Eyes)	0	1	0	0
Standard visual acuity
0.01–0.09 (Eyes)	1	2	1	0
0.1–0.3 (Eyes)	9	6	9	0
0.4–0.6 (Eyes)	7	5	6	7
0.7–0.9 (Eyes)	1	4	1	7
1.0–1.5 (Eyes)	0	0	0	3
Log MAR ($\bar{x}$±s)	1.470±0.189	1.464±0.299	1.325±0.174	0.332±0.089

Group	n	Number of eyes of different retinal circulation time
Group	n	1–1.9 s	2–3.9 s	4–5.9 s	6–7.9 s	8–9.9 s
Control
Before treatment	17	0	5	7	6	0
After treatment	17	1	7	6	4	0
Treatment
Before treatment	17	0	5	6	5	1
After treatment	17	3	8	4	2	0

Effects of Huoxue Tongmai Lishui method on fundus fluorescein angiography of non-ischemic retinal vein occlusion: A randomized controlled trial

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