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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (7): 695-699.doi: 10.3736/jcim20080707

• Original Clinical Research • Previous Articles     Next Articles

Effects of gastrodin injection on blood pressure and vasoactive substances in treatment of old patients with refractory hypertension: a randomized controlled trial

Qin Zhang1, Yun-mei Yang1(), Guo-you Yu2   

  1. 1. Department of VIP, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310003, China
    2. Department of Traditional Chinese Medicine,the First Affiliated Hospital, School of Medicine,Zhejiang University, Hangzhou, Zhejiang Province 310003, China
  • Received:2007-12-06 Online:2008-07-20 Published:2008-07-15
  • Contact: YANG Yun-mei E-mail:zqdorothy@eyou.com

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Objective: To examine and determine the contents of endothelin (ET) and nitric oxide (NO) in plasma, and to observe the effects of gastrodin injection on blood pressure, ET and NO levels in old patients with refractory hypertension.
Methods: A total of 63 old patients with refractory hypertension, 30 patients with common hypertension and 30 healthy people were included. The contents of ET and NO in plasma of patients in different groups and healthy people were examined and analyzed. The old patients with refractory hypertension were randomly divided into two groups: gastrodin-treated and routine treatment groups. Besides conventional hypotensive drugs, intravenous drip infusion of 1 000 mg gastrodin was administered to the patients in gastrodin-treated group for two courses (4 weeks), while the patients in routine treatment group were treated only with conventional hypotensive drugs. The changes of blood pressure, ET and NO levels before and after treatment in different groups were measured.
Results: The plasma level of ET in refractory hypertension group was higher than that in common hypertension group (t=3.27, P=0.008), while the level of NO was lower (t=–3.81, P=0.002). The systolic pressure and pulse pressure difference in gastrodin-treated group were decreased significantly after one course of treatment (t=1.85, P=0.03; t=1.74, P=0.04). The level of ET in gastrodin-treated group decreased gradually after treatment, but there were no significant difference between before treatment and two courses of treatment, while the level of NO in gastrodin-treated group was increased after treatment (t=–2.70; P=0.04).
Conclusion: Gastrodin injection is beneficial to old patients with refractory hypertension, and can improve the balance of ET and NO levels in plasma.

Key words: gastrodin, aged, hypertension, endothelins, nitric oxide

CLC Number: 

  • R544.1

Table 1

Blood pressure before and after treatment in different groups ($\bar{x}$±s, mmHg)"

Group n Systolic pressure Diastolic pressure Pulse pressure difference
Normal control 30 121.6±10.2 68.7±6.3 52.9±5.8
Common hypertension 30 118.5±7.8 65.3±5.2 53.2±6.1
Refractory hypertention with routine treatment
Before treatment 30 141.8±8.7 73.3±3.8 68.5±6.1
After one course of treatment 30 143.0±10.3 74.1±4.5 68.9±7.6
After two courses of treatment 30 139.3±9.7 71.7±2.9 67.6±8.5
Refractory hypertention with gastrodin treatment
Before treatment 33 147.9±10.1 76.6±5.6 71.3±6.1
After one course of treatment 33 138.3±10.9▲ 72.5±6.0 65.8±6.7▲
After two courses oftreatment 33 135.8±12.3▲ 72.7±6.3 63.1±6.0▲▲

Table 2

Plasma levels of ET and NO before and after treatment in different groups ($\bar{x}$±s)"

Group n ET (ng/L) NO (μmol/L)
Normal control 30 51.8±21.9 71.9±18.9
Common hypertension 30 62.5±23.2* 59.9±20.7**
Refractory herpertension with routine treatment
Before treatment 30 80.1±31.4△△ 42.8±16.3△△
After one course of treatment 30 80.9±25.8 43.7±15.7
After two courses of treatment 30 79.6±27.6 45.0±18.5
Refractory herpertension with gastrodin treatment
Before treatment 33 80.6±23.1△△ 44.2±13.7△△
After one course of treatment 33 77.5±24.6 50.6±18.0
After two courses of treatment 33 70.7±26.8 54.4±16.7▲□
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