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Journal of Integrative Medicine ›› 2016, Vol. 14 ›› Issue (2): 84-99.doi: 10.1016/S2095-4964(16)60247-9

Special Issue: Natural Drug

• Review • Previous Articles     Next Articles

Health-promoting and disease-preventive potential of Trianthema portulacastrum Linn. (Gadabani)—An Indian medicinal and dietary plant

JasonYamakia,b, Kalyan C. NagulapalliVenkatac, AnimeshMandald, PiyaliBhattacharyyae, AnupamBishayeec   

  1. a Department of Pharmacy Practice, School of Pharmacy, Chapman University, Irvine, CA 92618, USA 
    b Hoag Memorial Hospital Presbyterian, Newport Beach, CA 92663, USA 
    c Department of Pharmaceutical Sciences, College of Pharmacy, Larkin Health Sciences Institute, Miami, FL 33169, USA 
    d Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH 44272, USA 
    e School of Health Sciences, University of Turabo, Gurabo, PR 00778, USA
  • Received:2015-09-25 Accepted:2016-01-10 Online:2016-03-15 Published:2016-03-15
  • Contact: Prof. Anupam Bishayee; E-mail: abishayee@ULarkin.org, abishayee@gmail.com

It is estimated that 80% of the world population depends on traditional medicine for primary healthcare need. Trianthema portulacastrum Linn. (family: Aizoaceae) is a small perennial weed found in the Americas, Africa, India, and other regions of the world. This plant is used extensively in Indian traditional medicines and is also consumed as a vegetable throughout Asia for its perceived health benefits. Phytochemical analysis of T. portulacastrum reveals the presence of alkaloids, flavonoids, terpenoids, saponins, and phenolic compounds. Emerging studies demonstrate that crude extracts as well as bioactive phytoconstituents of T. portulacastrum exhibit potent antioxidant, anti-infective, analgesic, and anti-inflammatory activities. A growing number of in vitro and in vivo studies demonstrate various biological and pharmacological activities, including prevention and amelioration of hepatotoxicity, nephrotoxicity, hyperglycemia, hyperlipidemia, infectious diseases and cancer. This review aims to present and analyze available literature to understand the full potential of T. portulacastrum in health promotion and disease prevention. Current limitations and future directions of research on this medicinal and dietary plant are also critically discussed.

Key words: Trianthema portulacastrum, Phytochemistry, Pharmacology, Health benefits, Review, Herbal medicine

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