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Journal of Chinese Integrative Medicine ›› 2011, Vol. 9 ›› Issue (5): 525-530.doi: 10.3736/jcim20110509

• Original Clinical Research • Previous Articles     Next Articles

Effects of chemotherapy combined with Chinese herbal medicine Kangliu Zengxiao Decoction on tumor markers of patients with advanced non-small-cell lung cancer: A randomized, controlled trial

Gui-ying Yan1, Zhen-ye Xu2(),Hai-bin Deng2, Zhi-yong Wan1, Lei Zhang1, Jiao-yu Zhu3   

  1. 1. Department of Oncology, Punan Hospital of Pudong New District, Shanghai 200125, China
    2. Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
    3. Department of Emergency, Shanghai TCM-integrated Hospital, Shanghai 200082, China
  • Received:2010-12-14 Accepted:2011-02-15 Online:2011-05-20 Published:2011-05-15
  • Contact: Xu Zhen-ye E-mail:xuzhenye1947@126.com

Background: Tumor markers are widely used in clinical practice and have become important indicators in assessing cancer progress. There is increasing concern that chemotherapy combined with traditional Chinese medicine has effects in decreasing the level of tumor markers.
Objective: To investigate the effects of chemotherapy combined with Kangliu Zengxiao Decoction (KLZX), a compound Chinese herbal drug, on tumor markers carbohydrate antigen 50 (CA 50), cytokeratin 19 fragment (CYFRA21-1) and carcinoembryonic antigen (CEA) in patients with advanced non-small-cell lung cancer (NSCLC) and to explore the relationships between clinical efficacy and tumor markers.
Design, setting, participants and interventions: Patients were included from Punan Hospital of Shanghai Pudong New District and Longhua Hospital between October 2008 and December 2009. Seventy-four subjects with advanced NSCLC were randomly assigned into treatment group (n=37) and control group (n=37). Patients in the control group were treated with chemotherapy alone while patients in the treatment group were treated with chemotherapy combined with KLZX. Chemotherapy of NP (vinorelbine + cisplatin) was given for two cycles and patients in the treatment group were administered with KLZX during chemotherapy.
Main outcome measures: Levels of CA50, CYFRA21-1 and CEA before and after treatment were evaluated and the relationship between changes in levels of tumor makers and tumor size, clinical symptoms and living condition score (Karnofsky score) was analyzed.
Results: No patients achieved a complete remission. The disease control rates (complete remission (CR)+partial remission (PR)+no change (NC)) were 89.20% (33/37) and 70.30% (26/37) in the treatment and control group respectively (P<0.05). The levels of CA50, CYFRA21-1 and CEA were clearly decreased in the treatment group after treatment (P<0.05) while also decreased in the patients without progression of disease. There were no obvious changes of CA50, CYFRA21-1 and CEA in the control group, and there was even a trend of increase. Furthermore, the improvement rates of clinical syndrome were 51% (19/37) vs 11% (4/37) (P<0.05) in the treatment group and control group respectively. The total response rates of quality of life were 91.89% (34/37) vs 56.76% (21/37) (P<0.01) in the treatment and control group respectively.
Conclusion: Combined chemotherapy with KLZX in treating advanced NSCLC can acquire better stabilizing tumor foci, decrease levels of tumor markers and improve the clinical symptoms and Karnofsky score.

Key words: carcinoma,non-small cell lung, antineoplastic combined chemotherapy protocols, drugs,Chinese herbal, tumor markers,biological, antigen,tumor-related,carbohydrate, randomized controlled trial, prospective study

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Figure 1

Flow diagram of this randomized trial"

