Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2013, Vol. 11 ›› Issue (6): 422-427.doi: 10.3736/jintegrmed2013055

Special Issue: Acupuncture & Moxibustion

• Case Report • Previous Articles     Next Articles

Integrative techniques using acupuncture, Chinese herbal medicine, diet, and supplements for polycystic ovary syndrome: A case report

Dagmar Ehling   

  1. Oriental Health Solutions, LLC., Durham, North Carolina 27705, USA
  • Received:2013-06-24 Accepted:2013-09-11 Online:2013-11-10 Published:2013-11-15

Key words: Polycystic ovary syndrome, Infertility, Hashimoto disease, Acupuncture therapy, Medicine, Chinese raditional, Medicine, Herbal, Diet, Dietary supplements, Case reports

[1] Lucidi RS. Polycystic ovarian syndrome. (2013-03-04)[ 2013-05-07]. .
[2] Madnani N, Khan K, Chauhan P, Parmar G . Polycystic ovarian syndrome[J]. Indian J Dermatol Venereol Leprol, 2013,79(3):310-321
doi: 10.4103/0378-6323.110759
[3] Seccombe A. New research finds genetic defect linking PCOS and insulin resistance. (2013-03-20)[ 2013-05-07]. .
[4] Hyman M . The blood sugar solution. New York: Little, Brown andCompany. 2012.
[5] Nugent BM, Tobet SA, Lara HE, Lucion AB, Wilson ME, Recabarren SE, Paredes AH . Hormonal programming across the lifespan[J]. Horm Metab Res, 2012,44(8):577-586
doi: 10.1055/s-00000025
[6] Bayol SA, Simbi BH, Bertrand JA, Stickland NC . Offspring from mothers fed a ‘junk food’ diet in pregnancy and lactation exhibit exacerbated adiposity that is more pronounced in females[J]. J Physiol, 2008,586(Pt 13):3219-3230
doi: 10.1113/jphysiol.2008.153817
[7] United States Department of Agriculture. Agriculture factbook 2001-2002: profiling food consumption in America. ( 2002)[ 2013-05-07]. .
[8] United States Department of Agriculture, Center for Nutrition Policy and Promotion. The food guide pyramid. .
[9] United States Department of Agriculture. Choose my plant.[ 2013-05-07]. .
[10] New Hampshire Division of Public Health Services ( DHHS-DPHS) Health Promotion in Motion . How much sugar do you eat? You may be surprised![ 2013-05-07]. .
[11] Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, Lin JK, Farzadfar F, Khang YH, Stevens GA, Rao M, Ali MK, Riley LM, Robinson CA, Ezzati M; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Blood Glucose).National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants[J]. Lancet, 2011,378(9785):31-40
doi: 10.1016/S0140-6736(11)60679-X
[12] Wikipedia. Insulin resistance.[ 2013-05-07]. .
[13] Wikipedia. Aromatase. [ 2013 .
[14] Kluczynik CE, Mariz LS, Souza LC, Solano GB, Albuquerque FC, Medeiros CC . Acanthosis nigricans and insulin resistance in overweight children and adolescents[J]. An Bras Dermatol, 2012,87(4):531-537
doi: 10.1590/S0365-05962012000400002
[15] Barbato MT, Criado PR, Silva AK, Averbeck E, Guerine MB, Sá NB . Association of acanthosis nigricans and skin tags with insulin resistance[J]. An Bras Dermatol, 2012,87(1):97-104
doi: 10.1590/S0365-05962012000100012
[16] Abraham C, Rozmus CL . Is acanthosis nigricans a reliable indicator for risk of type 2 diabetes in obese children and adolescents? A systematic review[J]. J Sch Nurs, 2012,28(3):195-205
doi: 10.1177/1059840511430952
[17] Garelli S, Masiero S, Plebani M, Chen S, Furmaniak J, Armanini D, Betterle C . High prevalence of chronic thyroiditis in patients with polycystic ovary syndrome[J]. Eur J Obstet Gynecol Reprod Biol, 2013,169(2):248-251
doi: 10.1016/j.ejogrb.2013.03.003
[18] Janssen OE, Mehlmauer N, Hahn S, Offner AH , G?rtner R.High prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome[J]. Eur J Endocrinol, 2004,150(3):363-369
doi: 10.1530/eje.0.1500363
