Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (12): 1114-1118.doi: 10.3736/jcim20101202

Special Issue: Traditional Chinese Medicine

• Review • Previous Articles     Next Articles

Relationships between insulin resistant and hypertension and traditional Chinese medicine intervention

 YiChen,Wen-jianWang   

  1. Institute of Integrated Traditional Chinese and Western Medicine, Fudan University, Shanghai 200040, China
  • Received:2010-07-15 Accepted:2010-09-02 Online:2010-12-20 Published:2010-08-15
  • Contact: Wen-jian Wang E-mail:wj6518@163.com

Recently many researches have demonstrated that insulin resistant (IR), as an important pathologic process, is increasingly involved with a series of diseases such as central obesity and diabetes. Hypertension is highly associated with IR. The relationships between IR and glucose or lipid metabolism disorders are well established. However, association of IR with hypertension is less covered. Current researches on insulin resistance and pathogenesis of hypertension are reviewed in this paper, which holds that traditional Chinese medicine treatment on IR in patients with hypertension has a good prospect.

Key words: Insulin resistance, Hypertension, Metabolic syndrome X, Drugs,Chinese herbal

[1] Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, Hailpern SM, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O’ Donnell C, Roger V, Sorlie P, Steinberger J, Thom T, Wilson M, Hong Y. Heart disease and stroke statistics — 2008 update : a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008; 117(4) e25-el46.
doi: 10.1161/CIRCULATIONAHA.107.187998
[2] Morisco C, Lembo G, Trimarco B . Insulin resistance and cardiovascular risk: New insights from molecular and cellular biology. Trends Cardiovasc Med. 2006; 16(6) 183-188.
doi: 10.1016/j.tcm.2006.03.008
[3] Cordero A, Laclaustra M, León M, Grima A, Casasnovas JA, Luengo E, del Rio A , Ferreira I, Alegria E . Prehypertension is associated with insulin resistance state and not with an initial renal function impairment. A metabolic syndrome in active subjects in spain (MESYAS) registry substudy. Am J Hypertens . 2006; 19(2):189-196.
doi: 10.1016/j.amjhyper.2005.08.018
[4] Guo X, Cheng S, Taylor KD, Cui J, Hughes R, Quinones MJ, Bulnes-Enriquez I, De la Rosa R, Aurea G, Yang H, Hsueh W, Rotter JI. Hypertension genes are genetic markers for insulin sensitivity and resistance. Hypertension. 2005; 45(4):799-803.
doi: 10.1161/01.HYP.0000154786.17416.ea
[5] Liu Y, Wang WJ . Professor Wang Wen-jian’s clinical experience in treating metabolic syndrome. Shanghai Zhong Yi Yao Za Zhi. 2008; 42(8):7-9. Chinese with abstract in English.
刘毅, 王文健 . 王文健中西医结合防治代谢综合征的经验.上海中医药杂志. 2008; 42(8):7-9.
[6] Fukushima T, Nedachi T, Akizawa H, Akahori M, Hakuno F, Takahashi S . Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3’, 5’-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kipl in FRTL-5 cells. Endocrinology. 2008; 149(7):3729-3742.
doi: 10.1210/en.2007-1443
[7] Kasuga K, Kaneko H, Nishizawa M, Onodera O, Ikeuchi T . Generation of intracellular domain of insulin receptor tyrosine kinase by gamma-secretase. Biochem Biophys Res Commun. 2007; 360(1):90-96.
doi: 10.1016/j.bbrc.2007.06.022
[8] Hernández-Sánchez C, Bartulos O, Valenciano AI, Mansilla A, de Pablo F . The regulated expression of chimeric tyrosine hydroxylase-insulin transcripts during early development. Nucleic Acids Res. 2006; 34(12):3455-3464.
doi: 10.1093/nar/gkl436
[9] Shen XC, Qian ZY . Effects of crocetin on antioxidant enzymatic activities in cardiac hypertrophy induced by norepinephrine in rats. Pharmazie. 2006; 61(4) : 348-352.
