Propolis,diabetes mellitus, type 2,Blood glucose,Insulin resistance," /> Propolis,diabetes mellitus, type 2,Blood glucose,Insulin resistance,"/> Effects of bee propolis supplementation on glycemic control, lipid profile and insulin resistance indices in patients with type 2 diabetes: A randomized, double-blind clinical trial
Search JIM Advanced Search

Journal of Integrative Medicine ›› 2017, Vol. 15 ›› Issue (2): 124-134.doi: 10.1016/S2095-4964(17)60315-7

• Research Article • Previous Articles     Next Articles

Effects of bee propolis supplementation on glycemic control, lipid profile and insulin resistance indices in patients with type 2 diabetes: A randomized, double-blind clinical trial

Nazli Samadia, Hassan Mozaffari-Khosravia,b, Masoud Rahmanianb,c, Mohsen Askarishahid   

  1. a Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 
    b Yazd Diabetic Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
    c Department of Internal Medicine, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
    d Department of Biostatistics and Epidemiology, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Received:2016-08-15 Accepted:2016-11-02 Online:2017-03-15 Published:2017-03-15
  • Contact: Hassan Mozaffari-Khosravi, PhD; E-mail:


 Propolis, a natural resinous substance made by bees from material extracted from plants, flowers and bee's wax, has shown great therapeutic effects and been widely used in food and drug industries. Recently, some researchers have studied the effect of this substance in the treatment of diabetes.


The purpose of this trial was to determine the effect of bee propolis on glycemic control, serum lipid profile and insulin resistance indices in patients with type 2 diabetes (T2D).

Design, Setting, Participants and Interventions

This randomized clinical trial involved 66 patients with T2D, which were randomly divided into two groups of intervention (IG) and placebo (PG). IG received 300 mg three times a day for a total of 900 mg/d of propolis pills, while PG received similar pills, lacking propolis, on the same schedule for 12 weeks.

Main Outcome Measures

Fasting blood glucose (FBG), hemoglobin A1c (HbA1c), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), serum insulin and insulin resistance indices were the main outcome measures.


The mean change in FBG between the IG ((17.76 ± 27.72) mg/dL decrease) and the PG ((6.48 ± 42.77) mg/dL increase) was significantly different (P = 0.01). Change in mean HbA1c had a similar pattern to FBG. The mean change in TC between the IG ((5.16 ± 43.80) mg/dL increase) and the PG ((28.9 ± 27.4) mg/dL increase) was also significantly different (P = 0.01), showing the protective role of propolis against the increase in TC. The change in mean LDL was similar to mean TC. There was no significant difference in other lipids or insulin resistance indices between the two groups.


Based on this study, the daily intake of 900 mg of bee propolis supplement for 12 weeks results in improvement of glycemic and some serum lipid levels in patients with T2D.

Trial registration

This study is registered on the website of Iranian Ministry of Health ( with proprietary code of IRCT2014080218659N1.

Key words: Propolis, diabetes mellitus, type 2, Blood glucose, Insulin resistance

