胃癌中医证型与临床相关因素的多因素分析

doi:10.3736/jcim20070506

Abstract

Objective: The research is aimed at investigating the developing rule and the relationship between syndrome differentiation in traditional Chinese Medicine (TCM) and clinical factors of gastric cancer so as to guide clinical work and indicate prognosis.Methods: We collected the medical records and the information of four diagnostic methods of 325 cases of gastric cancer sufferers in the way of clinical epidemiological survey, and divided them into 6 syndromes including dysfunction of spleen, disharmony of liver and stomach, blood stagnation in stomach, yin deficiency of stomach, phlegm dampness stagnation and deficiency of both qi and blood. Then we used logistic regression analysis to analyze the relationship between syndrome differentiation and clinical-related factors such as age, gender, Karnofsky score and clinical stage, etc.Results: The syndrome spleen dysfunction is a dominant one among the syndromes of stomach cancer. Disharmony of liver and stomach always happens in early stage of stomach cancer and is frequently seen in women. Patients with syndrome of phlegm dampness stagnation or deficiency of both qi and blood have lower Karnofsky score and poorer living quality. Syndromes of blood stagnation in stomach and yin deficiency of stomach show no relationship with the clinical factors in this research.Conclusion: >Syndrome differentiation in TCM of gastric cancer is related to some clinical factors to a certain extent.

Key words: gastric cancer, traditional Chinese medicine, clinical factor, logistic regression analysis

CLC Number:

R735.2

Li Tao, Jin-kun Yang. Multifactor analysis of syndrome differentiation in traditional Chinese medicine and clinical correlative factors in gastric cancer. Journal of Chinese Integrative Medicine, 2007, 5(5): 510-513.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20070506

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References 8

[1]	中国抗癌协会. 新编常见恶性肿瘤诊治规范[M]. 北京: 中国协和医科大学出版社,1999 1-94
	Chinese Anti-cancer Association . New criteria for diagnosis and treatment of common malignant tumors[M]. Beijing: Beijing Union Medical University Press,1999 1-94
[2]	陶丽, 杨金坤 . 胃癌中医辨证分型的文献分析[J]. 中医药学刊, 2006,24(4):684-686
	Tao L, Yang JK . Analysis on the literature about syndrome differentiation of gastric cancer in traditional Chinese medicine[J]. Zhong Yi Yao Xue Kan, 2006,24(4):684-686
[3]	国家技术监督局. 中华人民共和国国家标准·中医临床诊疗术语证候部分[M]. 北京: 中国标准出版社,1997 1-38
	The State Bureau of Technology Supervision. National Standards of People's Republic of China: Syndrome part of terminology of traditional Chinese medicine clinical diagnosis and treatment[M]. Beijing: Standards Press of China,1997 1-38
[4]	中华人民共和国卫生部. 中药新药临床研究指导原则(第三辑). 1997: 78-81.
	Ministry of Health of the People's Republic of China. Guiding principle of clinical research on new drugs. Part 3. 1997: 78-81. Chinese.
[5]	上海市卫生局. 上海市中医病证诊疗常规(第2版)[M]. 上海: 上海中医药大学出版社, 2003,( 第2版):129-131
	Shanghai Municipal Health Bureau . Criteria for diagnosis and treatment of traditional Chinese medicine syndromes in Shanghai(2nd ed)[M]. Shanghai: Shanghai University of Traditional Chinese Medicine Press, 2003,( 2nd ed):129-131
[6]	中国中医研究院广安门医院. 中医诊疗常规[M]. 北京: 中医古籍出版社,1989 297-299
	Guang'anmen Hospital affiliated to China Academy of Traditional Chinese Medicine. Criteria for traditional Chinese medicine diagnosis and treatment[M]. Beijing: Publishing House of Ancient Books of Traditional Chinese Medicine,1989 297-299
[7]	邓铁涛, 郭振球 . 中医诊断学(第5版)[M]. 上海: 上海科学技术出版社,1984,(第5版):114- 117, 124-128
	Deng TT, Guo ZQ.Traditional Chinese medicine diagnostics( 5th ed) [M].Shanghai: Shanghai Scientific and Technical Publishers , 1984,( 5th ed):114- 117, 124-128
[8]	陶丽, 杨金坤 . 胃癌中医证型与临床相关因素的单因素分析[J]. 中西医结合学报, 2007,5(4):398-402
	Tao L, Yang JK . Univariate analysis of syndrome differentiation in traditional Chinese medicine and clinical correlative factors in gastric cancer[J]. Zhong Xi Yi Jie He Xue Bao, 2007,5(4):398-402

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Variable	B	Std. Error	Wald	Sig	Exp (B)
KPS score	–0.118	0.026	19.990	0.000	0.889
Suffering time	–0.135	0.450	0.090	0.764	0.874
Surgical mode	1.697	1.865	0.828	0.363	5.459
Course of chemotherapy	0.181	0.291	0.388	0.533	1.199
Metastasis	–5.700	3.177	3.220	0.073	0.003

Variable	B	Std. Error	Wald	Sig	Exp (B)
Sex	–0.834	0.419	3.958	0.047	0.434
Clinical stage	0.694	0.245	8.005	0.005	2.002
Surgical mode	14.797	3 035.240	0.000	0.996	2 668 188.125
Metastasis	13.238	3 762.011	0.000	0.997	561 166.319

Variable	B	Std. Error	Wald	Sig	Exp (B)
KPS score	0.045	0.087	0.266	0.606	1.046
Clinical stage	–1.385	1.631	0.721	0.396	0.250
Surgical mode	–0.121	20 943.250	0.000	1.000	0.886
Suffering time	16.063	5 551.222	0.000	0.998	9 461 739
Metastasis	19.607	34 756.010	0.000	1.000	330 000 000

Variable	B	Std. Error	Wald	Sig	Exp (B)
KPS score	0.031	0.015	4.180	0.041	1.032
Clinical stage	–0.295	0.219	1.810	0.178	0.745

Variable	B	Std. Error	Wald	Sig	Exp (B)
KPS score	0.240	0.101	5.640	0.018	1.272
Clinical stage	–1.388	5.375	0.067	0.796	0.249
Surgical mode	–5.070	4.178	1.473	0.225	0.006
Course of chemotherapy	–1.432	2.044	0.491	0.483	0.239
Suffering time	13.838	5 036.177	0.000	0.998	1 022 294
Relapse	0.052	35.530	0.000	0.999	1.053
Metastasis	7.950	8.065	0.972	0.324	2 835.003

Multifactor analysis of syndrome differentiation in traditional Chinese medicine and clinical correlative factors in gastric cancer

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