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Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (3): 249-255.doi: 10.3736/jcim20120302

• Review • Previous Articles     Next Articles

An updated review on the parasitic herb of Cuscuta reflexa Roxb

Patel Satish,Sharma Vikas,S. Chauhan Nagendra,K. Dixit Vinod()   

  1. Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar 470003, IndiaDepartment of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar 470003, India
  • Received:2011-11-11 Accepted:2011-12-12 Online:2012-03-20 Published:2018-04-15

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Cuscuta reflexa Roxb. is a golden yellow, leafless, perennial, parasitic herb of the family Convolvulaceae. C. reflexa has been investigated for antispasmodic, hemodynamic, anticonvulsant, antisteroidogenic, antihypertensive, muscle relaxant, cardiotonic, antiviral, antibacterial, antioxidant, cholinergic, diuretic and hair growth activities. Many chemical constituents have been isolated from C. reflexa such as cuscutin, amarbelin, β-sitosterol, stigmasterol, kaempferol, dulcitol, myricetin, quercetin, coumarin and oleanolic acid. This review presents a detailed survey of the literature on pharmacognosy, phytochemistry and traditional and biological medicinal uses of C. reflexa.

Key words: Cuscuta, Convolvulaceae, plants, medicinal, flavonoids, review

"

No. Host plant species Family
1
 Argyreia argentea var. venusta (Choisy) C. B. Clarke. Convolvulaceae
2 Bougainvillea spectabilis Willd. Nyctaginaceae
3 Clerodendrum viscosum Vent. Verbenaceae
4 Jatropha curcas L. Euphorbiaceae
5 Lantana Camera L. Verbenaceae
6 Mikania micrantha (L.) Kunth. Asteraceae
7 Ricinus communis L. Euphorbiaceae
8 Syzygium cumini (L.) Skeels. Myrtaceae
9 Vitex negundo L. Verbenaceae
10 Ziziphus mauritiana Lamk. Rhamnaceae

Figure 1

Structures of some phytoconstituents isolated from Cuscuta reflexa"

