Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (6): 509-513.doi: 10.3736/jcim20090603

• Original Clinical Research • Previous Articles     Next Articles

Effects of Songling Xuemaikang Capsule on ambulatory blood pressure in treatment of essential hypertension: A single-blind randomized controlled trial

 Li Fu,Zhen-xing Mao, Jing Wang, Jing Zhang, Tai-rong Zheng, Sheng-lian Wang   

  1. Department of Cardiology, Chengdu First Peopled Hospital, Chengdu 610041, Sichuan Province, China
  • Received:2008-12-08 Accepted:2009-02-19 Online:2009-06-20 Published:2009-06-15


To explore the effects of Western medicine including Ca 2+ channel antagonist and angiotensin-receptor antagonist combined with Songling Xuemaikang Capsule (SXC), a compound traditional Chinese herbal medicine for calming liver and suppressing liver yang, on blood pressure indexes derived from 24-hour ambulatory blood pressure monitoring (ABPM), and to evaluate the effects and stability of SXC in lowering blood pressure.

Seventy patients with essential hypertension of grade 2 or grade 3 were randomly assigned to routine group and SXC group. There were 35 cases in each group. The patients in the routine group were administered with 2.5 mg levoamlodipine and 40 mg telmisartan once daily, and 1.5 g SXC was administered orally to the patients in the SXC group three times daily besides levoamlodipine and telmisartan treatment. They were all treated for two weeks. Twenty-four-hour ABPM, trough to peak ratio and smoothness index were measured before and after the treatment.

Twenty-four-hour, day and night average systolic blood pressure (SBP) and 24-hour, day and night SBP load in the two groups were lowered as compared with before treatment (P<0.05). The effects of Western medicine combined with SXC on blood pressure depression were better than those of Western medicine (P<0.05). Western medicine combined with SXC had a significant influence on diastolic blood pressure (DBP) as compared with Western medicine (P<0.05). The heart rate in the SXC group was reduced as compared with before treatment and the routine group (P<0.05). Trough to peak ratio in SXC group was higher than that in the routine group, while there was no significant difference in smoothness index between the two groups. Morning surge in blood pressure in the two groups was improved as compared with before treatment (P<0.05), and there was a significant difference in morning surge in blood pressure between the two groups (P<0.05).

Western medicine combined with SXC has long-lasting effects in lowering heart rate and blood pressure, especially for SBP and SBP load. SXC plus Western medicine also has an inhibition effect on morning surge in blood pressure.

Key words: Hypertension, Blood pressure determination, Randomized controlled trial, Single-blind method

Table 1

Changes of ambulatory blood pressure in two groups (x±s, mmHg)"

Group n Twenty-four-hour
average SBP
average DBP
average SBP
average DBP
average SBP
average DBP
Before treatment 35 138.0±12.6 89.0±10.6 145.0±10.6 90.0±12.4 128.0±10.0 86.0±9.7
After treatment 35 119.0±8.5* 84.0±9.8 129.0±12.1* 88.0±10.3 110.0±10.6* 79.0±9.8*
Before treatment 35 145.0±12.3 88.0±11.1 147.0±11.4 91.0±9.9 132.0±11.1 84.0±11.4
After treatment 35 118.0±13.2* 77.0±8.4* 120.0±8.9* 83.0±11.4* 108.0±8.3* 73.0±8.8*

Table 2

Blood pressure load in two groups"

