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Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (5): 478-481.doi: 10.3736/jcim20060507

• Original Clinical Research • Previous Articles     Next Articles

Immunoregulation and short-term therapeutic effects of super-selective intra-arterial chemotherapy combined with traditional Chinese drugs on gastric cancer patients

Jin-shui Zhu,Ming-quan Song,Long Wang, Qun Sun, Li Zhu, Chun Fang   

  1. Department of Gastroenterology, Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2006-09-30 Published:2006-09-15

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Objective

To investigate the immunoregulation and short-term therapeutic effects of super-selective intra-arterial chemotherapy combined with Fuzheng Kang'ai Granules, a compound Chinese herbal medicine, on patients with late gastric cancer.

Methods

Forty patients with late gastric antrum cancer were randomly divided into study group and control group. Patients in the study group were orally administered Fuzheng Kang'ai Granules 48 hours after the first super-selective left gastric artery chemotherapy with high-dose drugs (EAP regime: VP16 100 mg/m2+ epirubicin 60 mg/m2+ carboplatin 200 mg/m2), while patients in the control group were only administered the same local artery chemotherapy as in the study group.

Results

The short-term therapeutic efficacy in the study group and control group were 82.5% and 57.5% respectively (P＜0.01). The occurrence rates of side effects in the study group were significantly lower than those in the control group (P＜0.01). The Karnofsky score of life quality of the study group was obviously higher than that of the control group after treatment (P<0.05). The half survival time and one year survival rate in the study group and control group were (24.9±1.36) month, 70% (28/40) and (13.7±0.72) month, 35% (14/40) respectively. They were significantly improved in the study group compared with the control group (P＜0.01). The levels of cytokines interleukin 2 (IL-2), tumor necrosis factor-α (TNF-α), interferon-gamma (IFN-γ) after treatment in the study group were significantly higher than those before treatment (P<0.05 or P<0.01), as well as than those after treatment in the control group (P＜0.01). On the other hand, the level of immune inhibitory factor soluble interleukin-2 receptor (sIL-2R) after treatment in the study group was lower than that before treatment, as well as than that after treatment in the control group (P<0.01).

Conclusions

The super-selective intra-arterial chemotherapy combined with Fuzheng Kang'ai Granules has good short-term therapeutic efficiency and few side effects for patients with late gastric antrum cancer. It can significantly improve the life quality, extend the survival period, and improve the survival rate in patients with late gastric antrum cancer, which may be due to the up-regulation of the immune regulating factors such as IL-2, TNF-α, IFN-γ and down-regulation of the immune inhibitory factor sIL-2R.

Key words: Arteries, Chemotherapy, Gastric cancer, Cytokines, Traditional Chinese drugs

CLC Number: 

  • R735.2

Table 1

Peripheral blood test in patients with gastric cancer before and 2 weeks after treatment in 2 groups (ヌ±S )"

GroupnWBC (×109/L)HB (g/L)PLT (×109/L)
Study group
Pre-treatment406.3±1.3100.0±10.4141.1±40.8
Post-treatment405.7±1.1*103.4±16.4*125.4±23.1*
Control group
Pre-treatment405.6±1.0109.7±10.8137.6±30.8
Post-treatment403.2±0.689.4±12.186.7±10.9

Table 2

Levels of IL-2, TNF-α, IFN-γ and sIL-2R in peripheral blood before and after treatment in 2 groups (ヌ±S )"

GroupnIL-2 (kU/L）TNF-α （kU/L）IFN-γ （kU/L）sIL-2R （kU/L）
Study group
Pre-treatment4054.7±7.243.1±18.816.6±3.7819.0±104.5
Post-treatment40154.8±10.5 **△△59.4±16.2 *△△54.1±13.4 *△△194.3±67.6 **△△
Control group
Pre-treatment4053.2±6.939.1±14.212.9±3.8840.0±108.2
Post-treatment4049.8±26.329.0±11.110.5±6.2682.4±102.9
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