[1] Pal D, Panda C, Sinhababu S, Dutta A, Bhattacharya S . Evaluation of psychopharmacological effects of petroleum ether extract of Cuscuta reflexa Roxb. stem in mice. Acta Pol Pharm. 2003; 60(6):481-486.
[2] Govier RN, Nelson MD, Pate JS . Hemiparasitic nutrition in angiosperms. New Phytol. 1967 ; 66(2):285-297.
doi: 10.1111/nph.1967.66.issue-2
[3] Vaughn KC . Dodder hyphae invade the host: a structural and immunocytochemical characterization. Protoplasma. 2003; 220(3-4):189-200.
doi: 10.1007/s00709-002-0038-3
[4] Heide-Jørgensen HS . Notes on structure of the adhesive disk of Cuscuta. In: Ransom JK, Musselman LJ, Worsham AD, Parker C. Proceedings of the 5th International Symposium on Parasitic Weeds. Nairobi: International Maize and Wheat Improvement Center. 1991 : 513.
[5] Vaughn KC . Attachment of the parasitic weed dodder to the host. Protoplasma. 2002; 219(3-4):227-237.
doi: 10.1007/s007090200024
[6] Tenenbaum D, Devitt T . The why files: the science behind the newsj. London: Penguin Books. 2009.
[7] Sarma H, Sarma CM, Bhattacharjya DK . Host specificity of Cuscuta reflexa Roxb. in the manas biosphere reserve, indo-burma hotspot. Int J Plant Prod. 2008; 2(2):175-180.
[8] Subramanian SS, Nair AGR . Chemical components of Cuscuta reflexa(Roxb. ). Indian J Chem. 1963; 1:501.
[9] Dandapani M, Nagarajan S . Isorhamnetin 3-〇-neohes- peridoside from Cuscuta reflexa. Indian J Chem. 1989; 28:606-607.
[10] Ramachandran Nair AG, Thirupurasundari G . Coumarins and flavonoids from Cuscuta reflexa parasitic on Bougainvillea spectabilis. Fitoterapia. 1992; 63:381-382.
[11] Yadav SB, Tripathi V, Singh RK, Pandey HP . Antioxidant activity of Cuscuta reflexa stems. Indian J Pharm Sci. 2000; 62(6):477-478.
[12] Anis E, Anis I, Ahmed S, Mustafa G, Malik A, Afza N, Hai SM , Shahzad-ul-hussan S, Choudhary MI. a-Glucosidase inhibitory constituents from Cuscuta reflexa. Chem Pharm Bull (Tokyo). 2002; 50(1):112-114.
doi: 10.1248/cpb.50.112
[13] Tripathi VJ, Yadav SB, Upadhyay AK . A new flavanone, reflexin, from Cuscuta reflexa and its selective sensing of nitric oxide. Appl Biochem Biotechnol. 2005; 127(1):63-67.
doi: 10.1385/ABAB:127:1
[14] Mukherjee R, Bordoloi J, Goswami A, Goswami BC . Carotenoids of dodder(Cuscuta reflexa ) grown on hedge, Clerodendrum enermy. Adv Nat Appl Sci. 2008; 2(3) : 99-102.
[15] Mythili S, Sathiavelu A, Sridharan TB . Evaluation of antioxidant activity of Cassytha filiformis. Int J Appl Biol Pharm Technol. 2011; 2(2):380-385.
[16] Versiani MA . Studies in the chemical constituents of Bombax ceiba and Cuscuta reflexa. Karachi: University of Karachi/H. E. J Research Institute of Chemistry. 2004.
[17] Loffler C, Sahm A, Wray V, Czygan FC, Proksch P . Soluble phenolic constituents from Cuscuta reflexa and Cuscuta plat yloba. Biochem Syst Ecol. 1995 ; 23(2):121-128.
doi: 10.1016/0305-1978(95)93846-U
[18] Srivastava S, Nighojkar A, Kumar A . Purification and characterization of starch phosphorylase from Cuscuta reflexa filaments. Phytochemistry. 1995; 39(5):1001-1005.
doi: 10.1016/0031-9422(95)00040-E
[19] Choudhury NK, Sahu D . Photosynthesis in Cuscuta reflexa : a total plant parasite. Photosynthetica. 1999 ; 36(1-2):1-9.
doi: 10.1023/A:1007025500452
[20] Masih N, Misra PC . Blue light-sensitive plasma membrane bound exogenous NADH oxidase in Cuscuta reflexa. Indian J Exp Biol. 2000; 38(8):807-813.
[21] Baquar SR, Tasnif M . Medicinal plants of Southern West Pakistan. Karachi: Botany Section, Central Laboratories, Pakistan Council of Scientific and Industrial Research. 1967.
[22] Kirtikar KR, Basum BD . Indian medicinal plants. Vol IE • Delhi: Periodical Experts Book Agency. 1984 : 1740.
[23] Pandit S, Chauhan NS, Dixit VK . Effect of Cuscuta reflexa Roxb on androgen-induced alopecia. J Cosmet Dermatol. 2008; 7(3):199-204.