[19] González F . Inflammation in polycystic ovary syndrome: underpinning of insulin resistance and ovarian dysfunction[J]. Steroids, 2012,77(4):300-305
doi: 10.1016/j.steroids.2011.12.003
[21] Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B . Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes[J]. Am J Clin Nutr, 2006,84(1):18-28
doi: 10.1093/ajcn/84.1.18
[22] Duleba AJ, Dokras A . Is PCOS an inflammatory process? Fertil Steril. 2012; 97(1):7-12.
doi: 10.1016/j.fertnstert.2011.11.023
[23] Gonzalez F, Thusu K, Abdel-Rahman E, Prabhala A, Tomani M, Dandona P . Elevated serum levels of tumor necrosis factor alpha in normal-weight women with polycystic ovary syndrome[J]. Metabolism, 1999,48(4):437-441
doi: 10.1016/S0026-0495(99)90100-2
[24] Wikipedia. Tyrosine. [ 2013 .
[25] Wikipedia. Thyroid hormone.[ 2013-05-07]. .
[26] Wikipedia. Acetylcholine. [ 2013 .
[27] Zeisel SH, Mar MH, Howe JC, Holden JM . Concentrations of choline-containing compounds and betaine in common foods[J]. J Nutr, 2003,133(5):1302-1307
doi: 10.1093/jn/133.5.1302
[28] Matsumoto K, Euler D . Kiiko Matsumoto’s clinical strategies. Vol 1 and Vol 2. Natick:Kiiko Matsumoto International. 2004.
[29] Marcotorchino J, Gouranton E, Romier B, Tourniaire F, Astier J, Malezet C, Amiot MJ, Landrier JF . Vitamin D reduces the inflammatory response and restores glucose uptake in adipocytes[J]. Mol Nutr Food Res, 2012,56(12):1771-1782
doi: 10.1002/mnfr.v56.12
[30] Biesalski HK . Vitamin D recommendations: beyond deficiency[J]. Ann Nutr Metab, 2011,59(1):10-16
doi: 10.1159/000332066
[31] Sainaghi PP, Bellan M, Nerviani A, Sola D, Molinari R, Cerutti C, Pirisi M . Superiority of a high loading dose of cholecalciferol to correct hypovitaminosis d in patients with inflammatory/autoimmune rheumatic diseases[J]. J Rheumatol, 2013,40(2):166-172
doi: 10.3899/jrheum.120536
[32] Olafsdottir AS, Magnusardottir AR, Thorgeirsdottir H, Hauksson A, Skuladottir GV, Steingrimsdottir L . Relationship between dietary intake of cod liver oil in early pregnancy and birthweight[J]. BJOG, 2005,112(4):424-429
doi: 10.1111/bjo.2005.112.issue-4
[33] Kelly GS . Hydrochloric acid: physiological functions and clinical implications[J]. Altern Med Rev, 1997,2(2):116-127
[34] Ak?ay MN , Akay G. The presence of the antigliadin antibodies in autoimmune thyroid diseases. Hepatogastroenterology. 2003; 50 (Suppl 2): cclxxix-cclxxx.
[35] Shaoul R, Lerner A . Associated autoantibodies in celiac disease[J]. Autoimmun Rev, 2007,6(8):559-565
doi: 10.1016/j.autrev.2007.02.006
[36] da Silva Kotze LM, Nisihara RM, da Rosa Utiyama SR, Piovezan GC, Kotze LR . Thyroid disorders in Brazilian patients with celiac disease[J]. J Clin Gastroenterol, 2006,40(1):33-36
doi: 10.1097/01.mcg.0000190756.63799.0f
[37] Ventura A, Magazzù G, Greco L . Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease[J]. Gastroenterology, 1999,117(2):297-303
doi: 10.1053/gast.1999.0029900297
[38] Barton SH, Murray JA . Celiac disease and autoimmunity in the gut and elsewhere. Gastroenterol Clin North Am. 2008; 37(2): 411-428, vii.
doi: 10.1016/j.gtc.2008.02.001
[39] Duggan JM . Coeliac disease: the great imitator[J]. Med J Aust, 2004,180(10):524-526
[40] Zold E, Szodoray P, Kappelmayer J, Gaal J, Csathy L, Barath S, Gyimesi E, Hajas A, Zeher M, Szegedi G, Bodolay E . Impaired regulatory T-cell homeostasis due to vitamin D deficiency in undifferentiated connective tissue disease[J]. Scand J Rheumatol, 2010,39(6):490-497
doi: 10.3109/03009741003781951
[41] Fraternale A, Paoletti MF, Casabianca A, Oiry J, Clayette P, Vogel JU, Cinatl J Jr, Palamara AT, Sgarbanti R, Garaci E, Millo E, Benatti U, Magnani M . Antiviral and immunomodulatory properties of new pro-glutathione(GSH) molecules[J]. Curr Med Chem, 2006,13(15):1749-1755
