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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (4): 293-295.doi: 10.3736/jcim20030419

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Effect of Chinese and western medicine integration on spinning behavior of rats with Parkinson disease

Jian-cheng He1(), Can-xing Yuan2, Hong-chang Wei1, Ru-xing Chen2   

  1. 1. Department of Traditional Chinese Medicine Diagnosis,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China
    2. Department of Neurology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China
  • Received:2003-03-20 Online:2003-12-20 Published:2003-12-20


To observe the effect of Chinese and western medicine integration on the spinning behavior of rats with Parkinson disease.


Model of the lateral Parkinson disease was made with injection of 6-hydroxydopamine (6-OHDA) into the black substance of the right side of the brain, and the model rats were treated with madopar and Chinese herbs for nourishing the liver and kidney, clearing collaterals and detoxification. The rat's spinning behavior was observed, and was compared with the normal control group, madopar group and sham-operation group at the same time.


Chinese and western medicine integration could obviously reduce the spinning circles of the rats.


Chinese and western medicine integration can significantly improve the spinning behavior of the model rats.

Key words: drugs, Chinese herbal, madopar, Parkinson disease, neurobehavioral manifestations, drug therapy

CLC Number: 

  • R741


组别 n 治疗前 治疗后
模型组 19 269.26±98.94 263.05±86.98△△
西药组 20 260.20±59.24 190.90±49.07**▲▲
中西药组 21 254.14±52.79 128.62±32.13**△△▲▲
[1] 袁灿兴 . 滋补肝肾通络解毒法治疗PD的临床观察[J]. 中医杂志, 2000,42(增):158-160
[2] 袁灿兴 . 滋补肝肾通络解毒法治疗PD的增效减毒作用[J]. 中医杂志, 2000,42(增):160-162
[3] Ungerstedt U . 6-hydroxydopamine induced degeneration of central monoamine neurons[J]. Eur J Pharmacol, 1968,5(1):107-110
[4] 包新民, 舒思云 . 大鼠脑立体定位图谱(第1版)[M]. 北京: 人民卫生出版社, 1991,( 第1版):53
[5] Carman LS, Gage FH, Shults CW . Partial lesion of the substantia nigra: relation between extent of lesion and rotational behavior[J]. Brian Res, 1991,553(2):275-283
doi: 10.1016/0006-8993(91)90835-J
[6] Schwarting RK, Huston JP . The unilateral 6-hydroxydopamine lesion model in behavioral brain research.Analysis of functional deficits,recovery and treatments[J]. Prog Neurobiol, 1996,50(2-3):275-331
doi: 10.1016/S0301-0082(96)00040-8
[7] 田新良, 管兴志, 刘斌 . 神经节苷脂对帕金森病鼠旋转行为、纹状体多巴胺浓度及黑质病理的影响[J]. 中华神经科杂志, 1997,30(4):208-210
doi: 10.1007/s00376-997-0061-6
[8] 陈先文, 陈生弟, 陈红专 . 胶质细胞源性神经营养因子对中脑多巴胺能神经元生物活性观察[J]. 中华神经科杂志, 2001,34(1):62
[9] Fisher A, Bigges CS, Eradiri O , et al. Dual effects of L-3,4-dihydroxyphenylanine on aromatic L-amino acid decarboxylase, dopamine release and motor stimulation in the reserpine-treated rat: evidence that behavior is dopamine independent[J]. Neuroscience, 2000,95(1):97-111
[10] Chase TN, Oh JD . Striatal mechanisms and pathogenesis of Parkinsonian signs and motor complications[J]. Ann Neurol, 2000,47(4 Suppl 1):S122-S130
[11] Henry B, Crossman AR, Brotchie JM . Characterization of enhanced behavioral responses to L-DOPA following repeated administration in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease[J]. Exp Neurol, 1998,151(2):334-342
doi: 10.1006/exnr.1998.6819
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