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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (3): 180-183.doi: 10.3736/jcim20030310

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Quantitative study on tongue color in primary liver cancer patients by analysis system for comprehensive information of tongue diagnosis

Qing Liu(), Xiao-qiang Yue, Wei-zhe Deng, Rong-zheng Ren, Chang-quan Ling   

  1. Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Received:2003-09-01 Online:2003-09-20 Published:2003-09-20


To explore the characteristics of tongue color in patients with primary liver cancer (PLC).


Tongue color and its RGB value were analyzed quantitatively for PLC patients in different clinical periods and other cancer patients by analysis system for comprehensive information of tongue diagnosis.


The rate of blue and purple tongue was higher (P <0.05) and all the values of RGB were lower (P <0.01) in PLC patients compared with other cancer patients. In different clinical periods, the rate of blue and purple tongue in stage Ⅲ was the highest (P <0.05).


The blue and purple tongue is one of the most important tongue characteristics of PLC patients.

Key words: tongue, color, liver neoplasms, clinical research, image processing, computer-assisted

CLC Number: 

  • R735.7


组别 n 舌 质 颜 色[n(%)]
淡白 淡红 青紫
肝癌组 332 28(8.43)△△ 95(28.61)△△ 34(10.24)△△ 6(1.81) 90(27.11)*△△ 79(23.80)*△△
其他肿瘤组 196 18(9.18)△△ 65(33.16)△△ 12(6.12)△△ 3(1.53) 35(17.86)△△ 63(32.14)△△
正常组 108 5(2.55) 86(43.88) 1(0.51) 0(0.00) 3(1.53) 13(6.63)


组别 n R值 G值 B值 H值
肝癌组 332 169.9±15.92*△△ 119.41±21.56** 131.95±19.67** 14.42±6.19△△
其他肿瘤组 196 173.18±14.50△△ 125.52±20.36 137.86±19.44 15.27±6.90△△
正常组 108 178.37±13.07 121.91±16.60 132.41±15.48 10.22±3.75


组别 n 舌 质 颜 色[n(%)]
淡白 淡红 青紫
Ⅰ期 35 4(11.43) 12(34.29) 6(17.14) 1(2.86) 6(17.14) 6(17.14)
Ⅱ期 223 18(8.07) 59(26.46) 18(8.07) 2(0.90) 62(27.80) 64(28.70)
Ⅲ期 74 6(8.11) 14(18.92) 10(13.51) 3(4.05) 32(43.24) 9(12.16)


临床分期 n R值 G值 B值 H值
Ⅰ期 35 167.83±16.16 121.31±19.73 132.00±17.95 13.18±6.50
Ⅱ期 223 170.39±15.54 119.51±21.28 132.21±19.60 14.53±6.30
Ⅲ期 74 169.42±17.02 118.20±23.36 131.12±20.90 14.69±5.72
[1] 刘庆, 岳小强, 凌昌全 . 舌诊客观化研究的现状与展望[J]. 中西医结合学报, 2003,1(1):66-70
doi: 10.3321/j.issn:1001-1668.2004.02.044
Liu Q, Yue XQ, Ling CQ . Researches into the modernization of tongue diagnosis: in retrospect and prospect[J]. Zhong Xi Yi Jie He Xue Bao, 2003,1(1):66-70
[2] 中国抗癌协会肝癌专业委员会. 原发性肝癌的临床诊断与分期标准[J]. 中华肝脏病杂志, 2001,9(6):324
[3] 赵忠旭, 王爱民, 沈兰荪 . 基于数学形态学和HSI模型的彩色舌图像分割[J]. 北京工业大学学报, 1999,25(2):67-71
[4] 刘庆, 凌昌全 . 原发性肝癌的舌象研究[J]. 肿瘤防治研究, 2003,30(4):337-339
doi: 10.3971/j.issn.1000-8578.1418
[5] 翁维良, 黄世敬, 洪尚杓 . 运用“中医舌诊专家系统”对血瘀证舌质的研究[J]. 中国中医基础医学杂志, 2000,6(10):58-61
doi: 10.3969/j.issn.1006-3250.2000.10.023
[6] 王榕平 . 原发性肝癌的肝瘿线与血液流变学关系初探[J]. 中西医结合杂志, 1987,7(12):734-735
[7] 刘庆, 岳小强, 侯凤刚 , 等. 血瘀证与肝癌关系浅析——附1 010篇(本)相关文献分析[J]. 山东中医药大学学报, 2003,27(2):92-94
doi: 10.3969/j.issn.1007-659X.2003.02.003
[8] 汤顺青 . 色度学(第1版)[M]. 北京: 北京理工大学出版社, 1990,( 第1版):33
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