“肾藏志应恐”有关神经生物学机制的研究思路

doi:10.3736/jcim20100202

Abstract

The theory of traditional Chinese medicine (TCM) deems that kidney essence is the material basis of formation, development and function of the brain and it maintains human being's psychomotility and behavior. Moreover, kidney essence is the material basis of emotional activity. The emotion theory in TCM deems that kidney stores will and responds to fear. The so called will in this theory refers to memory which includes three basic steps such as memorization, storage and recollection. Meanwhile, Western medicine considers stress as a kind of information that forms memory trace in central nervous system. Combining the TCM theory with the modern psychological theory on stress, and from the points of views of the emotion regulation, the formation, consolidation, extraction and extinction of fear memory, and the plasticity of amygdala-hippocampus-prefrontal cortex nervous pathway, as well as the results of pharmacological studies of prescriptions and herbs for invigorating the kidney, the authors explained in this article the pathological mechanisms of kidney deficiency due to attack of fear, and revealed the material basis, the action modes, and the neurobiological mechanisms of the kidney in controlling and regulating emotional activity.

Key words: Kidney qi, Jing (traditional Chinese medicine), Emothion-thought (TCM etiology), Fear, Memory

Shu-kao Liu, Can Yan, Li-li Wu, Yi Pan. Study strategies for neurobiology mechanism of "kidney storing will and responding to fear". Journal of Chinese Integrative Medicine, 2010, 8(2): 106-110.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20100202

