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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (1): 51-53.doi: 10.3736/jcim20030121

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Comparative study on immune enhancement effects of four kinds of dodder seeds in Shandong Province

Hui-bin Lin1, Jian-qiang Lin2, Jian-qun Lin2, Ning Lu3, Xiu-yi Yi1   

  1. 1. Shandong Institute of Traditional Chinese Medicine, Jinan, Shandong Province 250014, China
    2. College of Life Sciences, Shandong University, Jinan, Shandong Province 250100, China
    3. Qingdao Shuangjing Pharmaceutical Company, Qingdao, Shandong Province 266000, China
  • Received:2003-03-11 Online:2003-03-20 Published:2018-10-19

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Objective

To compare the effects of immune enhancement, anti-fatigue and anoxia tolerance on mice of four kinds of dodder seeds in Shandong Province.


Methods

Water extracts and alcohol extracts of the four kinds of dodder seeds were administered to mice. The phagocytosis of coelio-macrophage, the weight changes of the immune organs, the survival time to swimming and lacking of oxygen were observed.


Results

The four kinds of dodder seeds in Shandong Province could enhance the phagocytosis of macrophage of mice and increase the weights of thymus and spleen of the immature mice. They could prolong the survival time of mice swimming and lacking oxygen.Cuscuta chinensis Lam. and C. australis R. Br.had better effects than the other two kinds,and the water extracts had better effects than alcohol extracts.


Conclusion

The four kinds of dodder seeds in Shandong Province have the effects of immune enhancement, anti-fatigue and anoxia tolerance. The polysaccharide in dodder seeds is one of the effective materials to improve the immune system.

Key words: dodder, phagocytosis, anti-fatigue, polysaccharide

CLC Number: 

  • R286.95

"

组别 吞噬百分比 脾脏指数 胸腺指数
正常对照 13.33± 2.80 4.88± 1.09 2.53± 0.92
菟丝子水提物 26.17± 4.52** 6.15± 1.91** 4.93±1.22**
南方菟丝子水提物 25.39± 4.31** 6.14± 0.94** 4.78±0.69**
啤酒花菟丝子水提物 23.36± 3.56** 5.94± 1.27** 4.61±1.41**
金灯藤水提物 24.15± 4.02** 6.09± 1.40** 4.70±1.35**
菟丝子醇提物 21.30± 3.73** 5.48± 1.22* 2.91±1.03
南方菟丝子醇提物 20.48± 3.28** 5.52± 1.31* 2.67±0.98
啤酒花菟丝子醇提物 18.43± 3.11* 5.43± 1.07* 3.50±1.05*
金灯藤醇提物 19.52± 3.06* 5.50± 1.21* 3.39±1.08*
菟丝子多糖 17.30± 3.96* 6.11± 0.88** 4.71±1.15**

"

组别 游泳时间（min） 延长率（%）
正常对照 6.01± 1.07 /
菟丝子水提物 10.05± 3.29** 67.22
南方菟丝子水提物 9.85± 3.03** 63.89
啤酒花菟丝子水提物 8.31± 3.18* 38.26
金灯藤水提物 8.50± 2.98* 33.94
菟丝子醇提物 7.58± 2.91 26.12
南方菟丝子醇提物 7.23± 2.69 20.30
啤酒花菟丝子醇提物 7.06± 2.52 17.14
金灯藤醇提物 7.12± 2.77 18.47
菟丝子多糖 6.90± 2.85 14.89

"

组别 耐缺氧时间 （min） 延长率（%）
正常对照 12.82± 1.87 /
菟丝子水提物 23.05± 4.22** 79.80
南方菟丝子水提物 21.71± 4.08** 64.20
啤酒花菟丝子水提物 20.04± 3.90** 56.32
金灯藤水提物 20.19± 3.73** 57.49
菟丝子醇提物 18.30± 3.55** 42.75
南方菟丝子醇提物 18.38± 3.27** 43.37
啤酒花菟丝子醇提物 16.29± 2.63* 27.07
金灯藤醇提物 16.57± 2.75* 29.25
菟丝子多糖 17.66± 3.01* 37.75
[1] 李琳, 丁安伟, 孟丽 . 女贞子多糖的免疫调节作用研究[J]. 中药药理与临床, 2001,17(2):11-12
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