Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (6): 407-411.doi: 10.3736/jcim20040602

Special Issue: Traditional Chinese Medicine

• Expert Forum • Previous Articles     Next Articles

Strategy for treating liver fibrosis by integration of the disease and its syndromes in traditional Chinese medicine

Ping Liu   

  1. Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Received:2004-09-23 Online:2004-11-20 Published:2018-10-20

The strategy for treating liver fibrosis in chronic hepatitis patients includes dispelling the etiological factors, inhibiting the inflammatory reaction, decreasing the sedimentation of extracellular matrix, accelerating the degradation of extracellular matrix, improving the microcirculatory and metabolic disturbance, and ameliorating the complicating diseases, etc. Researchers should pay attention to the liver function indexes in chronic liver disease in evaluating the therapeutic effects of anti-fibrosis. Effective etiological treatment should be considered as the first step in treating liver fibrosis in chronic hepatitis patients, and inhibiting the inflammatory reaction is one of the most important tactics for suppressing the development of fibrosis and for decreasing the incidence rate of liver cancer in chronic hepatitis patients. Treatment based on syndrome differentiation, a dynamic therapy aimed at the holistic pathological state, can improve the pathological state of the disease. It is especially important to take the advantages of the integration of traditional Chinese and western medicine in the clinical diagnostic and therapeutic procedure for increasing the therapeutic effect of live fibrosis.

Key words: liver fibrosis, integration of traditional Chinese and western medicine, therapies

CLC Number: 

