扶正抑瘤颗粒对放疗食管癌患者癌组织中CD44v6与nm23-H1表达的影响

doi:10.3736/jcim20040406

Abstract

Objective: To evaluate the effects of Fuzheng Yiliu Granule on the expression of CD44v6 and nm23-H1 in esophageal carcinoma treated with radiotherapy.Methods: Sixty-three cases of esophageal carcinoma were randomly divided into two groups: Fuzheng Yiliu Granule plus radiotherapy treated group (n=30) and radiotherapy treated group (n=33). The carcinoma specimens were obtained through endoscopic biopsy before and after twenty-one days of treatment. The expression of CD44v6 and nm23-H1 was determined in the sixty-three specimens of esophageal carcinoma by immunohistochemical SABC methods.Results: After twenty-one days of treatment, the positive rates of CD44v6 in the Fuzheng Yiliu Granule plus radiotherapy treated group and the radiotherapy treated group were 40.0% and 69.7%, respectively, and there was significant difference between the two groups (P<0.05). The positive rates of nm23-H1 in the Fuzheng Yiliu Granule plus radiotherapy treated group and the radiotherapy treated group were 20.0% and 21.2%, respectively, and the difference was not significant between the two groups (P>0.05).Conclusio: Fuzheng Yiliu Granule can lower the expression of CD44v6 in esophageal carcinoma, and may prevent infiltration and lymph node metastasis of esophageal carcinoma.

Key words: Fuzheng Yiliu Granule, esophageal carcinoma, CD44v6, nm23-H1

CLC Number:

R289.5

Jian-xiong Zhao, Xue-feng Li. Effects of Fuzheng Yiliu Granule on expression of CD44v6 and nm23-H1 in esophageal carcinoma treated with radiotherapy. Journal of Chinese Integrative Medicine, 2004, 2(4): 262-264.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20040406

http://www.jcimjournal.com/EN/Y2004/V2/I4/262

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Group	n	CD44v6		nm23-H1
Group	n	Positive	Negative	Positive	Negative
Fuzheng Yiliu Granule plus radiotherapy treated group
Before treatment	30	21(70.00)	9 (30.00)	4(13.33)	26 (86.67)
After treatment	30	12(40.00) *	18 (60.00)	6(20.00)	24 (80.00)
Radiotherapy treated group
Before treatment	33	23(69.70)	10 (30.30)	6(18.18)	27 (81.82)
After treatment	33	23(69.70)	10 (30.30)	7(21.21)	26 (78.79)

Effects of Fuzheng Yiliu Granule on expression of CD44v6 and nm23-H1 in esophageal carcinoma treated with radiotherapy

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