[10] Hamburg NM, Larson MG, Vita JA, Vasan RS, Keyes MJ, Widlansky ME, Fox CS, Mitchell GF, Levy D, Meigs JB, Benjamin EJ . Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease. Am[J] Cardiol. 2008; 101(1):82-88.
doi: 10.1016/j.amjcard.2007.07.053
[11] Sarafidis PA, Bakris GL . Insulin and endothelin: an interplay contributing to hypertension development?[J] Clin Endocrinol Metab. 2007; 92(2):379-385.
doi: 10.1210/jc.2006-1819
[12] Umar A, Imam G, Yimin W, Kerim P, Tohti I, Berke B, Moore N . Antihypertensive effects of Ocimum basi- licum L.(OBL) on blood pressure in renovascular hypertensive rats. Hypertens Res. 2010; 33(7) : 727-730.
doi: 10.1038/hr.2010.64
[13] De Ciuceis C, Rizzoni D, Porteri E, Boari GE, Zani F, Miclini M, Tiberio GA, Giulini SM, Paiardi S, Rizzardi N, Platto C, Agabiti-Rosei E . Effects of insulin on endothelial and contractile function of subcutaneous small resistance arteries of hypertensive and diabetic patients.[J] Vase Res. 2008; 45(6):512-520.
doi: 10.1159/000128604
[14] Hartell NA, Archer HE, Bailey CJ . Insulin-stimulated endothelial nitric oxide release is calcium independent and mediated via protein kinase B. Biochem Pharmacol. 2005; 69(5) : 781-790.
doi: 10.1016/j.bcp.2004.11.022
[15] Toutouzas K, Riga M, Stefanadi E, Stefanadis C . Asymmetric dimethylarginine( ADMA) and other endogenous nitric oxide synthase (NOS) inhibitors as an important cause of vascular insulin resistance. Horm Metab Res. 2008; 40(9):655-659.
doi: 10.1055/s-0028-1083814
[16] Deng G, Yu YR. Radix Astragali improves impaired endothelial dependent vasodilation in obese rat. Sichuan Da Xue Xue Bao Yi Xue Ban. 2009; 40(4):608-611. Chinese with abstract in English.
邓刚, 余叶蓉 . 中药黄芪对肥胖大鼠内皮血管舒张功能的影响. 四川大学学报(医学版). 2009; 40(4):608-611.
[17] Wang XL, Zhang L, Youker K, Zhang MX, Wang J , LeMaire SA,Coselli JS,Shen YH. Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase. Diabetes. 2006; 55(8):2301-2310.
doi: 10.2337/db05-1574
[18] Gu Y, Zhang Y, Shi X, Li X, Hong J, Chen J, Gu W, Lu X, Xu G, Ning G . Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics. Talanta. 2010; 81(3):766-772.
doi: 10.1016/j.talanta.2010.01.015
[19] Tesauro M, Rizza S, Iantorno M, Campia U, Cardillo C, Lauro D, Leo R, Turriziani M, Cocciolillo GC, Fusco A, Panza JA, Scuteri A, Federici M, Lauro R, Quon MJ . Vascular, metabolic, and inflammatory abnormalities in normoglycemic offspring of patients with type 2 diabetes mellitus. Metabolism. 2007 ; 56(3):413-419.
doi: 10.1016/j.metabol.2006.10.026
[20] Hodgkin MN, Hills CE, Squires PE . The calciumsensing receptor and insulin secretion: a role outside systemic control 15 years on.[J] Endocrinol. 2008; 199(1):1-4.
doi: 10.1677/JOE-08-0261
[21] Miura Y, Matsui H . Triphenyltin impairs a protein kinase A (PKA)-dependent increase of cytosolic Na + and Ca 2+ and PKA-independent increase of cytosolic Ca 2+ associated with insulin secretion in hamster pancreatic beta-cells. Toxicol Appl Pharmacol. 2006; 216(3):363-372.
[22] Park JW, Lee SH, Yang MK, Lee JJ, Song MJ, Ryu SY, Chung HJ, Won HS, Lee CS, Kwon SH, Yun YP, Choi WS, Shin HS . 15,16-dihydrotanshinone I , a major component from Salvia miltiorrhiza Bunge (Dansham), inhibits rabbit platelet aggregation by suppressing intracellular calcium mobilization. Arch Pharm Res. 2008; 31(1):47-53.
doi: 10.1007/s12272-008-1119-4
[23] Fidan Yaylali G, Akin F, Turgut S, Kursunluoglu R . IGF-1 gene polymorphism in obese patients with insulin resistance. Mol Biol Rep. 2010; 37(1):529-533.
