SUBSCRIBE
Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (1): 25-29.doi: 10.3736/jcim20100105

• Original Clinical Research • Previous Articles     Next Articles

Prevention of hospital-acquired pneumonia with Yupingfeng Powder in patients with acute cerebral vascular diseases: A randomized controlled trial

 Li Yana, Xian-chuan Chenb, Jian Guoa, Li-li Qia, Yi-ming Qiana, Xiong-gen Zhoua   

  1. a Department of Emergency, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
    b Department of Geriatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
  • Received:2009-07-13 Accepted:2009-10-14 Online:2010-01-20 Published:2010-01-15
  • Contact: Li Yan E-mail:yanli1137@163.com

RichHTML

3

PDF (PC)

50

Like

Background

An increase in the incidence rate of hospital-acquired pneumonia (HAP) has a direct influence on prognosis and survival of patients with acute cerebral vascular diseases (ACVD), and how to prevent HAP is a growing concern to clinicians.
Objective

To study the efficacy of Yupingfeng Powder, a compound traditional Chinese herbal medicine, in preventing HAP in patients with ACVD.
Design, setting, participants and interventions

Sixty ACVD patients with lung qi deficiency syndrome without concurrent infections were randomly divided into prevention group (28 cases) and control group (32 cases). The 60 cases were all from Shanghai Yueyang Hospital of Integrated Traditional Chinese and Western Medicine. Tough measures were taken to prevent cross-infection based on treatment of the primary diseases, well nutrition and support therapy. Yupingfeng Powder was used in the prevention group to prevent HAP. The patients were treated for 10 days.
Main outcome measures

The clinical symptoms, physical signs, body temperature, and chest X-ray were observed. The changes of blood immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM) and interleukin-6 (IL-6) were detected before and after treatment.
Results

The total response rate in the prevention group was higher than that in the control group (P<0.05), and the total response rates were 78.57% (22/28) and 31.25% (10/32) respectively. The incidence rate of HAP in the prevention group was lower than that in the control group. There were no significant differences in white blood cell count, neutrophilic granulocyte count, and the levels of IgA, IgG, IgM and IL-6 between the two groups before treatment. The white blood cell count and neutrophilic granulocyte count in the control group increased after treatment, and there was a significant difference between the two groups (P<0.05). There was no significant difference in IgA level in the two groups after treatment, and the IgM levels in the two groups were higher than those before treatment (P<0.05), however there was no significant difference in IgM level between the two groups. In the prevention group, there were significant differences in values of IgG and IL-6 between before and after treatmant (P<0.01), and after treatment there were differences in values of IgG and IL-6 between the two groups (P<0.05).
Conclusion

Yupingfeng Powder has a good clinical effect in prevention of HAP in patients with ACVD, and it can improve the immunological function and relieve the lung qi deficiency symptoms. So the prevention effect of Yupingfeng Powder on HAP is worth being further investigated.

Key words: Brain vascular disorder, Hospital-acquired pneumonia, Prevention, Randomized controlled trial, Chinese herbal drugs

Table 1

General conditions of two groups"

Item Control group
(n=32)		 Prevention group
(n=28)
Mean age (x±s, years) 69.13±8.12 68.86±8.33
Sex (Male/Female) 20/12 18/10
Hypertension 15 12
Coronary heart disease 5 4
Type 2 diabetes 7 6
Chronic obstructive pulmonary disease 1 2
Other diseases 4 4
Ischemic stroke/Cerebral hemorrhagic stroke 30/2 26/2
Oral intake/Nasal feed 27/5 24/4

Figure 1

Flow diagram of this randomized trial"

