新风胶囊对佐剂性关节炎大鼠行为及心肌超微结构的影响

doi:10.3736/jcim20080612

Abstract

Objective: To observe the effects of Xinfeng Capsule (XFC), a compound Chinese herbal medicine, on behaviors and myocardial ultrastructure in adjuvant arthritis (AA) rats.
Methods: Fifty-five rats were randomly divided into normal control group, untreated group, methotrexate (MTX) group, Tripterygium wilfordii glycosides tablet (TGT) group and XFC group. There were 11 rats in each group. Except for those in the normal control group, the rats in the other groups were all intracutaneously given 0.1 ml Freund's complete adjuvant in the right hind limb. Changes of behaviors and myocardial ultrastructure of the rats in different groups were observed.
Results: Voix pedis' swelling and arthritis index in XFC, MTX and TPT groups were all obviously improved as compared with the untreated group. After XFC treatment, the autonomic activities were obviously increased, number of errors in exercise period and test period were obviously decreased, step-down latency (SDL) was lengthened and escape latency (EL) was shortened. Overall structure of myocardial myofibril and the majority of cristae was intact in XFC group. The effects of XFC in improving the behaviors and myocardial ultrastructure were better than those of MTX and TPT.
Conclusion: Changes of behaviour and myocardial ultrastructure of AA rats can be observed. XFC can improve the myocardial ultrastructure of AA rats as well as their behaviors.

Key words: Xinfeng Capsule, adjuvant arthritis, behavior, myocardium, rats

CLC Number:

R737.9

Jian Liu, Xue-fang Yu, Rui-kai Zong. Effects of Xinfeng Capsule on behaviors and myocardial ultrastructure in adjuvant arthritis rats. Journal of Chinese Integrative Medicine, 2008, 6(6): 606-610.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20080612

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References 14

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Group	n	Body weight
Group	n	At day one	At day 19	At day 49
Normal control	11	217.27±27.87	262.27±12.52	327.27±59.64
Untreated	11	204.09.±23.86	217.27±40.27**	241.36±35.15**
MTX	11	211.36±22.92	224.09±31.61**	306.82±37.63^△
TGT	11	214.09±13.38	222.73±31.81**	311.64±65.33^△△
XFC	11	221.82±20.53	232.27±12.32*	358.18±85.42^△△▲□

Group	n	Voix pedis' swelling (ml)		Arthritis index
Group	n	At day 19	At day 49	At day 19	At day 49
Normal control	11	36.68±25.66	37.74±23.64	0.00±0.00	0.00±0.00
Untreated	11	71.80±21.24**	68.92±28.48**	7.27±1.01**	8.09±1.45**
MTX	11	59.27±15.48*	36.50±16.71^△△	6.82±0.75**	3.18±1.25**^△△
TGT	11	69.43±25.87**	51.73±11.74*▲	7.27±1.01**	5.36±2.46**^△△▲▲
XFC	11	65.37±20.78**	44.21±22.29^△△	7.45±1.13**	3.18±1.33**^△△□□

Group	n	Autonomic Activity	Step-down latency (s)	Escape latency (s)	Errors in exercise period	Errors in test period
Normal control	11	60.36±12.44	80.73±15.68^▲	10.73±2.97	3.64±1.29	1.45±0.69
Untreated	11	19.27±9.69**	41.27±9.18**	9.64±4.37**	9.55±1.63**	7.45±1.57**
MTX	11	52.45±12.30^△△	69.09±8.02*^△△	15.00±4.65^△△*	4.09±1.14^△△	2.28±1.01^△△
TGT	11	56.45±7.63^△△	74.18±7.45^△△	13.18±2.89^△△	3.46±1.04^△△	2.18±0.75^△△
XFC	11	60.09±7.49^△△	79.00±11.80^△△▲	13.09±4.16^△△	3.91±1.51^△△	2.00±1.09^△△

Effects of Xinfeng Capsule on behaviors and myocardial ultrastructure in adjuvant arthritis rats

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