补肾疏肝方对神经性厌食应激模型大鼠下丘脑-垂体-卵巢轴功能的影响

doi:10.3736/jcim20101010

Abstract

Objective

To investigate the effects of Bushen Shugan Recipe (BSSGR), a compound traditional Chinese herbal medicine, in regulating the hypothalamus-pituitary-ovarian axis (HPOA) in a rat model of stress-induced anorexia.
Methods

Anorexia was induced in rats by the methods of separation, diet restriction and constraint. Rats were divided into 4 groups randomly: control group, untreated group, sham-operated group and BSSGR group. After the experiments, body weights and oestrous cycles of the 4 groups were compared. The levels of serum estradiol (E2), hypophysis luteotrophic hormone (LH), hypophysis follicle stimulating hormone (FSH) and hypothalamus β-endorphin (β-EP) were detected by radioimmunoassay. The level of serum corticosterone (CORT) was detected by enzyme-linked immunosorbent assay.

Results

Body weight of BSSGR group was significantly increased in comparison with sham-operated group(P<0.01); the oestrous cycle disordering rate was higher than those of the untreated group and sham-operated group; hypophysis LH and serum E2 were obviously increased in comparison with untreated group (P<0.05); hypothalamus β-EP was obviously decreased in comparison with sham-operated group (P<0.05); serum CORT was obviously decreased in comparison with untreated group (P<0.05）, and significantly decreased in comparison with sham-operated group (P<0.01).
Conclusion

BSSGR increased hypophysis LH and serum E2, and decreased serum CORT and hypothalamus β-EP in rats with stress-induced anorexia.

Key words: Compounds(TCD), Anorexia nervosa, Stress models, Hypothalamus-pituitary-ovarian axis

WX Hu, CQ Yu, DX Zhai, J Han, DY Zhang. Effects of Chinese herbal medicine Bushen Shugan Recipe in regulating the hypothalamus-pituitary-ovarian axis in a rat model of stress-induced anorexia. Journal of Chinese Integrative Medicine, 2010, 8(10): 974-978.

/ / Recommend

Add to citation manager EndNote| Reference Manager|ProCite|BibTeX|RefWorks

URL: http://www.jcimjournal.com/EN/10.3736/jcim20101010

http://www.jcimjournal.com/EN/Y2010/V8/I10/974

TrendMD

Figures/Tables 3

Table 1

Table 2

Table 3

References 13

[1]	Zhao P, Mao FQ, Li ZT . Investigation of clinical feature and psychiatric intervention of anorexia nervosa[J]. Guo Ji Zhong Hua Shen Jing Jing Shen Yi Xue Za Zhi, 2005,6(3):201-203
	赵朋, 毛富强, 李振涛 . 神经性厌食症的临床特点及精神科干预对策[J]. 国际中华神经精神医学杂志, 2005,6(3):201-203
[2]	Liu CH, Dou JT, Lu JM . The changes of endocrine function in patients with anorexia nervosa[J]. Lin Chuang Nei Ke Za Zhi, 2002,19(6):449-450 doi: 10.3969/j.issn.1001-9057.2002.06.018
	吕朝晖, 窦京涛, 陆菊明 . 神经性厌食患者内分泌功能的改变[J]. 临床内科杂志, 2002,19(6):449-450 doi: 10.3969/j.issn.1001-9057.2002.06.018
[3]	Shimizu N, Oomura Y, Kai Y . Stress-induced anorexia in rats mediated by serotonergic mechanisms in the hypothalamus[J]. Physiol Behav, 1989,46(5):835-841 doi: 10.1016/0031-9384(89)90045-0 pmid: 2628995
[4]	Wang ZZ, Yu CQ . Effects of Bushen Huayu Qutan Recipe on local ovarian factors in androgen-sterilized rats[J]. J Chin Integr Med, 2008,6(4):361-365
	王针织, 俞超芹 . 补肾化瘀祛痰方对雄激素致不孕大鼠卵巢局部调控因子的影响[J]. 中西医结合学报, 2008,6(4):361-365
[5]	Zhang S, Wang X, Wei XB, Tan JH . Observation on the vaginal smear photographs for each stage of estrus cycle in rats[J]. Dong Wu Yi Xue Jin Zhan, 2006,27(2):69-72 doi: 10.3969/j.issn.1007-5038.2006.02.018
	张森, 王新, 韦旭斌, 谭建华 . 大鼠发情周期各阶段的阴道细胞变化观察[J]. 动物医学进展, 2006,27(2):69-72 doi: 10.3969/j.issn.1007-5038.2006.02.018
[6]	Wang JH, Wang MZ, Ouyang D, Wu QH . Effects of flavonoids from Semen Cuscutae on changes of β-EP in hypothalamuses and FSH and LH in anterior pituitaries in female rats exposed to psychologic stress[J]. Zhong Yao Cai, 2002,25(12):886-888 doi: 10.3321/j.issn:1001-4454.2002.12.015
	王建红, 王敏璋, 欧阳栋, 伍庆华 . 菟丝子黄酮对心理应激雌性大鼠下丘脑β-EP与腺垂体FSH、LH的影响[J]. 中药材, 2002,25(12):886-888 doi: 10.3321/j.issn:1001-4454.2002.12.015
[7]	Yen SS, Jaffe RB, Barbieri RL. Reproductive Endocrinology[M]. Beijing: Science Press,2001: 546-550
	Yen SS, Jaffe RB, Barbieri RL. Reproductive Endocrinology[M]. 北京: 科学出版社,2001: 546-550
[8]	Yang JB, Li XH . On the relationship between β-endorphin and female genital endocrine[J]. Shanxi Zhong Yi Xue Yuan Xue Bao, 2004,27(3):9-11
	杨鉴冰, 李小花 . β-内啡肽与女性生殖内分泌的关系探讨[J]. 陕西中医学院学报, 2004,27(3):9-11
[9]	Hou ZM, Wang YR . Application of tonifying kidney in gynecology[J]. Nei Meng Gu Zhong Yi Yao, 2008,( 2):20-21 doi: 10.3969/j.issn.1006-0979.2008.02.016
	侯志明, 王艳荣 . 补肾法在妇科中的运用[J]. 内蒙古中医药, 2008,( 2):20-21 doi: 10.3969/j.issn.1006-0979.2008.02.016
[10]	Ge JL . Examples of soothing liver in gynecology[J]. Jiangsu Zhong Yi Yao, 2005,26(10):33-34 doi: 10.3969/j.issn.1672-397X.2005.10.019
	阁继兰 . 疏肝论治妇科病举隅[J]. 江苏中医药, 2005,26(10):33-34 doi: 10.3969/j.issn.1672-397X.2005.10.019
[11]	Saketos M, Sharma N, Santoro NF . Suppression of the hypothalamic-pituitary-ovarian axis in normal women by glucocorticoids[J]. Biol Reprod, 1993,49(6):1270-1276 doi: 10.1095/biolreprod49.6.1270
[12]	Breen KM, Billings HJ, Wagenmaker ER, Wessinger EW, Karsch FJ . Endocrine basis for disruptive effects of cortisol on preovulatory events[J]. Endocrinology, 2005,146(4):2107-2115 doi: 10.1210/en.2004-1457 pmid: 15625239
[13]	Breen KM, Karsch FJ . Does cortisol inhibit pulsatile luteinizing hormone secretion at the hypothalamic or pituitary level?[J]. Endocrinology, 2004,145(2):692-698 doi: 10.1210/en.2003-1114