1 American Diabetes Association.Diagnosis and classifi cation of diabetes mellitus.Diabetes Care. 2014; 37(Suppl 1): S81-S90.
2 Craig ME, Hattersley A, Donaghue KC.Definition, epidemiology and classifi cation of diabetes in children and adolescents.Pediatric Diabetes. 2009; 10(Suppl 12): 3-12.
3 Galtier F.Definition, epidemiology, risk factors.Diabetes Metab. 2010; 36(6): 628-651.
4 Melmed S, Polonsky KS, Larsen PR, Kronenberg HM.Williams textbook of endocrinology. 13th ed. Philadelphia: Elsevier Health Sciences. 2015.
5 Shi Y, Hu FB.The global implications of diabetes and cancer.Lancet. 2014; 383(9933): 1947-1948.
6 Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, et al.Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.Lancet. 2012; 380(9859): 2163-2196.
7 Wild S, Roglic G, Green A, Sicree R, King H.Global prevalence of diabetes estimates for the year 2000 and projections for 2030.Diabetes Care. 2004; 27(5): 1047-1053.
8 Toreti VC, Sato HH, Pastore GM, Park YK.Recent progress of propolis for its biological and chemical compositions and its botanical origin.Evid Based Complement Alternat Med. 2013; 2013: 697390.
9 Búfalo MC, Candeias JM, Sforcin JM.In vitro cytotoxic effect of Brazilian green propolis on human laryngeal epidermoid carcinoma (HEp-2) cells. Evid Based Complement Alternat Med. 2009; 6(4): 483-487.
10 Castaldo S, Capasso F.Propolis, an old remedy used in modern medicine.Fitoterapia. 2002; 73(Suppl 1): S1-S6.
11 Mizrahi A, Lensky Y.Bee products: properties, applications, and apitherapy. New York: Springer Science & Business Media. 1997.
12 Ghisalberti EL.Propolis: a review.Bee World. 1979; 60(2): 59-84.
13 Burdock GA.Review of the biological properties and toxicity of bee propolis (propolis). Food Chem Toxicol.1998; 36(4): 347-363.
14 Pietta PG, Gardana C, Pietta AM.Analytical methods for quality control of propolis.Fitoterapia. 2002; 73(Suppl 1): S7-S20.
15 Walker P, Crane E.Constituents of propolis.Apidologie. 1987; 18(4): 327-334.
16 Bueno-Silva B, Alencar SM, Koo H, Ikegaki M, Silva GV, Napimoga MH, Rosalen PL.Anti-inflammatory and antimicrobial evaluation of neovestitol and vestitol isolated from Brazilian red propolis.J Agric Food Chem. 2013; 61(19): 4546-4550.
17 Lopes AA, Ferreira TS, Nesi RT, Lanzetti M, Pires KMP, Silva AM, Borges RM, Silva AJR, Valença SS, Porto LC.Antioxidant action of propolis on mouse lungs exposed to short-term cigarette smoke.Bioorg Med Chem. 2013; 21(24): 7570-7577.
18 Martin LFT, Rocha EM, Garcia SB, Paula JS.Topical Brazilian propolis improves corneal wound healing and inflammation in rats following alkali burns.BMC Complement Altern Med. 2013; 13(1): 337.
19 Machado JL, Assunção AK, da Silva MC, Dos Reis AS, Costa GC, Arruda Dde S, Rocha BA, Vaz MM, Paes AM, Guerra RN, Berretta AA, do Nascimento FR. Brazilian green propolis: anti-inflammatory property by an immunomodulatory activity.Evid Based Complement Alternat Med. 2012; 2012: 157652.
20 Verma MK, Pandey RK, Khanna R, Agarwal J.The antimicrobial effectiveness of 25% propolis extract in root canal irrigation of primary teeth.J Indian Soc Pedod Prev Dent. 2014; 32(2): 120.
21 Dota KF, Consolaro ME, Svidzinski TI, Bruschi ML.Antifungal activity of Brazilian propolis microparticles against yeasts isolated from vulvovaginal candidiasis.Evid Based Complement Alternat Med. 2011; 2011: 201953.