doi: 10.1111/jcd.2008.7.issue-3
[24] Chopra RN, Nayer SL, Chopra IC . Glossary of Indian medicinal plant. New Delhi: Council of Scientific and Industrial Research. 1956.
[25] Prasad DN . Preliminary pharmacological investigations on Cuscuta reflexa Roxb. Indian J Med Res. 1965 ; 53 : 465-470.
[26] Singh GS, Garg KN . Some pharmacological studies on Cuscuta reflexa plant (Akash Bel). Indian J Pharmacol. 1973; 5(2) : 344-345.
[27] Gilani AUH, Aftab K . Pharmacological actions of Cuscuta re fie xa . Int J Pharmacogn. 1992; 30(4):296-302.
doi: 10.3109/13880209209054017
[28] Kayath HP, Goel NK . Effects of Cuscuta stem extract on various animal tissues. Indian J Pharmacol. 1995; 27(4):227-229.
[29] Mahmood N, Piacente S, Burke A, Khan A, Pizza C . Constituents of Cuscuta reflexa are anti-HIV agents. Antivir Chem Chemother. 1997; 8(1):70-74.
doi: 10.1177/095632029700800108
[30] Srivastava S, Tripathi RD, Dwivedi UN . Synjournal of phytochelatins and modulation of antioxidants in response to cadmium stress in Cuscuta reflexa — an angiospermic parasite. J Plant Physiol. 2004; 161(6):665-674.
doi: 10.1078/0176-1617-01274
[31] Mazumder UK, Gupta M, Pal D, Bhattacharya S . Chemical and toxicological evaluation of methanol extract of Cuscuta reflexa Roxb. stem and Corchorus olitorius Linn, seed on hematological parameters and hepatorenal functions in mice. Acta Pol Pharm. 2003; 60(4) : 317-323.
[32] Gupta M, Mazumder UK, Pal DK, Bhattacharya S . Anti-steroidogenic activity of methanolic extract of Cuscuta reflexa Roxb. stem and Corchorus olitorius Linn, seed in mouse ovary. Indian J Exp Biol. 2003 ; 41(6):641-644.
[33] Pal DK, Mandal M, Senthilkumar GP, Padhiari A . Antibacterial activity of Cuscuta reflexa stem and Corchorus olitorius seed. Fitoterapia. 2006; 77(7-8):589-591.
doi: 10.1016/j.fitote.2006.06.015
[34] UddinSJ, Shilpi JA, Middleton M, Byres M, Shoeb M, Nahar L, Sarker SD . Swarnalin and cis-swarnalin, two new tetrahydrofuran derivatives with free radical scavenging activity, from the aerial parts of Cuscuta reflexa. Nat Prod Res. 2007; 21(7):663-668.
doi: 10.1080/14786410701371405
[35] Balakrishnan BR, Sangameswaran B, Bhaskar VH . Effect of methanol extract of Cuscuta reflexa aerial parts on hepatotoxicity induced by antitubercular drugs in rats. Int J Appl Res Nat Prod. 2010; 3(1) : 18-22.
[36] Rahmatullah M, Sultan S, Toma TT, Lucky SA, Chowdhury MH, Haque WM, Annay EA, Jahan R . Effect of Cuscuta reflexa stem and Calotropis procera leaf extracts on glucose tolerance in glucose-induced hyperglycemic rats and mice. Afr J Tradit Complement Altern Med. 2009; 7(2):109-112.
[37] Sharma S, Hullatti KK, Prasanna SM, Kuppast IJ, Sharma P . Comparative study of Cuscuta reflexa and Cassytha filiformis for diuretic activity. Pharmacognosy Res. 2009; 1(5) : 327-330.
[38] Borole SP, Oswal RJ, Antre RV, Kshirsagar SS, Bagul YR . Evaluation of anti-epileptic activity of Cuscuta reflexa Roxb. Res J Pharm Biol Chem Sci. 2011 ; 2(1):657-663.
[39] Gupta M, Mazumder UK, Pal D, Bhattacharya S, Chakrabarty S . Studies on brain biogenic amines in methanolic extract of Cuscuta reflexa Roxb. and Corchorus olitorius Linn, seed treated mice. Acta Pol Pharm. 2003; 60(3):207-210.
[40] Suresh V, Sruthi V, Padmaja B, Asha VV . In vitro anti-inflammatory and anti-cancer activities of Cuscuta reflexa Roxb. J Ethnopharmacol. 2011; 134(3):872-877.
doi: 10.1016/j.jep.2011.01.043
[41] Chatterjee D, Sahu RK, Jha AK, Dwivedi J . Evaluation of antitumor activity of Cuscuta reflexa Roxb (Cuscutaceae) against Ehrlich ascites carcinoma in Swiss albina mice. Trop J Pharm Res. 2011; 10(4):447-454.
[42] Khan S, Mirza KJ, Abdin MZ . Development of RAPD markers for authentication of medicinal plant Cuscuta reflexa. EurAsian J BioSci. 2010 ; 4(1) : 1-7.
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