doi: 10.1007/s11033-009-9729-6
[24] Suzuki A, Ogura T, Esumi H . NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling.[J] Biol Chem. 2006; 281(20):13915-13921.
doi: 10.1074/jbc.M511354200
[25] Perrotti N, He RA, Phillips SA, Haft CR, Taylor SI . Activation of serum- and glucocorticoid-induced protein kinase (Sgk) by cyclic AMP and insulin. J Biol Chem. 2001; 276(12) : 9406-9412.
doi: 10.1074/jbc.M007052200
[26] Sievers C, Schneider HJ, Stalla GK . Insulin-like growth factor-1 in plasma and brain : regulation in health and disease. Front Biosci. 2008; 13:85-99.
doi: 10.2741/2662
[27] Duan XZ, Sun XQ, Wang Y , Cai XJ. Effect of Yixin Jiangya Capsule on serum insulin-like growth factor-1 level in patients of left ventrecular hypertrophy of primary hypertension. Zhongguo Zhong Yi Yao Xin Xi Za Zhi. 2006; 13(9):20-21. Chinese with abstract in English.
段学忠, 孙西庆, 王勇, 蔡新吉 . 益心降压胶囊对原发性髙血压左室肥厚患者血清胰岛素样生长因子-1水平的影响.中国中医药信息杂志. 2006; 13(9):20-21.
[28] Usukura M, Zhu A, Yoneda T, Karashima S, Yagi K, Yamagishi M, Takeda Y . Effects of a high-salt diet on adipocyte glucocorticoid receptor and 11-beta hydroxys- teroid dehydrogenase 1 in salt-sensitive hypertensive rats. Steroids. 2009; 74(12):978-982.
doi: 10.1016/j.steroids.2009.07.006
[29] Zheng Y, Yamada H, Sakamoto K, Horita S, Kunimi M, Endo Y, Li Y, Tobe K, Terauchi Y, Kadowaki T, Seki G, Fujita T . Roles of insulin receptor substrates in absorption.[J] Am Soc Nephrol. 2005; 16(8):2288-2295.
doi: 10.1681/ASN.2005020193
[30] Zhang SL, Chen X, Hsieh TJ, Leclerc M, Henley N, Allidina A, Halle JP, Brunette MG, Filep JG, Tang SS, Ingelfinger JR, Chan JSD . Hyperglycemia induces insulin resistance on angiotensinogen gene expression in diabetic rat kidney proximal tubular cells.[J] Endocrinol. 2002; 172(2) : 333-344.
doi: 10.1677/joe.0.1720333
[31] Vedovato M, Lepore G, Coracina A, Dodesini AR, Jori E, Tiengo A, Del Prato S, Trevisan R . Effect of sodium intake on blood pressure and albuminuria in Type 2 diabetic patients: the role of insulin resistance. Diabeto- logia. 2004; 47(2):300-303.
doi: 10.1007/s00125-003-1303-5
[32] Kuang AK, Gu DG, Gu TH, Mao SY, Wang H. Experimental research of yin-yang theory of traditional Chinese medicine ( I )— Effect of mankshood, bark of Chinese cassia tree and “Liuwei Dihuang Fang” on arterial pressure in experimental hypertensive rats. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1984; 4(12) : 742-744, 709. Chinese with abstract in English.
邝安堃, 顾德官, 顾天华, 茅守玉, 王洪 . 中医阴阳的实验研究(I)——附子、肉桂和六味地黄方对实验性髙血压大鼠血压的影响. 中国中西医结合杂志. 1984; 4(12) : 742-744, 709.
[33] Lamounier-Zepter V, Ehrhart-Bornstein M, Bornstein SR . Insulin resistance in hypertension and cardiovascular disease. Best Pract Res Clin Endocrinol Metab. 2006; 20(3) : 355-367.
doi: 10.1016/j.beem.2006.07.002
[34] Furuhashi M, Ura N, Takizawa H, Yoshida D, Moniwa N, Murakami H, Higashiura K, Shimamoto K . Blockade of the renin-angiotensin system decreases adipocyte size with improvement in insulin sensitivity. J Hypertens. insulin-induced stimulation of renal proximal bicarbonate 2004 ; 22(10) : 1977-1982.
[1] Shuai Chen, Jin Hu, Deng-cheng Lu, Hong-yi Liu, Shan-shan Wei. Metabolomic characteristics of spontaneously hypertensive rats under chronic stress and the treatment effect of Danzhi Xiaoyao Powder, a traditional Chinese medicine formula. Journal of Integrative Medicine, 2022, 20(1): 73-82.
[2] Rakhi Chakraborty, Swarnendu Roy. Angiotensin-converting enzyme inhibitors from plants: A review of their diversity, modes of action, prospects, and concerns in the management of diabetes-centric complications. Journal of Integrative Medicine, 2021, 19(6): 478-492.