22 Silici S, Koç NA, Ayangil D, Çankaya S.Antifungal activities of propolis collected by different races of honeybees against yeasts isolated from patients with superfi cial mycoses. J Pharmacol Sci.2005; 99(1): 39-44.
23 Fuliang HU, Hepburn H, Xuan H, Chen M, Daya SE, Radloff S.Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus.Pharmacol Res. 2005; 51(2): 147-152.
24 Campos JF, dos Santos UP, Macorini LFB, de Melo AMMF, Balestieri JBP, Paredes-Gamero EJ, Cardoso CAL, de Picoli Souza K, dos Santos EL. Antimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae).Food Chem Toxicol. 2014; 65: 374-380.
25 Cinegaglia NC, Bersano PRO, Araújo MJAM, Búfalo MC, Sforcin JM.Anticancer effects of geopropolis produced by stingless bees on canine osteosarcoma cellsin vitro. Evid Based Complement Alternat Med. 2013; 2013: 737386.
26 Omene C, Kalac M, Wu J, Marchi E, Frenkel K, O’Connor OA. Propolis and its active component, caffeic acid phenethyl ester (CAPE), modulate breast cancer therapeutic targets via an epigenetically mediated mechanism of action.J Cancer Sci Ther. 2013; 5(10): 334-342.
27 Fan Y, Ma L, Zhang W, Wang J, Chen Y, Gao Y, Feng W, Zhong L, Song X.The design of propolis flavone microemulsion and its effect on enhancing the immunity and antioxidant activity in mice.Int J Biol Macromol. 2014; 65: 200-207.
28 Choudhari MK, Haghniaz R, Rajwade JM, Paknikar KM.Anticancer activity of Indian stingless bee propolis: an in vitro study. Evid Based Complement Alternat Med. 2013; 2013: 928280.
29 Szliszka E, Krol W.Polyphenols isolated from propolis augment TRAIL-induced apoptosis in cancer cells.Evid Based Complement Alternat Med. 2013; 2013: 731940.
30 Missima F, Sforcin JM.Green Brazilian propolis action on macrophages and lymphoid organs of chronically stressed mice. Evid Based Complement Alternat Med. 2008; 5(1): 71-75.
31 Orsatti CL, Missima F, Pagliarone AC, Bachiega TF, Búfalo MC, Araújo JP Jr, Sforcin JM.Propolis immunomodulatory actionin vivo on Toll-like receptors 2 and 4 expression and on pro-inflammatory cytokines production in mice. Phytother Res. 2010; 24(8): 1141-1146.
32 Maruyama H, Sumitou Y, Sakamoto T, Araki Y, Hara H.Antihypertensive effects of flavonoids isolated from Brazilian green propolis in spontaneously hypertensive rats.Biol Pharm Bull. 2009; 32(7): 1244-1250.
33 Mishima S, Yoshida C, Akino S, Sakamoto T.Antihypertensive effects of Brazilian propolis: identification of caffeoylquinic acids as constituents involved in the hypotension in spontaneously hypertensive rats.Biol Pharm Bull. 2005; 28(10): 1909-1914.
34 Kolankaya D, Selmanoǧlu G, Sorkun K, Salih B.Protective effects of Turkish propolis on alcohol-induced serum lipid changes and liver injury in male rats.Food Chem. 2002; 78(2): 213-217.
35 Tan-No K, Nakajima T, Shoji T, Nakagawasai O, Niijima F, Ishikawa M, Endo Y, Sato T, Satoh S, Tadano T.Antiinfl ammatory effect of propolis through inhibition of nitric oxide production on carrageenin-induced mouse paw edema.Biol Pharm Bull. 2006; 29(1): 96-99.
36 Hoşnuter M, Gürel A, Babucçu O, Armutcu F, Kargi E, Işikdemir A.The effect of CAPE on lipid peroxidation and nitric oxide levels in the plasma of rats following thermal injury.Burns. 2004; 30(2): 121-125.
