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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (1): 37-40.doi: 10.3736/jcim20080108

• Original Clinical Research • Previous Articles     Next Articles

Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: A randomized controlled trial

Jun Cai(), Hua Wang, Sheng Zhou, Bin Wu, Hua-rong Song, Zheng-rong Xuan   

  1. Department of General Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
  • Received:2007-07-12 Online:2008-01-20 Published:2008-01-15
  • Contact: CAI Jun E-mail:caijun509@yahoo.com.cn

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Objective: To observe the effect of perioperative application of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation.

Methods:In this prospective, single-blinded, controlled clinical trial, fifty-nine patients with gastric cancer were randomly divided into three groups: control group (n = 20) and two study groups (group A, n = 21; group B,n = 18). Sjunzi Decoction (100 ml) was administered via nasogastric tube to the patients in the study group B from the second postoperation day to the 9th postoperation day. Patients in the two study groups were given an isocaloric and isonitrogonous enteral diet, which was started on the second day after operation, and continued for eight days. Patients in the control group were given an isocaloric and isonitrogonous parenteral diet for 9 days. All variables of nutritional status such as serum albumin (ALB), prealbumin (PA),transferrin (TRF) and T-cell subsets were measured one day before operation,and one day and 10 days after operation.

Results:All the nutritional variables and the levels of CD3 +,CD4 +,CD4 +/CD8 + were decreased significantly after operation. Ten days after operation, T-cell subsets and nutritional variables in the two study groups were increased as compare with the control group. The levels of ALB, TRF and T-cell subsets in the study group B were increased significantly as compared with the study group A (P<0.05). 

Conclusion:Enteral nutrition assisted with Sijunzi Decoction can positively improve and optimize cellular immune function and nutritional status in the patients with gastric cancer after operation.

Key words: stomach cancer, Sijunzi Decoction, T-cell subsets, enteral nutrition, nutritional status

CLC Number: 

  • R735.2

Table 1

Changes of T-cell subsets in three groups ($\bar{x}$±s)"

Group n CD3+ (%) CD4+ (%) CD4+/CD8+
Control group
Before operation 20 66.33±9.57* 42.50±5.53* 1.65±0.37*
1 day after operation 20 50.64±7.20 33.48±4.87 1.39±0.39
10 days after operation 20 55.17±7.20 36.04±4.26 1.41±0.38
Study group A
Before operation 21 66.46±8.33* 42.39±6.51* 1.65±0.34*
1 day after operation 21 51.77±5.20 34.38±5.23 1.35±0.39
10 days after operation 21 60.95±7.77*△ 40.07±6.07*△ 1.50±0.56
Study group B
Before operation 18 71.64±11.36* 44.81±13.06* 1.96±1.11*
1 day after operation 18 58.59±11.08△▲ 28.41±11.87▲ 1.10±0.49△
10 days after operation 18 71.92±13.14*△▲ 48.64±8.80*△▲ 2.24±0.88*△▲

Table 2

Changes of indexes of nutritional status in three groups ($\bar{x}$±s)"