doi: 10.2174/092986706777452542
[42] Paolicchi A, Dominici S, Pieri L, Maellaro E, Pompella A . Glutathione catabolism as a signaling mechanism[J]. Biochem Pharmacol, 2002,64(5-6):1027-1035
doi: 10.1016/S0006-2952(02)01173-5
[43] Weschler T . Taking charge of your fertility. New York:HarperCollins Publishers Inc. 2002.
[44] How much will my fertility treatments and drugs cost? ( 2013-01-04) .
[45] Rathnayake D, Sinclair R . Innovative use of spironolactone as an antiandrogen in the treatment of female pattern hair loss[J]. Dermatol Clin, 2010,28(3):611-618
doi: 10.1016/j.det.2010.03.011
[46] Hwang KR, Choi YM, Kim JJ, Chae SJ, Park KE, Jeon HW, Ku SY, Kim SH, Kim JG, Moon SY . Effects of insulin-sensitizing agents and insulin resistance in women with polycystic ovary syndrome[J]. Clin Exp Reprod Med, 2013,40(2):100-105
doi: 10.5653/cerm.2013.40.2.100
[47] Rice S, Elia A, Jawad Z, Pellatt L, Mason HD . Metformin inhibits follicle-stimulating hormone(FSH) action in human granulosa cells: relevance to polycystic ovary syndrome[J]. J Clin Endocrinol Metab, 2013,98(9):E1491-E1500
doi: 10.1210/jc.2013-1865
[48] Zheng YH, Wang XH, Lai MH, Yao H, Liu H, Ma HX . Effectiveness of abdominal acupuncture for patients with obesity-type polycystic ovary syndrome: a randomized controlled trial[J]. J Altern Complement Med, 2013,19(9):740-745
doi: 10.1089/acm.2012.0429
[49] Stener-Victorin E, Jedel E, Janson PO, Sverrisdottir YB . Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome[J]. Am J Physiol Regul Integr Comp Physiol, 2009,297(2):R387-R395
doi: 10.1152/ajpregu.00197.2009
[50] An Y, Sun Z, Zhang Y, Liu B, Guan Y, Lu M. The use of berberine for women with polycystic ovary syndrome undergoing IVF treatment. Clin Endocrinol ( Oxf). 2013 Jul 19. [Epub ahead of print]
[51] Westman EC, Feinman RD, Mavropoulos JC, Vernon MC, Volek JS, Wortman JA, Yancy WS, Phinney SD . Low-carbohydrate nutrition and metabolism[J]. Am J Clin Nutr, 2007,86(2):276-284
doi: 10.1093/ajcn/86.2.276
[52] O’Dea K . Marked improvement in carbohydrate and lipid metabolism in diabetic Australian aborigines after temporary reversion to traditional lifestyle[J]. Diabetes, 1984,33(6):596-603
doi: 10.2337/diab.33.6.596
[53] Yang SZ, Li DW. Fu Qing-Zhu’s gynecology. Boulder: Blue Poppy Press, Inc. 1996.
[54] Maciocia G . Obstetrics & gynecology in Chinese medicine. New York:Churchill Livingstone. 1998.
[55] Jones DS . Textbook of functional medicine. Gig Harbor: The Institute ofFunctional Medicine. 2010.
[1] Brody Slostad, Tejinder Khalsa, Kathleen Young, Hildalicia Guerra, Anjali Bhagra. A case-based approach to integrative medicine for cardiovascular disease prevention. Journal of Integrative Medicine, 2020, 18(2): 159-162.
[2] Ameena Yasmeen, Ghulamuddin Sofi, Kaleemullah Khan. Aamar-e-Advia (shelf-lives) of drugs in Unani system of medicine: A conceptual review. Journal of Integrative Medicine, 2020, 18(2): 114-124.
[3] Louisa Sylvia, Emerson West, Allyson M. Blackburn, Carina Gupta, Eric Bui, Tara Mahoney, Geraldine Duncan, Edward C. Wright, Simon Lejeune, Thomas J. Spencer. Acceptability of an adjunct equine-assisted activities and therapies program for veterans with posttraumatic stress disorder and/or traumatic brain injury. Journal of Integrative Medicine, 2020, 18(2): 169-173.
[4] Deng-hai Zhang, Kun-lun Wu, Xue Zhang, Sheng-qiong Deng, Bin Peng. In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus. Journal of Integrative Medicine, 2020, 18(2): 152-158.
[5] Chang-quan Ling. Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2). Journal of Integrative Medicine, 2020, 18(2): 87-88.
