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Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (5): 510-513.doi: 10.3736/jcim20070506

Special Issue: Traditional Chinese Medicine

• Original Clinical Research • Previous Articles     Next Articles

Multifactor analysis of syndrome differentiation in traditional Chinese medicine and clinical correlative factors in gastric cancer

Li Tao, Jin-kun Yang   

  1. First Department of Tumor , Longhua Hospital ,Shanghai University of Traditional Chinese Medicine , Shanghai 200032,China
  • Online:2007-09-20 Published:2007-09-15

Objective: The research is aimed at investigating the developing rule and the relationship between syndrome differentiation in traditional Chinese Medicine (TCM) and clinical factors of gastric cancer so as to guide clinical work and indicate prognosis.Methods: We collected the medical records and the information of four diagnostic methods of 325 cases of gastric cancer sufferers in the way of clinical epidemiological survey, and divided them into 6 syndromes including dysfunction of spleen, disharmony of liver and stomach, blood stagnation in stomach, yin deficiency of stomach, phlegm dampness stagnation and deficiency of both qi and blood. Then we used logistic regression analysis to analyze the relationship between syndrome differentiation and clinical-related factors such as age, gender, Karnofsky score and clinical stage, etc.Results: The syndrome spleen dysfunction is a dominant one among the syndromes of stomach cancer. Disharmony of liver and stomach always happens in early stage of stomach cancer and is frequently seen in women. Patients with syndrome of phlegm dampness stagnation or deficiency of both qi and blood have lower Karnofsky score and poorer living quality. Syndromes of blood stagnation in stomach and yin deficiency of stomach show no relationship with the clinical factors in this research.Conclusion: >Syndrome differentiation in TCM of gastric cancer is related to some clinical factors to a certain extent.

Key words: gastric cancer, traditional Chinese medicine, clinical factor, logistic regression analysis

CLC Number: 

  • R735.2

Table 1

Logistic regression analysis of dysfunction of spleen"

Variable B Std. Error Wald Sig Exp (B)
KPS score –0.118 0.026 19.990 0.000 0.889
Suffering time –0.135 0.450 0.090 0.764 0.874
Surgical mode 1.697 1.865 0.828 0.363 5.459
Course of chemotherapy 0.181 0.291 0.388 0.533 1.199
Metastasis –5.700 3.177 3.220 0.073 0.003

Table 2

Logistic regression analysis of disharmony of liver and stomach"

Variable B Std. Error Wald Sig Exp (B)
Sex –0.834 0.419 3.958 0.047 0.434
Clinical stage 0.694 0.245 8.005 0.005 2.002
Surgical mode 14.797 3 035.240 0.000 0.996 2 668 188.125
Metastasis 13.238 3 762.011 0.000 0.997 561 166.319

Table 3

Logistic regression analysis of blood stagnation in stomach"

Variable B Std. Error Wald Sig Exp (B)
KPS score 0.045 0.087 0.266 0.606 1.046
Clinical stage –1.385 1.631 0.721 0.396 0.250
Surgical mode –0.121 20 943.250 0.000 1.000 0.886
Suffering time 16.063 5 551.222 0.000 0.998 9 461 739
Metastasis 19.607 34 756.010 0.000 1.000 330 000 000

Table 4

Logistic regression analysis of phlegm dampness stagnation"

Variable B Std. Error Wald Sig Exp (B)
KPS score 0.031 0.015 4.180 0.041 1.032
Clinical stage –0.295 0.219 1.810 0.178 0.745

Table 5

Logistic regression analysis of deficiency of qi and blood"

Variable B Std. Error Wald Sig Exp (B)
KPS score 0.240 0.101 5.640 0.018 1.272
Clinical stage –1.388 5.375 0.067 0.796 0.249
Surgical mode –5.070 4.178 1.473 0.225 0.006
Course of chemotherapy –1.432 2.044 0.491 0.483 0.239
Suffering time 13.838 5 036.177 0.000 0.998 1 022 294
Relapse 0.052 35.530 0.000 0.999 1.053
Metastasis 7.950 8.065 0.972 0.324 2 835.003
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