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

Comments

Recommended 10

[1]	Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. An explanation on "guiding principles of clinical research on mild cognitive impairment (protocol)". Journal of Chinese Integrative Medicine, 2008, 6(1): 15-21
[2]	Yi-ting He, Qing-lin Zha, Jian-ping Yu, Yong Tan, Cheng Lu, Ai-ping Lv. Principal factor analysis of symptoms of rheumatoid arthritis and their correlations with efficacy of traditional Chinese medicine and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 32-36
[3]	Jun Cai, Hua Wang, Sheng Zhou, Bin Wu, Hua-rong Song, Zheng-rong Xuan. Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(1): 37-40
[4]	Wei Zhang, Xiang-feng Lu, Xiao-mei Zhang, Jian-jun Wu, Liang-duo Jiang. A rat model of pulmonary fibrosis induced by infusing bleomycin quickly through tracheal intubation. Journal of Chinese Integrative Medicine, 2008, 6(1): 60-67
[5]	A-gao Zhou, Yong Zhang, Gang Kui, De-Yun Kong, Hai-liang Ge, Qiu-hua Ren, Jia-rong Dong, Sheng Hong, Xu-ming Mao, Yin Wang, Hui-zheng Zhang, Shu-jun Wang. Influence of traditional Chinese compound recipes with different efficacy on body weight, tumor weight and immune function in H₂₂ cancer-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 77-82
[6]	Guo-hong Yuan, Xiao-jing Pang, He-chao Ma. Synergic effects of Danggui Buxue Decoction in reducing toxicity of cytoxan in tumor-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 83-88
[7]	Li Zhou, Hong-xing Zhang, Ling-guang Liu, Wen-jun Wan. Effect of electro-acupuncture at Fenglong (GV 16) on nitric oxide and endothelin in rats with hyperlipidemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 89-92
[8]	Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. Guiding principles of clinical research on mild cognitive impairment (protocol). Journal of Chinese Integrative Medicine, 2008, 6(1): 9-14
[9]	Xin-jun Wang, Ling-ling Wang . A mechanism of endogenous opioid peptides for rapid onset of acupuncture effect in treatment of depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1014-1017
[10]	Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022

Effects of Chinese herbal medicine Bushen Shugan Recipe in regulating the hypothalamus-pituitary-ovarian axis in a rat model of stress-induced anorexia

RichHTML

PDF (PC)

Cited

Like

Abstract

Cite this article

Share this article