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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (4): 293-295.doi: 10.3736/jcim20030419

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Effect of Chinese and western medicine integration on spinning behavior of rats with Parkinson disease

Jian-cheng He1(), Can-xing Yuan2, Hong-chang Wei1, Ru-xing Chen2   

  1. 1. Department of Traditional Chinese Medicine Diagnosis,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China
    2. Department of Neurology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China
  • Received:2003-03-20 Online:2003-12-20 Published:2003-12-20

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Objective

To observe the effect of Chinese and western medicine integration on the spinning behavior of rats with Parkinson disease.


Methods

Model of the lateral Parkinson disease was made with injection of 6-hydroxydopamine (6-OHDA) into the black substance of the right side of the brain, and the model rats were treated with madopar and Chinese herbs for nourishing the liver and kidney, clearing collaterals and detoxification. The rat's spinning behavior was observed, and was compared with the normal control group, madopar group and sham-operation group at the same time.


Results

Chinese and western medicine integration could obviously reduce the spinning circles of the rats.


Conclusion

Chinese and western medicine integration can significantly improve the spinning behavior of the model rats.

Key words: drugs, Chinese herbal, madopar, Parkinson disease, neurobehavioral manifestations, drug therapy

CLC Number: 

  • R741

"

组别 n 治疗前 治疗后
模型组 19 269.26±98.94 263.05±86.98△△
西药组 20 260.20±59.24 190.90±49.07**▲▲
中西药组 21 254.14±52.79 128.62±32.13**△△▲▲
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