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[1] Li CH . Strengthen the establishment and evaluation of tumor makers[J]. Zhonghua Jian Yan Yi Xue Za Zhi, 2000,23(1):6-8
doi: 10.3760/j:issn:1009-9158.2000.01.002
李春海 . 加强肿瘤生物学标志的研究和评价[J]. 中华检验医学杂志, 2000,23(1):6-8
doi: 10.3760/j:issn:1009-9158.2000.01.002
[2] Chen W, Sun YL, Xi Y . Correlation between serum tumor marker level and stage, therapeutic response and survival in patients with lung cancer[J]. Biao Ji Mian Yi Fen Xi Yu Lin Chuang, 2008,15(4):209-211, 221
doi: 10.3969/j.issn.1006-1703.2008.04.006
陈武, 孙艳丽, 席妍 . 肿瘤标志物水平与肺癌分期、近期疗效及生存时间的相关性的临床观察[J]. 标记免疫分析与临床, 2008,15(4):209-211, 221
doi: 10.3969/j.issn.1006-1703.2008.04.006
[3] Le Cesne A, Arriagada R, Grunenwald D, Baldeyrou P, Girard P, Bretel JJ, Le Chevalier T . New therapeutic strategies and current research in inoperable locally advanced non-small-cell lung cancers(stage ⅢB)[J]. Bull Cancer, 1997,84(4):413-419
[4] Xu ZY, Yang YF. Integrated traditional Chinese and Western medicine in lung cancer[M]. Beijing: People's Medical Publishing House,2002:451- 456, 815-816
徐振晔, 杨宇飞 . 肺癌中西医综合治疗[M]. 北京: 人民卫生出版社,2002:451- 456, 815-816
[5] Zheng XY. Guidelines for clinical research on Chinese herbal medicines(trail implementation)[M]. Beijing: China Medical Science Press, 2002: 216-221
郑筱萸 . 中药新药临床研究指导原则(试行)[M]. 北京: 中国医药科技出版社, 2002: 216-221
[6] Zha RJ, He CQ, Zeng DW, Huang XM. Diagnosis and treatment of lung cancer in modern times [M]. Beijing: People's Military Medical Press, 1999,( 2nd ed):414-417
查人俊, 何长清, 曾逖闻, 黄孝迈 . 现代肺癌诊断与治疗 [M]. 北京: 人民军医出版社, 1999,( 第2版):414-417
[7] Shi YH, Lu XL . Application of serum CA-50 in diagnosis and treatment of tumor[J]. Jiangsu Yi Yao, 1998,24(2):139
石寅皓, 陆雪龙 . 肿瘤标志物在CA-50在肿瘤诊治中的应用[J]. 江苏医药, 1998,24(2):139
[8] Xue QP, Qiu XH, Yang MN . Application of serum tumor specific growth factor, CA-50 and CA19-9 in diagnosis[J]. Nanjing Yi Ke Da Xue Xue Bao Zi Ran Ke Xue Ban, 2001,21(3):270-271
doi: 10.3969/j.issn.1007-4368.2001.03.037
薛绮萍, 仇晓华, 杨美南 . 肿瘤特异性生长因子及肿瘤标志物CA-50、CA19-9在诊断中的应用[J]. 南京医科大学学报: 自然科学版, 2001,21(3):270-271
doi: 10.3969/j.issn.1007-4368.2001.03.037
[9] Hatzakis KD, Froudarakis ME, Bouros D, Tzanakis N, Karkavitsas N, Siafakas NM . Prognostic value of serum tumor markers in patients with lung cancer[J]. Respiration, 2002,69(1):25-29
doi: 10.1159/000049366
[10] Li H, Wan ZF . Clinical value of combined determination of serum CEA and CYFRA21-1 levels for diagnosis of NSCLC[J]. Fang She Mian Yi Xue Za Zhi, 2006,19(5):432-433
doi: 10.3969/j.issn.1008-9810.2006.05.052
李红, 万自芬 . 肿瘤标志物CEA、CYFRA21-1联检在非小细胞肺癌中的诊断价值[J]. 放射免疫学杂志, 2006,19(5):432-433
doi: 10.3969/j.issn.1008-9810.2006.05.052
[11] Carpelan-Holmstrom M, Louhimo J, Stenman UH, Alfthan H, Jarvinen H, Haglund C . CEA, CA 242, CA 19-9, CA 72-4 and hCGbeta in the diagnosis of recurrent colorectal cancer[J]. Tumour Biol, 2004,25(5-6):228-234
doi: 10.1159/000081385
[12] Foa P, Fornier M, Miceli R, Seregni E, Santambrogio L, Nosotti M, Cataldo I, Sala M, Caldiera S, Bombardieri E . Tumour markers CEA, NSE, SCC, TPA and CYFRA 21.1 in resectable non-small cell lung cancer[J]. Anticancer Res, 1999,19(4C):3613-3618
pmid: 10629660
[13] Du TX, Wang ZZ, Tian R . Changes of NSE, CYFRA21-1 and CEA observed by RIA in patients with lung tumor[J]. Zhong Liu Fang Zhi Yan Jiu, 2000,27(3):172-174
doi: 10.3971/j.issn.1000-8578.1682
杜同信, 王自正, 田韧 . 肺癌患者NSE、CYFRA21-1、CEA RIA水平变化的分析研究[J]. 肿瘤防治研究, 2000,27(3):172-174
doi: 10.3971/j.issn.1000-8578.1682
[14] Gao WH, Zhao XD, Zhou CC . Application value of serum tumour markers in chemotherapy for non-small-cell lung cancer[J]. Lin Chuang Fei Ke Za Zhi, 2002,7(2):41-42
高卫红, 赵向东, 周彩存 . 肿瘤标记物在非小细胞肺癌化疗中的应用价值[J]. 临床肺科杂志, 2002,7(2):41-42
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