清肾颗粒对慢性肾功能衰竭急剧加重湿热证患者血清白细胞介素8和18水平影响的随机对照临床研究

doi:10.3736/jcim20100405

Abstract

Background

Dampness-heat syndrome is a major syndrome type in patients with a sharp deterioration of chronic renal failure (CRF). Qingshen Decoction, a compound traditional Chinese herbal medicine, could relieve the clinical symptoms of CRF patients, and was considered to have a certain reversal effect on rapid deterioration of renal function.
Objective

To observe the changes of serum interleukin-8 (IL-8) and IL-18 levels in CRF patients with a sharp deterioration and dampness-heat syndrome, and to explore the curative efficacy of Qingshen Granule.Design, setting, participants and interventions: Sixty CRF patients with a sharp deterioration and dampness-heat syndrome from Department of Nephrology, the First Affiliated Hospital of Anhui College of Traditional Chinese Medicine, were randomly divided into treatment group (30 cases) and control group (30 cases), with another 20 healthy individuals as normal control. The patients in the treatment and control groups were all treated with Jiedu Xiezhuo Ⅱ, a compound traditional Chinese herbal medicine, given as retention enema. Qingshen Granule was additionally administered to the patients in the treatment group with 1 dosage each time and 3 times a day. The treatment course was one month.Main outcome measures: The levels of serum IL-8 and IL-18 in the normal individuals and before and after treatment in the treatment and control groups were detected.
Results

The total response rates of treatment group in clinical efficacy assessment and assessment of syndrome of traditional Chinese medicine (86.67% and 86.67%) were higher than those of the control group (56.67% and 60%), and there were significant differences between the two groups (P<0.05). The levels of serum IL-8 and IL-18 in CRF patients before treatment were obviously higher than those in the healthy individuals (P<0.01), and there were no differences in the levels of IL-8 and IL-18 before treatment between the treatment group and control group (P>0.05). After one-month treatment, the levels of serum IL-8 and IL-18 were markedly decreased in the two groups (P<0.01), and the levels of serum IL-8 and IL-18 in the treatment group were markedly lower than those in the control group (P<0.05). There were differences in decreased degrees of IL-8 and IL-18 levels between the two groups (P<0.05).
Conclusion

CRF patients with a sharp deterioration and dampness-heat syndrome have high serum IL-8 and IL-18 levels. Qingshen Granule can reduce the levels of serum IL-8 and IL-18, and improve the renal function and ameliorate the clinical symptoms.

Key words: Chronic renal failure, Dampness-heat, Interleukin-8, Interleukin-18, Chinese herbal drug, Randomized controlled trial

Fei Wang, Yi-ping Wang, Dong Wang, Wan Cheng, Shun-jin Hu, Yong Lu, Ling Liu. Effects of Qingshen Granule on serum interleukin-8 and -18 levels in patients with a sharp deterioration of chronic renal failure and dampness-heat syndrome: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2010, 8(4): 328-331.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20100405

http://www.jcimjournal.com/EN/Y2010/V8/I4/328

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References 7

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Group	n	IL-8	IL-18
Normal
Before treatment	20	42.45±5.83	76.12±9.73
After treatment	20	—	—
Control
Before treatment	30	116.34±20.72^△△	249.14±69.94^△△
After treatment	30	105.63±23.05^**	227.48±71.47^**
Difference	30	10.75±2.31	21.66±1.52
Treatment
Before treatment	30	115.63±20.12^△△	247.18±68.04^△△
After treatment	30	93.24±18.36^**▲	193.78±57.22^**▲
Difference	30	22.42±1.82^▲	53.4±11.81^▲

Group	n	Serum creatinine (mol/L)	Glomerular filtration rate (mL/min)
Control
Before treatment	30	412.08±195.49	35.41±24.62
After treatment	30	390.21±191.30	43.34±25.74
Difference	30	22.84±4.10	0.94±1.03
Treatment
Before treatment	30	411.30±274.61	34.45±21.29
After treatment	30	293.72±197.62^**▲▲	60.47±25.76^**▲▲
Difference	30	117.42±76.84^▲▲	26.01±4.42^▲▲

Effects of Qingshen Granule on serum interleukin-8 and -18 levels in patients with a sharp deterioration of chronic renal failure and dampness-heat syndrome: A randomized controlled trial

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