37 Silva V, Genta G, Möller MN, Masner M, Thomson L, Romero N, Radi R, Fernandes DC, Laurindo FR, Heinzen H, Fierro W, Denicola A.Antioxidant activity of uruguayan propolis.In vitro and cellular assays. J Agric Food Chem. 2011; 59(12): 6430-6437.
38 Jasprica I, Mornar A, Debeljak Z, Smolcić-Bubalo A, Medić-Sarić M, Mayer L, Romić Z, Bućan K, Balog T, Sobocanec S, Sverko V.In vivo study of propolis supplementation effects on antioxidative status and red blood cells. J Ethnopharmacol. 2007; 110(3): 548-554.
39 Zhao JQ, Wen YF, Bhadauria M, Nirala SK, Sharma A, Shrivastava S, Shukla S, Agrawal OP, Mathur R.Protective effects of propolis on inorganic mercury induced oxidative stress in mice.Indian J Exp Biol. 2009; 47(4): 264-269.
40 Alyane M, Kebsa L, Boussenane H, Rouibah H, Lahouel M.Cardioprotective effects and mechanism of action of polyphenols extracted from propolis against doxorubicin toxicity.Pak J Pharm Sci. 2008; 21(3): 201-209.
41 Norata GD, Marchesi P, Passamonti S, Pirillo A, Violi F, Catapano AL.Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice.Atherosclerosis. 2007; 191(2): 265-271.
42 Grassi D, Aggio A, Onori L, Croce G, Tiberti S, Ferri C, Ferri L, Desideri G.Tea, flavonoids, and nitric oxidemediated vascular reactivity.J Nutr. 2008; 138(8): 1554S-1560S.
43 Gorinstein S, Leontowicz H, Leontowicz M, Jesion I, Namiesnik J, Drzewiecki J, Park YS, Ham KS, Giordani E, Trakhtenberg S.Influence of two cultivars of persimmon on atherosclerosis indices in rats fed cholesterol-containing diets: investigationin vitro and in vivo. Nutrition. 2011; 27(7-8): 838-846.
44 Tosi B, Donini A, Romagnoli C, Bruni A.Antimicrobial activity of some commercial extracts of propolis prepared with different solvents.Phytother Res. 1996; 10(4): 335-336.
45 Park YK, Koo MH, Abreu JA, Ikegaki M, Cury JA, Rosalen PL.Antimicrobial activity of propolis on oral microorganisms.Curr Microbiol. 1998; 36(1): 24-28.
46 Rossi A, Longo R, Russo A, Borrelli F, Sautebin L.The role of the phenethyl ester of caffeic acid (CAPE) in the inhibition of rat lung cyclooxygenase activity by propolis.Fitoterapia. 2002; 73(Suppl 1): S30-S37.
47 Lee YJ, Kuo HC, Chu CY, Wang CJ, Lin WC, Tseng TH.Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells. Biochem Pharmacol.2003; 66(12): 2281-2289.
48 Attia YA, Al-Hamid AEA, Ibrahim MS, Al-Harthi MA, Bovera F, Elnaggar AS.Productive performance, biochemical and hematological traits of broiler chickens supplemented with propolis, bee pollen, and mannan oligosaccharides continuously or intermittently.Livest Sci. 2014; 164(6): 87-95.
49 Attia YA, Bovera F, El-Tahawy WS, El-Hanoun AM, Al-Harthi MA, Habiba HI.Productive and reproductive performance of rabbits does as affected by bee pollen and/ or propolis, inulin and/or mannan-oligosaccharides.World Rabbit Sci. 2015; 23(4): 273-282.
50 Li Y, Chen M, Xuan H, Hu F.Effects of encapsulated propolis on blood glycemic control, lipid metabolism, and insulin resistance in type 2 diabetes mellitus rats.Evid Based Complement Alternat Med. 2012; 2012: 981896.
51 Abo-Salem OM, El-Edel RH, Harisa GE, El-Halawany N, Ghonaim MM.Experimental diabetic nephropathy can be prevented by propolis: effect on metabolic disturbances and renal oxidative parameters.Pak J Pharm Sci. 2009; 22(2): 205-210.