[1] Society of Respiratory Diseases, Chinese Medical Association . Guidelines for the diagnosis and treatment of hospital-acquired pneumonia(Draft)[J]. Zhonghua Jie He He Hu Xi Za Zhi, 1999,22(4):201
中华医学会呼吸病学分会. 医院获得性肺炎诊断和治疗指南(草案)[J]. 中华结核和呼吸杂志, 1999,22(4):201
[2] Kong FB, Zhao Y, Shao FY, Zhao ZX, Zhang LY . Complications in acute stroke patients[J]. Di Er Jun Yi Da Xue Xue Bao, 2000,21(5):459
doi: 10.3321/j.issn:0258-879X.2000.05.035
孔凡斌, 赵瑛, 邵福源, 赵忠新, 张连运 . 急性脑卒中并发症分析[J]. 第二军医大学学报, 2000,21(5):459
doi: 10.3321/j.issn:0258-879X.2000.05.035
[3] Katzan IL, Cebul RD, Husak SH, Dawson NV, Baker DW . The effect of pneumonia on mortality among patients hospitalized for acute stroke[J]. Neurology, 2003,60(4):620-625
doi: 10.1212/01.WNL.0000046586.38284.60 pmid: 12601102
[4] Davenport RJ, Dennis MS, Wellwood I, Warlow CP . Complications after acute stroke[J]. Stroke, 1996,27(3):415-420
doi: 10.1161/01.STR.27.3.415
[5] Deng BM, Xu E, Liang R, Liu ZY, Lu XF . The effects of medical complications on prognosis of the stroke patients[J]. Zhong Feng Yu Shen Jing Ji Bing Za Zhi, 2005,22(1):59-61
doi: 10.3969/j.issn.1003-2754.2005.01.019
邓兵梅, 徐恩, 梁睿, 刘祖佑, 陆雪芬 . 内科并发症对急性脑卒中患者预后的影响[J]. 中风与神经疾病杂志, 2005,22(1):59-61
doi: 10.3969/j.issn.1003-2754.2005.01.019
[6] Feng T, Wang YJ, Qi XK . The relationship between serum thrombomodulin and tumor necrosis factor-α in acute cerebral infarct with HAP[J]. Zhongguo Dong Mai Ying Hua Za Zhi, 2005,13(6):757-759
doi: 10.3969/j.issn.1007-3949.2005.06.022
冯涛, 王拥军, 戚晓昆 . 脑梗死合并肺部感染后血浆血栓调节蛋白与肿瘤坏死因子α的相关性[J]. 中国动脉硬化杂志, 2005,13(6):757-759
doi: 10.3969/j.issn.1007-3949.2005.06.022
[7] Chinese Society of Neuroscience and Chinese Society of Neurosurgery . The diagnostic outlines for different types of cerebrovascular diseases[J]. Zhonghua Shen Jing Ke Za Zhi, 1996,29(6):379-380
中华神经科学会, 中华神外科学会. 各类脑血管疾病诊断要点[J]. 中华神经科杂志, 1996,29(6):379-380
[8] State Food and Drug Administration. Guidelines for clinical research on Chinese new herbal medicines(trial implementation)[M]. Beijing: Medical Science and Technology Publishing House of China, 2002: 298
国家食品药品监督管理局. 中药新药临床研究指导原则(试行)[M]. 北京: 中国医药科技出版社, 200:298
[9] Hamidon BB, Raymond AA . Risk factors and complications of acute ischaemic stroke patients at Hospital Universiti Kebangsaan Malaysia(HUKM)[J]. Med J Malaysia, 2003,58(4):499-505
[10] Hong K . Diagnosis and treatment of medical complications in acute stroke patients[J]. Yi Xue Zong Shu, 2006,10(6):366-368
doi: 10.3969/j.issn.1006-2084.2004.06.021
洪克 . 急性脑卒中常见并发症的诊治[J]. 医学综述, 2006,10(6):366-368
doi: 10.3969/j.issn.1006-2084.2004.06.021
[11] Wang JF, Zhong LZ, Li P, Xie TG, Li Z . Changes of serum IL-10 and Ag-NORs of T lymphocytes in patients with acute cerebral[J]. strokeShen Jing Ji Bing Yu Jing Shen Wei Sheng, 2006,6(2):98-100
doi: 10.3969/j.issn.1009-6574.2006.02.006
王剑锋, 钟丽珍, 李萍, 谢田刚, 李志 . 脑卒中急性期血清白介素-10和外周血T淋巴细胞Ag-NORs的动态变化[J]. 神经疾病与精神卫生, 2006,6(2):98-100
doi: 10.3969/j.issn.1009-6574.2006.02.006
[12] Li ML, Luo ZM . A research on factors influencing the clinical prognosis of acute stroke patients[J]. Hua Xi Yi Xue, 2001,16(3):289-291
doi: 10.3969/j.issn.1002-0179.2001.03.019
