Antitubercular agents,Isoniazid,Rifampicin,Pyrazinamide,Oxidative stress,Complementary therapies," /> Antitubercular agents,Isoniazid,Rifampicin,Pyrazinamide,Oxidative stress,Complementary therapies,"/> Clinical and experimental research in antituberculosis drug-induced hepatotoxicity: A review
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Journal of Integrative Medicine ›› 2017, Vol. 15 ›› Issue (1): 27-36.doi: 10.1016/S2095-4964(17)60319-4

• Review • Previous Articles     Next Articles

Clinical and experimental research in antituberculosis drug-induced hepatotoxicity: A review

Udhaya Lavinya Baskaran, Evan Prince Sabina   

  1. School of Biosciences and Technology, VIT University, Vellore-632014, Tamilnadu, India
  • Received:2016-06-30 Accepted:2016-09-27 Online:2017-01-15 Published:2017-01-15
  • Contact: Evan Prince Sabina; E-mail: eps674@gmail.com

Drug-induced liver injury is the common adverse effect seen in patients receiving antituberculosis drugs (ATDs). There are several risk factors associated with the development of hepatotoxicity in such patients. Though there have been appreciable efforts taken by carrying out studies investigating the efficacy of several natural and synthetic compounds in minimising this effect, the only choice available for clinicians is withdrawal of drugs. This review would give a precise idea of ATD-induced hepatotoxicity, its underlying mechanisms and alternative therapies for the same.

Key words: Antitubercular agents, Isoniazid, Rifampicin, Pyrazinamide, Oxidative stress, Complementary therapies

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