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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (3): 202-204.doi: 10.3736/jcim20030317

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Pingfei Mixture's two-way adjustment to cell proliferation in mice with tumor

Shi-jie Zhu(), Pei-wen Li, Li-qun Jia   

  1. Tumor Department of Traditional Chinese Medicine, China-Japan Friendship Hospital, Beijing 100029, China
  • Received:2003-06-25 Online:2003-09-20 Published:2003-09-20


To study the antineoplastic mechanism of Pingfei Mixture.


Thirty C57BL mice bearing Lewis pulmonary carcinoma were randomly divided into 3 groups: saline control group, Pingfei Mixture group and cisplatin group. Fifteen days later, tumor tissues and spleens were taken out and made into unicellular suspension. Argyrophil staining was taken to carcinoma cells and cultured T cells. KL-2 style cell image analysis system was used to analyze the rate between AgNORs and nuclear region (I.S).


There were dense brownish-black granules in tumor cell nuclear of saline control group. The brownish-black granules of Pingfei Mixture group and cisplatin group were less than those of saline control group. The differences of T cell I.S in these three groups were significant. The I.S of Pingfei Mixture was higher than that of the other groups, and the I.S of the cisplatin group was the lowest.


Pingfei Mixture can inhibit tumor cell proliferation, although the effect is inferior to cisplatin. Pingfei Mixture can also promote T cell proliferation and its effect was superior to cisplatin.

Key words: cell proliferation, drugs, Chinese herbal, neoplasms

CLC Number: 

  • R730.52


组别 n 平均瘤重(g) 抑瘤率(%)
空白对照组 10 1.13±0.3
平肺口服液组 10 0.71±0.5△△ 37.2
化疗组 10 0.45±0.3*△△ 60.2


组别 n 肿瘤细胞I.S T淋巴细胞I.S
空白对照组 10 25.7±3.1 3.1±0.8
平肺口服液组 10 12.5±2.3** 13.1±0.5**
化疗组 10 10.8±1.5** 1±0.3*△△
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