52 Kang LJ, Lee HB, Bae HJ, Lee SG.Antidiabetic effect of propolis: reduction of expression of glucose-6-phosphatase through inhibition of Y279 and Y216 autophosphorylation of GSK-3α/β in HepG2 cells.Phytother Res. 2010; 24(10): 1554-1561.
53 Ueda M, Hayashibara K, Ashida H.Propolis extract promotes translocation of glucose transporter 4 and glucose uptake through both PI3K-and AMPK-dependent pathways in skeletal muscle.Biofactors. 2013; 39(4): 457-466.
54 Kitamura H, Naoe Y, Kimura S, Miyamoto T, Okamoto S, Toda C, Shimamoto Y, Iwanaga T, Miyoshi I.Beneficial effects of Brazilian propolis on type 2 diabetes in ob/ob mice: possible involvement of immune cells in mesenteric adipose tissue.Adipocyte. 2013; 2(4): 227-236.
55 Zhu W, Chen M, Shou Q, Li Y, Hu F.Biological activities of Chinese propolis and Brazilian propolis on streptozotocininduced type 1 diabetes mellitus in rats.Evid Based Complement Alternat Med. 2011; 2011: 468529.
56 Al-Hariri M, Eldin TG, Abu-Hozaifa B, Elnour A.Glycemic control and anti-osteopathic effect of propolis in diabetic rats.Diabetes Metab Syndr Obes. 2011; 4: 377-384.
57 Zamami Y, Fujiwara H, Hosoda M, Hino H, Hirai K, Okamoto K, Jin X, Takatori S, Doi-Takaki S, Kawasaki H. Ameliorative effect of propolis on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Yakugaku Zasshi. 2010; 130(6): 833-840. Japanese with abstract in English.
58 Tang HW, Chan CH, Lin YT, Huang HY.Anti-diabetic effects of propolis in high fat diet fed-streptozotocininduced type 2 diabetic rat.FASEB J. 2015; 29(Suppl 1): 756-757.
59 Murata K, Yatsunami K, Fukuda E, Onodera S, Mizukami O, Hoshino G, Kamei T.Antihyperglycemic effects of propolis mixed with mulberry leaf extract on patients with type 2 diabetes.Altern Ther Health Med. 2004; 10(3): 78-79.
60 Fukuda T, Fukui M, Tanaka M, Senmaru T, Iwase H, Yamazaki M, Aoi W, Inui T, Nakamura N, Marunaka Y.Effect of Brazilian green propolis in patients with type 2 diabetes: a double-blind randomized placebo-controlled study.Biomed Rep. 2015; 3(3): 355-360.
61 Friedwald W, Leve R, Fredrichson D.Estimation of concentration of low density lipoproteins separated by three different methods.Clin Chem. 1972; 18: 499-502.
62 62 Diabetes Trials Unit, University of Oxford. HOMA Calculator v2.2. [2015-08-30]. homacalculator/.
63 Borai A, Livingstone C, Kaddam I, Ferns G.Selection of the appropriate method for the assessment of insulin resistance.BMC Med Res Methodol. 2011; 11: 158.
[1] Witoo Dilokthornsakul, Ramanya Kosiyaporn, Rattanamanee Wuttipongwaragon, Piyameth Dilokthornsakul. Potential effects of propolis and honey in COVID-19 prevention and treatment: A systematic review of in silico and clinical studies. Journal of Integrative Medicine, 2022, 20(2): 114-125.
[2] Pinar Tatli Seven, Ismail Seven, Selcan Karakus, Seda Iflazoglu Mutlu, Seyma Ozer Kaya, Gozde Arkali, Merve Ilgar, Ezgi Tan, Yesim Muge Sahin, Deniz Ismik, Ayben Kilislioglu. The in-vivo assessment of Turkish propolis and its nano form on testicular damage induced by cisplatin. Journal of Integrative Medicine, 2021, 19(5): 451-459.
[3] Jafar Abolghasemi, Mohammad Ali Farboodniay Jahromi, Mohammad Hossein Sharifi, Zohreh Mazloom, Leila Hosseini, Nasrindokht Zamani, Majid Nimrouzi. Effects of Zataria oxymel on obesity, insulin resistance and lipid profile: A randomized, controlled, triple-blind trial. Journal of Integrative Medicine, 2020, 18(5): 401-408.