Group n Day SBP load
[M (Q25, Q75), %]
Day DBP load
[M (Q25, Q75),%]
Night SBP load
[M (Q25, Q75),%]
Night DBP load
(x±s, %)
Before treatment 35 70 (54,100) 58 (49,87) 70 (40,92) 50.2±13.7
After treatment 35 36 (20,70)* 45 (30,80) 39 (15, 68)* 33.5±11.3*
Before treatment 35 75 (52,100) 55 (21,71) 74 (32,88) 44.1±18.5
After treatment 35 15 (5,52)*△ 24 (7,49)* 20 (9,48)* 23.6±13.9*
[1] The Revising Committee of Chinese Guidelines for Hypertension Prevention and Treatment. A revised version(2005) of Chinese guidelines for hypertension prevention and treatment[J]. Gao Xue Ya Za Zhi, 2005,13(Suppl):241
中国高血压防治指南修订委员会. 中国高血压防治指南(2005年修订版)[J]. 高血压杂志, 2005,13(Suppl):241
[2] Lin BX, Guo JZ, Zhang BH, Zhu JR . Study on methodology of calculating trough to peak ratio according to ambulatory blood pressure monitoring[J]. Zhonghua Xin Xue Guan Bing Za Zhi, 2004,32(4):313-316
林伯贤, 郭冀珍, 张博恒, 诸骏仁 . 用动态血压监测探讨计算T/P比值方法学研究[J]. 中华心血管病杂志, 2004,32(4):313-316
[3] Morgan T, Menard J, Brunnar H . Trough to peak ratio as a guide to BP control: measurement and calculation[J]. J Hum Hypertens, 1998,12(1):49-53
doi: 10.1038/sj.jhh.1000536
[4] Huang QF, Li Y, Wang JG . Morning surge in blood pressure[J]. Zhonghua Xin Xue Guan Bing Za Zhi, 2008,36(1):91-93
黄绮芳, 李燕, 王继光 . 血压晨峰[J]. 中华心血管病杂志, 2008,36(1):91-93
[5] Kario K, Pickering TG, Umeda Y, Hoshide S, Hoshide Y, Morinari M, Murata M, Kuroda T, Schwartz JE, Shimada K . Morning surge in blood pressure as a prediction of silent and clinical cerebrovascular disease in elderly hypertensives: a prospective study[J]. Circulation, 2003,107(10):1401-1406
doi: 10.1161/01.CIR.0000056521.67546.AA
[6] Hua Q, Liu DX. Recommendations on updating blood pressure measurement from the American Heart Association and the concepts of hypertension. In: Hu DY, Ma CS. Cardiology practice 2005 — new progress and case report. Beijing: People’s Medical Publishing House. 2005: 201-213. Chinese.
华琦, 刘东霞 . 美国心脏协会更新血压测量方法建议的介绍及高血压相关概念. 见: 胡大一, 马长生. 心脏病学实践2005——新进展与临床案例. 北京: 人民卫生出版社. 2005: 201-213.
[7] Meredith PA . Role of trough to peak efficacy in the evaluation of antihypertensive therapy[J]. J Hypertens, 1998,16(1):59-64
[8] Qi WH . Advances in research into hypertension[J]. Xin Xue Guan Bing Xue Jin Zhan, 2006,27(5):538-542
戚文航 . 高血压领域研究进展[J]. 心血管病学进展, 2006,27(5):538-542
[9] Hua Q, Pi L, Li DB, Liu LS, Liu RK . Influence of circadian rhythm on cardiac structure and function in patients with essential hypertension[J]. Zhonghua Xin Xue Guan Bing Za Zhi, 2003,31(8):594-596
华琦, 皮林, 李东宝, 刘力松, 刘荣坤 . 高血压患者昼夜节律对心脏结构和功能的影响[J]. 中华心血管病杂志, 2003,31(8):594-596
[1] Chiung-Hui Huang, Mei-Ling Yeh, Fang-Pey Chen, Daphne Wu. Low-level laser acupuncture reduces postoperative pain and morphine consumption in older patients with total knee arthroplasty: A randomized placebo-controlled trial. Journal of Integrative Medicine, 2022, 20(4): 321-328.
[2] Maryam Azimi, Hanieh Niayesh, Mahboobeh Raeiszadeh, Sedigheh Khodabandeh-shahraki. Efficacy of the herbal formula of Foeniculum vulgare and Rosa damascena on elderly patients with functional constipation: A double-blind randomized controlled tria. Journal of Integrative Medicine, 2022, 20(3): 230-236.
[3] Ubiratan Cardinalli Adler, Maristela Schiabel Adler, Ana Elisa Madureira Padula, Livia Mitchiguian Hotta, Amarilysde Toledo Cesar, José Nelson Martins Diniz, Helen de Freitas Santos, Edson Zangiacomi Martinez. Homeopathy for COVID-19 in primary care: A randomized, double-blind, placebo-controlled trial (COVID-Simile study). Journal of Integrative Medicine, 2022, 20(3): 221-229.
[4] Xin Wang, Wen-juan Song, Yi Ruan, Bing-chu Li, Can Lü, Nian Huang, Fan-fu Fang, Wei Gu. Core muscle functional strength training for reducing the risk of low-back pain in military recruits: An open-label randomized controlled trial. Journal of Integrative Medicine, 2022, 20(2): 145-152.
