人参果总皂苷对高脂饲养大鼠胰岛素敏感指数的影响

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Effect of ginseng fruit saponins on insulin sensitivity index in high fat-fed rats

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doi:10.3736/jcim20050611

Objective

To observe the effect of ginseng fruit saponins (GFS) on insulin sensitivity index in high fat-fed rats.

Methods

An animal model of insulin resistance was established by injecting low dose of streptozotocin (STZ) in high fat-fed rats. Effect of GFS on insulin sensitivity was detected with glucose infusion rate (GIR) by euglycemic hyperinsulinemic clamp technique.

Results

The level of fasting blood glucose and insulin in untreated group increased more significantly than that in normal control group (P<0.05, P<0.01), while the index of GIR decreased significantly (P<0.01). As compared with the untreated group, the parameters of GFS-treated groups were improved significantly in a dosage-dependent manner (P<0.05, P<0.01).

Conclusion

GFS can improve experimental insulin resistance in rats.

Key words: Ginseng fruit saponins, Insulin resistance, Insulin sensitivity index

CLC Number:

R733.72

Lan Luo, Hui-jun Yin, Ying Zhang, Yue-rong Jiang, Ying Liu, Da-zhuo Shi. Effect of ginseng fruit saponins on insulin sensitivity index in high fat-fed rats. Journal of Chinese Integrative Medicine, 2005, 3(6): 463-465.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20050611

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Group	n	Blood glucose (mmol/L)	Serum insulin (mU/L)	Insulin sensitivity index
Normal control	10	4.24±0.88	35.56±4.27	–2.55±0.42
High fat-fed	10	5.34±1.27*	55.21±16.32**	–3.59±0.38*

Group	n	Fasting blood-glucose (mmol/L)	Serum insulin (mU/L)	GIR (mg·kg^–1·min^–1)
Normal control	10	4.56±0.32	42.01±0.47	12.41±1.86
Untreated	10	5.53±0.85**	136.20±0.48**	5.78±1.96**
High-dose GFS-treated	10	4.95±0.68^△△	73.50±0.75^△△	9.13±2.58^△△
Low-dose GFS-treated	10	5.29±0.38^△△	93.80±0.57^△△	7.53±1.79^△
Rosiglitazone-treated	10	4.48±0.74^△△	48.90±0.60^△△	12.56±3.18^△△

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