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Journal of Integrative Medicine ›› 2020, Vol. 18 ›› Issue (3): 189-195.doi: 10.1016/j.joim.2020.02.006

• Review •     Next Articles

Phenolic constituents and anticancer properties of Morus alba (white mulberry) leaves

Eric Wei Chiang Chana, Siu Kuin Wongb, Joseph Tangahc, Tomomi Inoued, Hung Tuck Chane   

  1. a. Faculty of Applied Sciences, UCSI University, 56000 Cheras, Kuala Lumpur, Malaysia
    b. School of Foundation Studies, Xiamen University Malaysia, 43900 Sepang, Selangor, Malaysia
    c. Forest Research Centre, Sabah Forestry Department, 90009 Sandakan, Sabah, Malaysia
    d. Centre for Environmental Biology and Ecosystem Studies, National Institute for Environmental Studies (NIES), Onogawa, Tsukuba 305-0053, Japan
    e. Secretariat of International Society for Mangrove Ecosystems (ISME), Faculty of Agriculture, University of the Ryukyus, Okinawa 903-0129, Japan
  • Received:2019-10-10 Accepted:2020-01-14 Online:2020-05-08 Published:2020-02-20
  • Supported by:

    The review article was prepared by the authors without any external funding.

Flavonoids are by far the most dominant class of phenolic compounds isolated from Morus alba leaves (MAL). Other classes of compounds are benzofurans, phenolic acids, alkaloids, coumarins, chalcones and stilbenes. Major flavonoids are kuwanons, moracinflavans, moragrols and morkotins. Other major compounds include moracins (benzofurans), caffeoylquinic acids (phenolic acids) and morachalcones (chalcones). Research on the anticancer properties of MAL entailed in vitro and in vivo cytotoxicity of extracts or isolated compounds. Flavonoids, benzofurans, chalcones and alkaloids are classes of compounds from MAL that have been found to be cytotoxic towards human cancer cell lines. Further studies on the phytochemistry and anticancer of MAL are suggested. Sources of information were PubMed, PubMed Central, ScienceDirect, Google, Google Scholar, J-Stage, PubChem and China National Knowledge Infrastructure.

Key words: Flavonoids, Benzofurans, Cytotoxic, Moracins, Morachalcones, Chalcomoracin

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