[5] Shuai Chen, Jin Hu, Deng-cheng Lu, Hong-yi Liu, Shan-shan Wei. Metabolomic characteristics of spontaneously hypertensive rats under chronic stress and the treatment effect of Danzhi Xiaoyao Powder, a traditional Chinese medicine formula. Journal of Integrative Medicine, 2022, 20(1): 73-82.
[6] Rakhi Chakraborty, Swarnendu Roy. Angiotensin-converting enzyme inhibitors from plants: A review of their diversity, modes of action, prospects, and concerns in the management of diabetes-centric complications. Journal of Integrative Medicine, 2021, 19(6): 478-492.
[7] Meng-zhu Zhao, Chen Zhao, Shuang-shuang Tu, Xu-xu Wei, Hong-cai Shang. Evaluating the methodology of studies conducted during the global COVID-19 pandemic: A systematic review of randomized controlled trials. Journal of Integrative Medicine, 2021, 19(4): 317-326.
[8] Si-chun Gu, Jie Zhou, Qing Ye, Can-xing Yuan. Pingchan granule for depressive symptoms in Parkinson’s disease: A randomized, double-blind, placebo-controlled trial. Journal of Integrative Medicine, 2021, 19(2): 120-128.
[9] Jie Wu, Shu-wei Duan, Hong-tao Yang, Yue-yi Deng, Wei Li, Ya-ni He, Zhao-hui Ni, Yong-li Zhan, Shan Lin, Zhi-yong Guo, Jun Zhu, Jing-ai Fang, Xu-sheng Liu, Li-hua Wang, Rong Wang, Nian-song Wang, Xiao-hong Cheng, Li-qun He, Ping Luo, Shi-ren Sun s, Ji-feng Sun, Ai-ping Yin, Geng-ru Jiang, Hong-yu Chen, Wen-hu Liu, Hong-li Lin, Meng Liang, Lu Ma, Ming Chen, Li-qun Song, Jian Chen, Qing Zhu, Chang-ying Xing, Yun Li, Ji-ning Gao, Rong-shan Li, Ying Li, Hao Zhang, Ying Lu, Qiao-ling Zhou, Jun-zhou Fu, Qiang He, Guang-yan Cai, Xiang-mei Chen. Efficacy and safety of Shenyankangfu Tablet, a Chinese patent medicine, for primary glomerulonephritis: A multicenter randomized controlled trial. Journal of Integrative Medicine, 2021, 19(2): 111-119.
[10] Xian Wang, Xuan Yin, Xiu-tian Guo, Yan Wang, Wen-qi Jin, Ai-jun Mao, Lixing Lao, Zhang-jin Zhang, Jie Zhang, Shi-fen Xu. Effects of the pestle needle therapy, a type of acupoint stimulation, on post-hemorrhoidectomy pain: A randomized controlled trial. Journal of Integrative Medicine, 2020, 18(6): 492-498.
[11] Sherman Gu, Arthur Yin Fan. Controversial conclusions from two randomized controlled trials for acupuncture's effects on polycystic ovary syndrome or in vitro fertilization support. Journal of Integrative Medicine, 2020, 18(2): 89-91.
[12] Gerli E.G. Herr, Fábio Goulart da Silva, Francisco José Cidral-Filho, Fabricia Petronilho, Lucinéia Gainski Danielski, Mariana Pereira de Souza Goldim, Afonso Shiguemi Inoue Salgado, Franciane Bobinski, Daniel Fernandes Martins, Eliane R. Winkelmann. Effects of the use of bioceramic wraps in patients with lower limb venous ulcers: A randomized double-blind placebo-controlled trial. Journal of Integrative Medicine, 2020, 18(1): 27-.
[13] Pranay Soni, Rajesh Choudhary, Surendra H. Bodakhe. Effects of a novel isoflavonoid from the stem bark of Alstonia scholaris against fructose-induced experimental cataract. Journal of Integrative Medicine, 2019, 17(5): 374-382.
[14] Xin-yu Yue, Zhuo-qi Feng, Xi-yi Yu, Jia-min Hu, Xiao-Jing He, Shi Shu. Fire-needle acupuncture for upper limb spastic paralysis after stroke: Study protocol for a randomized controlled trial. Journal of Integrative Medicine, 2019, 17(3): 167-172.
[15] Pádraic J.Dunne, Julie Lynch, Lucia Prihodova, Caoimhe O'Leary, Atiyeh Ghoreyshi, Sharee A. Basdeo, Donal J.Cox, Rachel Breen, Ali Sheikhi, Áine Carroll, Cathal Walsh, Geraldine McMahon, Barry White. Burnout in the emergency department: Randomized controlled trial of an attention-based training program. Journal of Integrative Medicine, 2019, 17(3): 173-180.
Full text



[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228