Group n ALB (g/L) PA (mg/L) TRF (g/L)
Control group
Before operation 20 36.03±5.53* 218.80±53.56* 1.93±0.27*
1 day after operation 20 30.80±3.27 171.30±37.95 1.47±0.23
10 days after operation 20 32.61±3.15 186.70±38.80 1.66±0.24*
Study group A
Before operation 21 35.36±3.63* 211.85±43.92* 1.90±0.44*
1 day after operation 21 29.64±2.76 166.47±56.18 1.46±0.22
10 days after operation 21 34.30±1.98*△ 224.85±73.36*△ 1.88±0.34*△
Study group B
Before operation 18 33.58±5.32* 202.86±45.20* 1.81±0.15*
1 day after operation 18 28.62±4.13 155.42±36.56 1.43±0.16
10 days after operation 18 36.23±3.45*△▲ 227.52±39.76*△ 2.09±0.19*△▲
[1] Ye FQ , Chen WW. Pharmacology research of the func tion of Sijunzi Decoction on gastrointestinal tract. Shi Zhen Guo Yi Guo Yao. 2005; 16(1):73-74. Chinese.
doi: 10.3969/j.issn.1008-0805.2005.01.060
叶富强, 陈蔚文 . 四君子汤对胃肠道作用的药理研究. 时珍国医国药. 2005; 16(1):73-74.
doi: 10.3969/j.issn.1008-0805.2005.01.060
[2] Konsman JP, Dantzer R . How the immune and nervous systems interact during disease-associated anorexia. Nutrition. 2001; 17(7-8):664-668.
doi: 10.1016/S0899-9007(01)00602-5 pmid: 11448593
[3] Bozzetti F, Braga M, Gianotti L , et al. Postoperative enteral versus parenteral nutrition in malnourished patients with gastrointestinal cancer : a randomized multicentre trial. Lancet. 2001 ; 358(9292 ): 1487-1492.
doi: 10.1016/S0140-6736(01)06578-3
[4] Wu GH, Wang H, Zhang YW , et al. Effects of an immune-enhancing enteral diet in gastrointestinal cancer patient. Chang Wai Yu Chang Nei Ying Yang. 2003; 10(1):8-11, 14. Chinese with abstract in English.
吴国豪, 王浩, 张延伟 , 等. 消化道肿瘤手术后早期应用免疫增强型肠内营养的作用.肠外与肠内营养. 2003; 10(1):8-11, 14.
[5] Rennie MJ, Smith K, Watt PW . Measurement of human tissue protein synjournal: an optimal approach. Am[J] Physiol. 1994; 266(3 Pt 1):E298-E307.
doi: 10.1111/j.1748-1716.1994.tb09697.x pmid: 8166250
[6] Zhang M, Xia T, Zhang ZH , et al. Effects of Sijunzi decoctum on plasma cytokines in patients with TCM pixu. Di Si Jun Yi Da Xue Xue Bao. 2000; 21(4):411-413. Chinese with abstract in English.
doi: 10.3321/j.issn:1000-2790.2000.04.007
章梅, 夏天, 张仲海 , 等. 四君子汤对脾虚患者血浆细胞因子的影响.第四军医大学学报. 2000; 21(4):411-413.
doi: 10.3321/j.issn:1000-2790.2000.04.007
[7] Wang RJ, Hu YJ, Du Q , et al. Studies of the chemical basis of bidirectional regulation of Sijunzhi Decoction on gastrointestinal motility. Zhong Yao Yao Li Yu Lin Chuang. 2001; 17(6):3-4. Chinese with abstract in English.
doi: 10.3969/j.issn.1001-859X.2001.06.002
王汝俊, 胡英杰, 杜群 , 等. 四君子汤对胃肠运动双向调节作用的物质基础研究( I).中药药理与临床. 2001; 17(6):3-4.
doi: 10.3969/j.issn.1001-859X.2001.06.002
[8] McGowan I, Chalmers A, Smith GR , et al. Advances in mucosal immunology. Gastroenterol Clin North Am. 1997; 26(2):145-173.
doi: 10.1016/S0889-8553(05)70291-0
[9] Cheung NW, Napier B, Zaccaria C , et al. Hyperglycemia is associated with adverse outcomes in patients receiving total parenteral nutrition. Diabetes Care. 2005; 28(10):2367-2371.
doi: 10.2337/diacare.28.10.2367
[10] Zheng JY, Wang WZ, Dong GL , et al. The effect of postoperative immune-enhanced enteral nutrition on immune function in patients with total gastrectomy. Chang Wai Yu Chang Nei Ying Yang. 2007; 14(1):25-27. Chinese with abstract in English.
doi: 10.3969/j.issn.1007-810X.2007.01.007
郑建勇, 王为忠, 董光龙 , 等. 全胃切除病人术后免疫增强型肠内营养的作用.肠外与肠内营养. 2007; 14(1):25-27.
doi: 10.3969/j.issn.1007-810X.2007.01.007
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