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[1]	Dong XY, Li L. Psychology foundation of traditional Chinese medicine[J].Beijing: Beijing Science and Technology Pres, 2003,35
	董湘玉, 李琳 . 中医心理学基础[J].北京: 北京科学技术出版社, 2003,35
[2]	Chrousos GP , McCarty R, Pacak K, Cizza G, Sternberg E, Cold PW, Kvetnansky R.Stress: basic mechanisms and clinical implications[J]. New York: New York Academy of Sciences, 1995: 1-130
[3]	Csermely P . Stress of life: from molecules to man[J]. New York: New York Academy of Sciences, 1998: 1-547
[4]	Friedman MJ, Charney DS, Deutch AY . Neurobiological and clinical consequences of stress: from normal adaptation to post-traumatic stress disorder[J]. Philadelphia: Lippincott-Raven Publishers, 1995: 1-368
[5]	Tang QS, Bao ZX, Qu M, Zhao J . A discussion on the relationship between the kidney and mental emotion[J]. Beijing Zhong Yi, 2006,25(9):538-540
	唐启盛, 包祖晓, 曲淼, 赵晶 . 肾与神志关系的探讨[J]. 北京中医, 2006,25(9):538-540
[6]	Wu J, Yang SY . Treatment of anxiety disorders according to kidney aspect[J]. Liaoning Zhong Yi Yao Da Xue Xue Bao, 2007,9(2):12
	吴洁, 杨叔禹 . 从肾论治焦虑症[J]. 辽宁中医药大学学报, 2007,9(2):12
[7]	Xie LJ, Tang QS, Chang LG . Probe into treatment of depression according to kidney deficiency and stagnation of liver qi[J]. Jilin Zhong Yi Yao, 2007,27(1):15
	谢利军, 唐启盛, 常立果 . 从肾虚肝郁探讨抑郁症的治疗[J]. 吉林中医药, 2007,27(1):15
[8]	He WB, Zhang JL . Research and development of Bushen Recipe for promoting intelligence and treating Alzheimer's disease[J]. Zhong Yi Yao Xue Kan, 2004,22(5):856-857
	贺文彬, 张俊龙 . 补肾复方促智抗老年痴呆作用机制的研究述要[J]. 中医药学刊, 2004,22(5):856-857
[9]	Zhang XJ, Yan C, Gao M . Traditional Chinese medicine and regulation of sub-healthy state of psychogenous stress[J]. Zhong Yi Za Zhi, 2002,43(9):647-648
	张孝娟, 严灿, 高敏 . 中医药与心理应激亚健康状态的调节[J]. 中医杂志, 2002,43(9):647-648
[10]	Lai SL, Hu JQ, Wang Q, Wen ZH, Liang WX . Preventive effects of Bushen Yizhi Recipe on learning and memory in rats with Alzheimer’s disease[J]. Guangzhou Zhong Yi Yao Da Xue Xue Bao, 2000,17(2):106-109
	赖世隆, 胡镜清, 王奇, 温泽淮, 梁伟雄 . 补肾益智方对老年性痴呆大鼠学习记忆能力保护作用的观察[J]. 广州中医药大学学报, 2000,17(2):106-109
[11]	Hu JQ, Lai SL, Wang Q, Liang WX, Xie H . Protective effects of Bushen Yizhi decoction on brain cholinergic system in rats with Alzheimer's disease[J]. Guangzhou Zhong Yi Yao Da Xue Xue Bao, 1999,16(3):201
	胡镜清, 赖世隆, 王奇, 梁伟雄, 谢红 . 补肾益智方对阿尔茨海默病大鼠模型脑内胆碱能神经系统的保护作用[J]. 广州中医药大学学报, 1999,16(3):201
[12]	Lai SL, Rao Y, Gao J, Yu T, Wang Q, Hu JQ, Wang HX . Bushen Yizhi Recipe in improvement of learning and memory of rats with Alzheimer's disease[J]. Zhong Yao Xin Yao Yu Lin Chuang Yao Li, 2000,11(6):337-339
	赖世隆, 饶燕, 高洁, 于涛, 王奇, 胡镜清, 王怀星 . 补肾益智方改善Alzheimer病模型大鼠的学习记忆能力[J]. 中药新药与临床药理, 2000,11(6):337-339
[13]	Rao Y, Lai SL, Hu JQ, Wang Q . Effects of Bushen Yizhi decoction on hippocampal long term potentiation in rat model with Alzheimer’s disease[J]. Guangzhou Zhong Yi Yao Da Xue Xue Bao, 2000,17(2):109-112
	饶燕, 赖世隆, 胡镜清, 王奇 . 补肾益智方对老年性痴呆大鼠突触传递长时程增强的影响[J]. 广州中医药大学学报, 2000,17(2):109-112
[14]	Shen ZY . Rule of tonifying the kidney in regulating T lymphocyte apoptosis of kidney-yang deficiency: plasticity of gene balance[J]. J Chin Integr Med, 2004,2(5):321-322
	沈自尹 . 补肾法调节肾阳虚证T细胞凋亡的规律——重塑基因平衡[J]. 中西医结合学报, 2004,2(5):321-322
[15]	Jin GQ, Dai WW, Zhou GQ . Experimental study of kidney-nourishing herbs in retarding senescence of limbic system in senile rat brain[J]. Zhongguo Lao Nian Xue Za Zhi, 2004,24(7):169-170
	金国琴, 戴薇薇, 周国琪 . 补肾方药延缓老年大鼠大脑边缘系统衰老的实验研究[J]. 中国老年学杂志, 2004,24(7):169-170
[16]	Dai WW, Jin GQ, Zhang XL, Xu PC, Zhao WK . Effects of Zuoguiwan and Youguiwan on content changes of neurotransmitter amino acids in hippocampus and amygdaloidal nucleus in senile rats[J]. Zhonghua Zhong Yi Yao Za Zhi, 2005,20(7):397-400
