Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (10): 1088-1091.doi: 10.3736/jcim20121004

Previous Articles     Next Articles

Three-factor designs unable to examine the interactions (Part 1)

Liang-ping Hu(), Xiao-lei Bao#br#   

  1. Consulting Center of Biomedical Statistics, Academy of Military Medical Sciences, Beijing 100850, China
  • Received:2012-08-25 Accepted:2012-08-31 Online:2012-10-20 Published:2018-10-15
  • Contact: Liang-ping Hu E-mail:lphu812@sina.com

Three-factor designs that are unable to examine the interactions include crossover design and Latin square design, which can examine three factors, namely, an experimental factor and two block factors. Although the two design types are not quite frequently used in practical research, an unexpected research effect will be achieved if they are correctly adopted on appropriate occasions. Due to the limit of space, this article introduces two forms of crossover design.

Key words: statistics, medical, research design, factor analysis, statistical

"

Research subjects Drugs and PWC170
Winter Spring
1 A 159.4 B 153.8
2 B 129.4 A 159.8
3 B 122.1 A 137.6
4 A 130.4 B 137.8
5 A 150.7 B 140.2
6 B 129.9 A 146.1
7 B 166.3 A 210.9
8 A 208.7 B 169.9
9 A 180.1 B 150.7
10 B 143.4 A 150.8

"

Participants Doses and food intake
1 2 3
1 A (xx) B (xx) A (xx)
2 A (xx) B (xx) A (xx)
24 A (xx) B (xx) A (xx)
25 B (xx) A (xx) B (xx)
26 B (xx) A (xx) B (xx)
48 B (xx) A (xx) B (xx)
[1] Hu LP. The application of statistical triple-type theory in experimental designs[M]. Beijing: People’s Military Medical Press, 2006, 71-84
胡良平 . 统计学三型理论在实验设计中的应用[M]. 北京: 人民军医出版社, 2006, 71-84
[2] Anton SD, Shuster J, Leeuwenburgh C . Investigations of botanicals on food intake, satiety, weight loss and oxidative stress: study protocol of a double-blind, placebo-controlled, crossover study[J]. J Chin Integr Med, 2011,9(11):1190-1198
Anton SD, Shuster J, Leeuwenburgh C. “双盲、安慰剂对照交叉设计研究植物药对于进食量、饱腹感、体重减轻及氧化应激的影响”的研究方案[J]. 中西医结合学报, 2011,9(11):1190-1198
[1] Seung-hoon Choi. A digital application for implementing the ICD-11 traditional medicine chapter. Journal of Integrative Medicine, 2020, 18(6): 455-458.
[2] Luciana Aikawa, Alexandre Massao Yoshizumi, Mirian Matsura Shirassu, Marcia Kiyomi Koike. Rapid acupuncture for musculoskeletal pain in the emergency room of the Hospital Servidor Publico Estadual, Brazil: A quasi-experimental study. Journal of Integrative Medicine, 2020, 18(4): 313-318.
[3] Lena Grönblom Lundström, Ulrika Aasa, Yan Zhang, Tobias Sundberg. Health care in light of different theories of health—A proposed framework for integrating a social humanistic perspective into health care. Journal of Integrative Medicine, 2019, 17(5): 321-327.
[4] Mohammad Hossein Ayati, Ata Pourabbasi, Nazli Namazi, Arman Zargaran, Zahra Kheiry, Amir Hooman Kazemi, Bagher Larijani. The necessity for integrating traditional, complementary, and alternative medicine into medical education curricula in Iran. Journal of Integrative Medicine, 2019, 17(4): 296-301.
[5] Bellavite Paolo, Marzotto Marta, Bonafini Clara. Arnica montana experimental studies: Confounders and biases?. Journal of Integrative Medicine, 2018, 16(2): 72-76.
[6] Saswati Mahapatra, Anjali Bhagra, Bisrat Fekadu, Zhuo Li, Brent A. Bauer, Dietlind L. Wahner-Roedler. Incorporation of integrative medicine education into undergraduate medical education: A longitudinal study. Journal of Integrative Medicine, 2017, 15(6): 442-449.
[7] Salvatore Chirumbolo, Geir Bjørklund. Homeopathic potencies of Arnica montana L. change gene expression in a Tamm-Horsfall protein-1 cell line in vitro model: The role of ethanol as a possible confounder and statistical bias. Journal of Integrative Medicine, 2017, 15(4): 255-264.
[8] Gerard Flaherty, Jenny Fitzgibbon, Peter Cantillon. Attitudes of medical students toward the practice and teaching of integrative medicine. Journal of Integrative Medicine, 2015, 13(6): 412-415.
[9] Maizes Victoria, Horwitz Randy, Lebensohn Patricia, McClafferty Hilary, Dalen James, Weil Andrew. The evolution of integrative medical education: the influence of the University of Arizona Center for Integrative Medicine. Journal of Integrative Medicine, 2015, 13(6): 356-362.
[10] Arthur Yin Fan. The methodology flaws in Hinman’s acupuncture clinical trial, Part II: Zelen design and effectiveness dilutions. Journal of Integrative Medicine, 2015, 13(3): 136-139.
[11] Arthur Yin Fan. The methodology flaws in Hinman’s acupuncture clinical trial, Part I: Design and results interpretation. Journal of Integrative Medicine, 2015, 13(2): 65-68.
[12] Hai-Yong Chen​, Yibin Feng​, Lixing Lao​. Chinese integrative medicine: Inclusion of a Chinese medicine programme in a conventional medical institute. Journal of Integrative Medicine, 2014, 12(3): 187-190.
[13] Subhranil Saha​, Munmun Koley, Jogendra Singh Arya, Gurudev Choubey, Shubhamoy Ghosh​, Subhasish Ganguly​, Aloke Ghosh​, Sangita Saha​, Malay Mundle​. Medicine prescription practices of homeopathic undergraduate students in West Bengal, India. Journal of Integrative Medicine, 2014, 12(1): 7-12.
[14] Liang-ping Hu, Xiao-lei Bao, Chen-long Lv. Two-factor designs unable to examine the interactions (Part 2). Journal of Chinese Integrative Medicine, 2012, 10(9): 966-969.
[15] Ming T. Tan , Jian-ping Liu , Lixing Lao. Adequate application of quantitative and qualitative statistic analytic methods in acupuncture clinical trials. Journal of Chinese Integrative Medicine, 2012, 10(8): 847-852.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228