[3] Jafar Abolghasemi, Mohammad Ali Farboodniay Jahromi, Mohammad Hossein Sharifi, Zohreh Mazloom, Leila Hosseini, Nasrindokht Zamani, Majid Nimrouzi. Effects of Zataria oxymel on obesity, insulin resistance and lipid profile: A randomized, controlled, triple-blind trial. Journal of Integrative Medicine, 2020, 18(5): 401-408.
[4] Esmaeil Yousefi Rad, Behzad Nazarian, Somayeh Saboori, Ebrahim Falahi, Azita Hekmatdoost. Effects of L-arginine supplementation on glycemic profile: Evidence from a systematic review and meta-analysis of clinical trials. Journal of Integrative Medicine, 2020, 18(4): 284-291.
[5] Pranay Soni, Rajesh Choudhary, Surendra H. Bodakhe. Effects of a novel isoflavonoid from the stem bark of Alstonia scholaris against fructose-induced experimental cataract. Journal of Integrative Medicine, 2019, 17(5): 374-382.
[6] Sonia Chew Wen Phang, Uma Devi Palanisamy, Khalid Abdul Kadir. Effects of geraniin (rambutan rind extract) on blood pressure and metabolic parameters in rats fed high-fat diet. Journal of Integrative Medicine, 2019, 17(2): 100-106.
[7] Mehranghiz Ebrahimi-Mameghani, Mohammad Asghari-Jafarabadi, Khatereh Rezazadeh. TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: A randomized, double-blind, placebo-controlled trial. Journal of Integrative Medicine, 2018, 16(5): 329-334.
[8] Nazli Samadi, Hassan Mozaffari-Khosravi, Masoud Rahmanian, Mohsen Askarishahi. Effects of bee propolis supplementation on glycemic control, lipid profile and insulin resistance indices in patients with type 2 diabetes: A randomized, double-blind clinical trial. Journal of Integrative Medicine, 2017, 15(2): 124-134.
[9] Nathalia Gomes Ribeiro de Moura, Ivan Cordovil, Arthurde Sá Ferreira. Traditional Chinese medicine wrist pulse-taking is associated with pulse waveform analysis and hemodynamics in hypertension. Journal of Integrative Medicine, 2016, 14(2): 100-113.
[10] Nouran A. Aleyeidi, Khaled S. Aseri, Shadia M. Matbouli, Albaraa A. Sulaiamani, Sumayyah A. Kobeisy. Effects of wet-cupping on blood pressure in hypertensive patients: A randomized controlled trial. Journal of Integrative Medicine, 2015, 13(6): 391-399.
[11] Kylie Connolly, Douglas Jackson, Candice Pullen, Andrew Fenning. Alpha-adrenoceptor antagonism by Crassostrea gigas oyster extract inhibits noradrenaline-induced vascular contraction in Wistar rats. Journal of Integrative Medicine, 2015, 13(3): 194-200.
[12] Ya Yuwen, Yu-qi Liu, Yan-ping Wang, Jin-gang Dai, Da-sheng Liu, Yue-xi Wang, Xue-jie Han. The add-on effect of a Chinese herbal formula for patients with resistant hypertension: Study protocol for a pilot cohort study. Journal of Integrative Medicine, 2015, 13(2): 122-128.
[13] Vamsi Reddy, Arvind Sridhar, Roberto F. Machado, Jiwang Chen. High sodium causes hypertension: Evidence from clinical trials and animal experiments. Journal of Integrative Medicine, 2015, 13(1): 1-8.
[14] Yong-hong Lian, Mei-xia Fang, Li-guo Chen. Constructing protein-protein interaction network of hypertension with blood stasis syndrome via digital gene expression sequencing and database mining. Journal of Integrative Medicine, 2014, 12(6): 476-482.
[15] Rajadurai Akilen​, Zeller Pimlott​, Amalia Tsiami​, Nicola Robinson​. The use of complementary and alternative medicine by individuals with features of metabolic syndrome. Journal of Integrative Medicine, 2014, 12(3): 171-174.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228