  • R575.2
[1] 田中荣司. コンセンサス 2004 肝疾患治疗(第1版)[M]. 东京: ァ-クメディァ, 2004,( 第1版):78
[2] 张勘, 曾民德, 范竹萍 , 等. 上海市医学发展基金重点研究项目《肝纤维化非创伤性检测指标及有效干预措施的研究》的组织管理[J]. 肝脏, 2000,5(4):224-226
[3] 马安林, 侯俊兰, 张道明 , 等. 酒精性肝病形成纤维化的危险因素[J]. 中华肝脏病杂志, 2003,11(6):373-374
[4] Manns MP, McHutchison JG, Gordon SC , et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatictis C: a randomized trial[J]. Lancet, 2001,358(9286):958-965
doi: 10.1016/S0140-6736(01)06102-5
[5] Fried MW, Schiffman MI, Reddy KR , et al. Peginterferon alfa-2a plus ribavirin for chronic hepatictis C virus infection[J]. N Engl J Med, 2002,347(13):975-982
doi: 10.1056/NEJMoa020047 pmid: 12324553
[6] 周防武昭, 岸本幸广, 川崎宽中 . 肝線維化の治療[A]. 见: 川崎宽中. 肝臟病—今日の診断と最新の治療[M]. 东京: 国际医书出版, 1998. 165-174.
[7] Ikeda K, Saitoh S, Suzuki Y , et al. Interferon decreases hepatocellular carcinogenesis in patients with cirrhosis caused by the hepatitis B virus: a pilot study[J]. Cancer, 1998,82(5):827-835
doi: 10.1002/(ISSN)1097-0142
[8] Yuen MF, Hui CK, Cheng CC , et al. Long-term follow-up of interferon alfa treatment in Chinese patients with chronic hepatitis B infection: The effect on hepatitis B e antigen seroconversion and the development of cirrhosis-related complications[J]. Hepatology, 2001,34(1):139-145
doi: 10.1016/S0168-8278(01)81383-0
[9] Dienstag J, Goldin RD, Heathcote EJ , et al. Histological outcome during long-term lamivudine therapy[J]. Gastroenterol, 2003,124(1):105-117
doi: 10.1053/gast.2003.50013 pmid: 12512035
[10] Kweon YO, Goodman ZD, Dienstag JL , et al. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B[J]. J Hepatol, 2001,35(6):749-755
doi: 10.1016/S0168-8278(01)00218-5
[11] 谷川久一, 大槻真, 奥平雅彦 , 他.肝胆膵の線維化に関する諸问题[J]. 肝胆膵, 1998,37(3):425-441
[12] Emond JC, Whitington PF . Selective surgical management of progressive familial intrahepatic cholestasis(Byler's disease)[J]. J Pediatr Surg, 1995,30(12):1635-1641
doi: 10.1016/0022-3468(95)90440-9
[13] 荒濑康司, 池田健次, 熊田博光 . 慢性肝炎に对する强力ネオミノファ–ゲンシ–の效果[J]. 肝胆膵, 2002,44(3):303-310
[14] 蔡雄, 王国俊, 瞿瑶 , 等. 苦参素注射液治疗慢性乙型肝炎临床疗效分析[J]. 第二军医大学学报, 1997,18(1):47-49
doi: 10.1007/BF02951625
[15] 丁岩岩, 斯崇文, 曾争 , 等. 苦参素制剂治疗慢性乙型肝炎的临床试验[J]. 中华内科杂志, 2001,40(12):843-846
[16] 茅益民, 曾民德, 陆伦根 , 等. 氧化苦参碱胶囊治疗慢性病毒性肝炎肝纤维化的随机、双盲、安慰剂对照多中心临床研究(Ⅱ)[[J]. 肝脏, 2002,7(4):222-225
doi: 10.3969/j.issn.1008-1704.2002.04.003
[17] 韩经寰 . 强肝软坚汤治疗肝硬变105例临床观察[J]. 中华医学杂志, 1979,10(10):584-588
[18] 王宝恩, 赵洪涛 . 复方861对肝炎肝纤维化疗效的病理组织学分析[J]. 中华肝脏病杂志, 1997,5(2):77-78
[19] 易毛, 聂凌云, 刘云 , 等. 复方鳖甲软肝片的鉴别研究[J]. 中成药, 2002,24(5):349-352
[20] 刘平, 胡义杨, 刘成 , 等. 扶正化瘀胶囊干预慢性乙型肝炎肝纤维化作用的多中心临床研究[J]. 中西医结合学报, 2003,1(2):89-98
doi: 10.3969/j.issn.1008-861X.2002.01.013
Liu P, Hu YY, Liu C , et al. Multicenter clinical study about the action of Fuzheng Huayu Capsule against liver fibrosis with chronic hepatitis B[J]. Zhong Xi Yi Jie He Xue Bao, 2003,1(2):89-98
[21] 佘为民, 胡德昌, 周朝晖 , 等. 肝平胶囊治疗慢性乙型肝炎患者肝纤维化的临床研究[J]. 胃肠病学, 2002,7(B11):89-90
doi: 10.3969/j.issn.1008-1704.2002.04.014
[22] 持田智, 藤原研司 . 基础的研究—茵陈蒿汤[J]. 肝胆膵, 2002,44(3):335-339
[23] 山舖昌由. サィトヵィンの制御[J]. 肝胆膵, 2002,44(3):377-389
[24] Huang W, Zhang J, Moore DD . A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR[J]. J Clin Invest, 2004,113(1):137-143
doi: 10.1172/JCI200418385
[25] 刘平, 刘成, 陈高潮 , 等. 扶正化瘀319方治疗慢性乙型肝炎及其对纤维化血清学指标的影响[J]. 中国中西医结合杂志, 1996,16(10):588-592
doi: 10.7661/CJIM.1996.10.588
[26] 张杰, 徐列明 . 中医药治疗实验性肝纤维化作用机制研究进展[J]. 中西医结合学报, 2003,1(2):142-145
doi: 10.3969/j.issn.1009-3427.2003.04.008
Zhang J, Xu LM . Advances of mechanism research on treatment of experimental liver fibrosis with traditional Chinese medicine[J]. Zhong Xi Yi Jie He Xue Bao, 2003,1(2):142-145
[27] 刘平 . 理论联系实际,基础结合临床, 促进中西医结合肝脏病学科的发展[J]. 中西医结合学报, 2003,1(2):81-83
Liu P . Development of the integrated TCM hepatology with western medicine[J]. Zhong Xi Yi Jie He Xue Bao, 2003,1(2):81-83
[1] Peter Bablis, Henry Pollard, Anthony L. Rosner. Stress reduction via neuro-emotional technique to achieve the simultaneous resolution of chronic low back pain with multiple inflammatory and biobehavioural indicators: A randomized, double-blinded, placebo-controlled trial. Journal of Integrative Medicine, 2022, 20(2): 135-144.
[2] Jonathan M. Fields. Dangers of scientific bias against herbal drugs for coronavirus disease 2019. Journal of Integrative Medicine, 2020, 18(6): 459-461.
[3] Giles Gyer, Jimmy Michael, James Inklebarger, Jaya Shanker Tedla. Spinal manipulation therapy: Is it all about the brain? A current review of the neurophysiological effects of manipulation. Journal of Integrative Medicine, 2019, 17(5): 328-337.
[4] Richard A. Stein, Kira Schmid, Jowell Bolivar, Andrew G. Swick, Steven V. Joyal, Steven P. Hirsh . Kaempferia parviflora ethanol extract improves self-assessed sexual health in men: A pilot study. Journal of Integrative Medicine, 2018, 16(4): 249-254.
[5] Giles Gyer, Jimmy Michael, James Inklebarger. Occupational hand injuries: A current review of the prevalence and proposed prevention strategies for physical therapists and similar healthcare professionals. Journal of Integrative Medicine, 2018, 16(2): 84-89.
[6] Katy Andrade Monteiro Zacaron, Nélia da Silva Mendes, Yuri Cotta e Silva, Giancarlo Lucchetti. Effects of laying on of hands with and without a spiritual context on pain and functionality of older women with knee osteoarthritis: Study protocol for a randomized controlled trial. Journal of Integrative Medicine, 2018, 16(2): 106-112.
[7] Shubha Singhal, Vandana Roy. Awareness, practice and views about integrating AYUSH in allopathic curriculum of allopathic doctors and interns in a tertiary care teaching hospital in New Delhi, India. Journal of Integrative Medicine, 2018, 16(2): 113-119.
[8] Fabiana de Almeida Andrade, Caio Fabio Schlechta Portella. Research methods in complementary and alternative medicine: An integrative review. Journal of Integrative Medicine, 2018, 16(1): 6-13.
[9] Mohammadreza Bordbar, Mehdi Pasalar, Rezvan Aresehiri, Sezaneh Haghpanah, Soheila Zareifar, Fatemeh Amirmoezi. A cross-sectional study of complementary and alternative medicine use in patients with coagulation disorders in Southern Iran. Journal of Integrative Medicine, 2017, 15(5): 359-364.
[10] Yadaridee Viravud, Angkana Apichartvorakit, Pramook Mutirangura, Vasana Plakornkul, Jantima Roongruangchai, Manmas Vannabhum, Tawee Laohapand, Pravit Akarasereenont. The anatomical study of the major signal points of the court-type Thai traditional massage on legs and their effects on blood flow and skin temperature. Journal of Integrative Medicine, 2017, 15(2): 142-150.
[11] Udhaya Lavinya Baskaran, Evan Prince Sabina. Clinical and experimental research in antituberculosis drug-induced hepatotoxicity: A review. Journal of Integrative Medicine, 2017, 15(1): 27-36.
[12] Irene A. Kretchy, Harry A. Okere, Joseph Osafo, Barima Afrane, Joseph Sarkodie, Philip Debrah. Perceptions of traditional, complementary and alternative medicine among conventional healthcare practitioners in Accra, Ghana: Implications for integrative healthcare. Journal of Integrative Medicine, 2016, 14(5): 380-388.
[13] Molly J. Mallory, Alexander Do, Sara E. Bublitz, Susan J. Veleber, Brent A. Bauer, Anjali Bhagra. Puncturing the myths of acupuncture. Journal of Integrative Medicine, 2016, 14(5): 311-314.
[14] Ausanee Wanchai, Duangjai Phrompayak. Use of complementary and alternative medicine among Thai patients with type 2 diabetes mellitus. Journal of Integrative Medicine, 2016, 14(4): 297-305.
[15] Joseph Stewart Alter, Chandrashekar Sharma. Nature cure treatment in the context of India's epidemiological transition. Journal of Integrative Medicine, 2016, 14(4): 245-254.
Full text