李曼丽, 罗祖明 . 影响脑卒中患者临床预后因素的研究[J]. 华西医学, 2001,16(3):289-291
doi: 10.3969/j.issn.1002-0179.2001.03.019
[13] Chang FY, Wang YY . Review on the pathogenesis of stroke[J]. Liaoning Zhong Yi Za Zhi, 2004,31(2):21-23
常富业, 王永炎 . 中风病发病学研究述评[J]. 辽宁中医杂志, 2004,31(2):21-23
[1] Sherman Gu, Arthur Yin Fan. Controversial conclusions from two randomized controlled trials for acupuncture's effects on polycystic ovary syndrome or in vitro fertilization support. Journal of Integrative Medicine, 2020, 18(2): 89-91.
[2] Gerli E.G. Herr, Fábio Goulart da Silva, Francisco José Cidral-Filho, Fabricia Petronilho, Lucinéia Gainski Danielski, Mariana Pereira de Souza Goldim, Afonso Shiguemi Inoue Salgado, Franciane Bobinski, Daniel Fernandes Martins, Eliane R. Winkelmann. Effects of the use of bioceramic wraps in patients with lower limb venous ulcers: A randomized double-blind placebo-controlled trial. Journal of Integrative Medicine, 2020, 18(1): 27-.
[3] Xin-yu Yue, Zhuo-qi Feng, Xi-yi Yu, Jia-min Hu, Xiao-Jing He, Shi Shu. Fire-needle acupuncture for upper limb spastic paralysis after stroke: Study protocol for a randomized controlled trial. Journal of Integrative Medicine, 2019, 17(3): 167-172.
[4] Ya-ru Huangfu, Wei Peng, Bao-jun Guo, Zhi-fu Shen, Li Li, Shi-wei, Liu, Hui Zheng, You-ping Hu. Effects of acupuncture in treating insomnia due to spleen-stomach disharmony syndrome and its influence on intestinal microbiome: Study protocol for a randomized controlled trial. Journal of Integrative Medicine, 2019, 17(3): 161-167.
[5] Pádraic J.Dunne, Julie Lynch, Lucia Prihodova, Caoimhe O'Leary, Atiyeh Ghoreyshi, Sharee A. Basdeo, Donal J.Cox, Rachel Breen, Ali Sheikhi, Áine Carroll, Cathal Walsh, Geraldine McMahon, Barry White. Burnout in the emergency department: Randomized controlled trial of an attention-based training program. Journal of Integrative Medicine, 2019, 17(3): 173-180.
[6] J.M. Oliver-Baxter, H.S. Whitford, D.A. Turnbull, M.J. Bond. Effects of vitamin supplementation on inflammatory markers and psychological wellbeing among distressed women: A randomized controlled trial. Journal of Integrative Medicine, 2018, 16(5): 322-328.
[7] Parunkul Tungsukruthai, Preecha Nootim, Wiwan Worakunphanich, Nareerat Tabtong. Efficacy and safety of herbal steam bath in allergic rhinitis: A randomized controlled trial. Journal of Integrative Medicine, 2018, 16(1): 39-44.
[8] Zahra Hajmohammadi, Mojtaba Heydari, Majid Nimrouzi, Pouya Faridi, Mohammad Javad Zibaeenezhad, Gholamhossein Ranjbar Omrani, Mesbah Shams . Rhus coriaria L. increases serum apolipoprotein-A1 and high-density lipoprotein cholesterol levels: A double-blind placebo-controlled randomized clinical trial. Journal of Integrative Medicine, 2018, 16(1): 45-50.
[9] Laura Belland, Laura Rivera-Reyes, Ula Hwang. Using music to reduce anxiety among older adults in the emergency department: A randomized pilot study. Journal of Integrative Medicine, 2017, 15(6): 450-455.
[10] Hilal Yuksel, Yasemin Cayir, Zahide Kosan, Kenan Tastan. Effectiveness of breathing exercises during the second stage of labor on labor pain and duration: A randomized controlled trial. Journal of Integrative Medicine, 2017, 15(6): 456-461.