	戴薇薇, 金国琴, 张学礼, 徐品初, 赵伟康 . 左归丸、右归丸对老年大鼠海马、杏仁核氨基酸类神经递质含量变化的影响[J]. 中华中医药杂志, 2005,20(7):397-400
[17]	Dai WW, Jin GQ, Zhang XL, Wang YJ, Xu PC . Effects of Zuogui Wan and Yougui Wan on cognition-related gene BDNF mRNA expressions in the aging rats' hippocampus[J]. Zhong Yao Yao Li Yu Lin Chuang, 2007,23(4):14-16
	戴薇薇, 金国琴, 张学礼, 王亚娟, 徐品初 . 左归丸、右归丸对衰老大鼠海马学习记忆相关基因BDNF mRNA表达的影响[J]. 中药药理与临床, 2007,23(4):14-16
[18]	Dai WW, Jin GQ, Zhang XL, Xia HAY, Li ZP, Gong ZB, Yao LA, Kang XP, Zhang LN, Wang YJ, Xu PC . Effects of kidney-nourishing herbs on cognition-related gene BDNF and its receptor TrkB mRNA expressions in aging rats' hippocampus[J]. Zhonghua Zhong Yi Yao Za Zhi, 2008,23(4):296-299
	戴薇薇, 金国琴, 张学礼, 夏花阿英, 黎志萍, 龚张斌, 姚领爱, 康湘萍, 张丽娜, 王亚娟, 徐品初 . 补肾方药对衰老大鼠海马学习记忆相关基因BDNF及其受体TrkB mRNA表达的影响[J]. 中华中医药杂志, 2008,23(4):296-299
[19]	Tian GQ, Guo SS, Lu HQ . Effect of Bushen Huoxue recipe on learning and memory dysfunction and hippocampal nerve cell apoptosis in mice with cerebral ischemia/reperfusion injury[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2003,23(2):123-127
	田国庆, 郭赛珊, 卢贺起 . 补肾活血方对缺血再灌注脑损伤小鼠学习记忆功能及海马神经细胞凋亡的影响[J]. 中国中西医结合杂志, 2003,23(2):123-127
[20]	Liu WY, Zhang J . Progress in research of mechanisms of fear conditioning reflex[J]. Guo Ji Ma Zui Xue Yu Fu Su Za Zhi, 2007,28(1):66-69
	刘文义, 张锦 . 恐惧条件反射机制研究的新进展[J]. 国际麻醉学与复苏杂志, 2007,28(1):66-69
[21]	Tao R, Zhang YL . Progress in research of neurobiology mechanisms of amygdala in conditioned fear[J]. Zhonghua Jing Shen Ke Za Zh, 2006,39(1):58-60
	陶嵘, 张亚林 . 杏仁核在条件恐惧中神经生物学机制的研究进展[J]. 中华精神科杂志, 2006,39(1):58-60
[22]	Cheng DT, Knight DC, Smith CN, Stein EA, Helmstetter FJ . Functional MRI of human amygdala activity during pavlovian fear conditioning: stimulus processing versus response expression[J]. Behav Neurosci, 2003,117(1):3-10 doi: 10.1037/0735-7044.117.1.3
[23]	Li LJ, Yang JL . Neurobiology mechanisms of psyche trauma-related memory[J]. Guo Wai Yi Xue Jing Shen Bing Xue Fen Ce, 2004,31(4):193-196
	李凌江, 杨建立 . 精神创伤性记忆的生物学机制[J]. 国外医学精神病学分册, 2004,31(4):193-196
[24]	Kim JJ, Diamond DM . The stressed hippocampus, synaptic plasticity and lost memories[J]. Nat Rev Neurosci, 2002,3(6):453-462
[25]	Myers KM, Davis M . Behavioral and neural analysis of extinction[J]. Neuron, 2002,36(4):567-584 doi: 10.1016/S0896-6273(02)01064-4
[26]	Pare D, Quirk GJ, Ledoux JE . New vistas of amygdala networks in conditioned fear[J]. J Neurophysiol, 2004,92(1):1-9 doi: 10.1152/jn.00153.2004
[27]	Shen Y, Kuang TY, Zhang WR, Xiao Y, Zhang J . An experimental research on the theory of “fright injuring kidney”[J]. Zhongguo Yi Yao Xue Bao, 1991,6(1):13
	沈雁, 匡调元, 张伟荣, 肖颐, 张俊 . “恐伤肾”的实验研究[J]. 中国医药学报, 1991,6(1):13
[28]	Wang MQ, Lin Q, Liu ST, Yan SL, Ma XD, Yu T, Lu ZH, Peng XF . Genetic experiment study of filial generation behavior in rats with inherent kidney deficiency syndrome[J]. Zhong Yi Za Zhi, 1998,39(9):560
	王米渠, 林乔, 刘绍唐, 严石林, 马向东, 于挺, 卢朝晖, 彭兴甫 . 先天肾虚证造模种鼠子代行为的遗传实验研究[J]. 中医杂志, 1998,39(9):560
[29]	Han TZ, Wu FM. Neurobiology of learning and memory[J].Beijing: United Publishing House of Beijing Medical University and Chinese Union Medical University, 1998: 262-286
	韩太真, 吴馥梅 . 学习与记忆的神经生物学[J].北京: 北京医科大学中国协和医科大学联合出版社, 1998: 262-286
[30]	Han JS. Essentials of neuroscience[J].Beijing: United Publishing House of Beijing Medical University and Chinese Union Medical University, 1993: 749-803
	韩济生 . 神经科学纲要[J].北京: 北京医科大学中国协和医科大学联合出版社, 1993: 749-803

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Study strategies for neurobiology mechanism of "kidney storing will and responding to fear"

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