[4] Esmaeil Yousefi Rad, Behzad Nazarian, Somayeh Saboori, Ebrahim Falahi, Azita Hekmatdoost. Effects of L-arginine supplementation on glycemic profile: Evidence from a systematic review and meta-analysis of clinical trials. Journal of Integrative Medicine, 2020, 18(4): 284-291.
[5] Sonia Chew Wen Phang, Uma Devi Palanisamy, Khalid Abdul Kadir. Effects of geraniin (rambutan rind extract) on blood pressure and metabolic parameters in rats fed high-fat diet. Journal of Integrative Medicine, 2019, 17(2): 100-106.
[6] Mehranghiz Ebrahimi-Mameghani, Mohammad Asghari-Jafarabadi, Khatereh Rezazadeh. TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: A randomized, double-blind, placebo-controlled trial. Journal of Integrative Medicine, 2018, 16(5): 329-334.
[7] Nanaware Sadhana, Sathiyanarayanan Lohidasan, Kakasaheb Ramoo Mahadik. Marker-based standardization and investigation of nutraceutical potential of Indian propolis. Journal of Integrative Medicine, 2017, 15(6): 483-494.
[8] Tian-zhan Wang, Yu Chen, Yan-ming He, Xiao-dong Fu, Wang Yi, Yan-qiu Xu, Hong-jie Yang, Hong-li Xue, Yi Liu, Xiao-tao Feng, Teng Zhang, Wen-jian Wang. Effects of Chinese herbal medicine Yiqi Huaju Qingli Formula in metabolic syndrome patients with microalbuminuria: a randomized placebo-controlled trial. Journal of Chinese Integrative Medicine, 2013, 11(3): 175-183.
[9] Wen-jian Wang. Enhancing the treatment of metabolic syndrome with integrative medicine. Journal of Chinese Integrative Medicine, 2013, 11(3): 153-156.
[10] Di Li, Guan-liang Wang, Meng-ya Shan, Jia-han Liu, Lin Wang, De-zeng Zhu. Effects of ursolic acid on c-Cbl-associated protein expression in 3T3-L1 adipocytes with insulin resistance. Journal of Chinese Integrative Medicine, 2012, 10(8): 886-893.
[11] Dong-mei Zhang, Li-xia Lou, Ai-ming Wu, Xi-ying Lü, Zhao-juan Hu, Yan-hong Zhang, Hong-fang Liu. Effects of Astragalus membranaceus and Potentilla discolor mixture on insulin resistance and its related mRNA expressions in KKAy mice with type 2 diabetes. Journal of Chinese Integrative Medicine, 2012, 10(7): 821-826.
[12] Lin Wang, Guan-liang Wang, Jia-han Liu, Di Li, De-zeng Zhu, Liang-neng Wu . Effects of ursolic acid in ameliorating insulin resistance in liver of KKAy mice via peroxisome proliferator-activated receptors α and γ. Journal of Chinese Integrative Medicine, 2012, 10(7): 793-799.
[13] Lopes-Rocha Ricardo Barroso Poliana Ribeiro Santos Alexandre Soares Lima Nadia Lages Ferreira Fernanda Oliveiraa Verli Flaviana Dornela . Effects of propolis on lingual mucosa response of hamsters submitted to experimental carcinogenesis. Journal of Chinese Integrative Medicine, 2012, 10(12): 1443-1450.
[14] Susuana Kuek, Wen-jun Wang, Sui-qi Gui. Efficacy of Chinese patent medicine Tian Gui Capsule in patients with polycystic ovary syndrome: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2011, 9(9): 965-972.
[15] Xiang-yu Guo, Ying Duan, Juan-e Li , Li-xia Yang, Lian-sha Huang, Zhi-cheng Wang, He-yao Wang, Tong-hua Liu. Antidiabetic effects of Tangnaikang on obese Zucker rats and the mechanism. Journal of Chinese Integrative Medicine, 2010, 8(6): 535-540.
Full text



[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228