[11] Maryam Sharifi-Ardani, Leili Yekefallah, Saeed Asefzadeh, Marjan Nassiri-Asl. Efficacy of topical chamomile on the incidence of phlebitis due to an amiodarone infusion in coronary care patients: A double-blind, randomized controlled trial. Journal of Integrative Medicine, 2017, 15(5): 373-378.
[12] Yoshiharu Motoo, Takashi Hakamatsuka, Nobuo Kawahara, Ichiro Arai, Kiichiro Tsutani. Standards of Reporting Kampo Products (STORK) in research articles. Journal of Integrative Medicine, 2017, 15(3): 182-185.
[13] Maria T.Chao, AlexandraChang, SanjayReddy, James D.Harrison, JosephAcquah, MiriaToveg, TrilceSantana, Frederick M.Hecht. Adjunctive acupuncture for pain and symptom management in the inpatient setting: Protocol for a pilot hybrid effectiveness-implementation study. Journal of Integrative Medicine, 2016, 14(3): 228-238.
[14] Nouran A. Aleyeidi, Khaled S. Aseri, Shadia M. Matbouli, Albaraa A. Sulaiamani, Sumayyah A. Kobeisy. Effects of wet-cupping on blood pressure in hypertensive patients: A randomized controlled trial. Journal of Integrative Medicine, 2015, 13(6): 391-399.
[15] Maria Sousa Cláudia, Coimbra Daniela, Machado Jorge, J. Greten Henry. Effects of self-administered exercises based on Tuina techniques on musculoskeletal disorders of professional orchestra musicians: A randomized controlled trial. Journal of Integrative Medicine, 2015, 13(5): 314-318.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Hao Li, Ming-jiang Yao, Wen-ming Zhao, Jie Guan, Lin-lin Cai, Ling Cui. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment. Journal of Chinese Integrative Medicine, 2008, 6(1): 25-31
[2] Jun Cai, Hua Wang, Sheng Zhou, Bin Wu, Hua-rong Song, Zheng-rong Xuan. Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(1): 37-40
[3] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[4] SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5] Wei Zhang, Xiang-feng Lu, Xiao-mei Zhang, Jian-jun Wu, Liang-duo Jiang. A rat model of pulmonary fibrosis induced by infusing bleomycin quickly through tracheal intubation. Journal of Chinese Integrative Medicine, 2008, 6(1): 60-67
[6] Guo-hong Yuan, Xiao-jing Pang, He-chao Ma. Synergic effects of Danggui Buxue Decoction in reducing toxicity of cytoxan in tumor-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 83-88
[7] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. Guiding principles of clinical research on mild cognitive impairment (protocol). Journal of Chinese Integrative Medicine, 2008, 6(1): 9-14
[8] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[9] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022
[10] Bing Hu , Hong-mei An , Ke-ping Shen , Qin Du. Senescence-inducing effects of Chinese herbal medicine Tenglong Buzhong Decoction on human colon carcinoma LS-174-T cells and the mechanism. Journal of Chinese Integrative Medicine, 2010, 8(11): 1048-1052
Journal of Integrative Medicine, ISSN: 2095-4964 CN 31-2083/R
Copyright © Journal of Integrative Medicine
Powered by Beijing Magtech Co. Ltd
沪公网安备31010602003416号      沪ICP备18017633号-3