[6] Sherman Gu, Arthur Yin Fan. Controversial conclusions from two randomized controlled trials for acupuncture's effects on polycystic ovary syndrome or in vitro fertilization support. Journal of Integrative Medicine, 2020, 18(2): 89-91.
[7] Xue-qing Yu, Shu-guang Yang, Yang Xie, Jian-sheng Li. Traditional Chinese medicine in the treatment of idiopathic pulmonary fibrosis based on syndrome differentiation: Study protocol of exploratory trial. Journal of Integrative Medicine, 2020, 18(2): 163-168.
[8] Mohadeseh Ostovar, Abolfazl Akbari, Mohammad Hossein Anbardar, Aida Iraji, Mohsen Salmanpour, Salar Hafez Ghoran, Mojtaba Heydari, Mesbah Shams. Effects of Citrullus colocynthis L. in a rat model of diabetic neuropathy. Journal of Integrative Medicine, 2020, 18(1): 59-67.
[9] Nadiah Razali, Aidiahmad Dewa, Mohd Zaini Asmawi, Nornisah Mohamed, Nurul Maizan Manshor. Mechanisms underlying the vascular relaxation activities of Zingiber officinale var. rubrum in thoracic aorta of spontaneously hypertensive rats. Journal of Integrative Medicine, 2020, 18(1): 46-58.
[10] Preecha Nootim, Nattiya Kapol, Waranee Bunchuailua, Panoopat Poompruek, Parankul Tungsukruthai . Current state of cancer patient care incorporating Thai traditional medicine in Thailand: A qualitative study. Journal of Integrative Medicine, 2020, 18(1): 41-45.
[11] Sajjad Sadeghi, Farzaneh Ghaffari, Ghazaleh Heydarirad, Mehdi Alizadeh. Galen’s place in Avicenna’s The Canon of Medicine : Respect, confirmation and criticism. Journal of Integrative Medicine, 2020, 18(1): 21-25.
[12] Maryam Naeimia, Narjes Gorjib, Zahra Memarianib, Reihaneh Moeinib, Mohammad Kamalinejadc, Fatemeh Kolangid. Gastroprotective herbs for headache management in Persian medicine: A comprehensive review. Journal of Integrative Medicine, 2020, 18(1): 1-13.
[13] Md. Anzar Alam, Mohd Aleemuddin Quamri, Ghulamuddin Sofi, Barkati Md.Tarique. Understanding hypothyroidism in Unani medicine. Journal of Integrative Medicine, 2019, 17(6): 387-391.
[14] Naghmeh Yazdi, Alireza Salehi, Mina Vojoud, Mohammad Hossein Sharifi, Ayda Hoseinkhani. Use of complementary and alternative medicine in pregnant women: a cross-sectional survey in the south of Iran. Journal of Integrative Medicine, 2019, 17(6): 392-395.
[15] Wen Qiang Lee, Jeremy Teoh, Pei Zheng Kenneth Lee, Zhi Xiong Gerard Low, Xueling Sim, Foong Fong Mary Chong, Norbert Ludwig Wagner. Factors influencing communication of traditional Chinese medicine use between patients and doctors: a multisite cross-sectional study. Journal of Integrative Medicine, 2019, 17(6): 396-403.
Full text



[1] Yi-ting He, Qing-lin Zha, Jian-ping Yu, Yong Tan, Cheng Lu, Ai-ping Lv. Principal factor analysis of symptoms of rheumatoid arthritis and their correlations with efficacy of traditional Chinese medicine and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 32-36
[2] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[3] Xi Lin, Jian-ping Liu. Tai chi for treating rheumatoid arthritis. Journal of Chinese Integrative Medicine, 2008, 6(1): 82
[4] Guo-hong Yuan, Xiao-jing Pang, He-chao Ma. Synergic effects of Danggui Buxue Decoction in reducing toxicity of cytoxan in tumor-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 83-88
[5] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[8] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[9] You-hua Wang , Shang Li , Bin-rui Yang , Lun-qing Zhang , Xin Zhou , Bei-wen Xu, Ming-yuan Li . Use of zebrafish models for the research of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1189-1197
[10] Gui Yu, Jie Wang. Thinking on building the network cardiovasology of Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1206-1210