[1] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[2] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[3] Xi Lin, Jian-ping Liu. Herbal medicines for viral myocarditis. Journal of Chinese Integrative Medicine, 2008, 6(1): 76
[4] Xi Lin, Jian-ping Liu. Tai chi for treating rheumatoid arthritis. Journal of Chinese Integrative Medicine, 2008, 6(1): 82
[5] Liang-ping Hu, Hui Gao. Discrimination of errors in statistical analysis of medical papers published in the first issue of 2006 in Journal of Chinese Integrative Medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 98-106
[6] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035
[7] Wei Xu, Meng Shi, Jian-gang Liu, Cheng-long Wang . Collagen protein expressions in ischemic myocardium of rats with acute myocardial infarction and effects of qi-tonifying, yin-tonifying and blood-activating herbs and detoxifying and blood-activating herbs. Journal of Chinese Integrative Medicine, 2010, 8(11): 1041-1047
[8] Tao Wang , Feng Qin. Effects of Chinese herbal medicine Xiaoyao Powder on monoamine neurotransmitters in hippocampus of rats with postpartum depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1075-1079
[9] Ying Xu , Chang-chun Zeng , Xiu-yu Cai , Rong-ping Guo , Guang Nie , Ying Jin. Chromaticity and optical spectrum colorimetry of the tongue color in different syndromes of primary hepatic carcinoma. Journal of Chinese Integrative Medicine, 2012, 10(11): 1263-1271
[10] Xiang-ying Mao , Qin Bian , Zi-yin Shen. Analysis of the osteogenetic effects exerted on mesenchymal stem cell strain C3H10T1/2 by icariin via MAPK signaling pathway in vitro. Journal of Chinese Integrative Medicine, 2012, 10(11): 1272-1278