Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (7): 695-699.doi: 10.3736/jcim20080707

• Original Clinical Research • Previous Articles     Next Articles

Effects of gastrodin injection on blood pressure and vasoactive substances in treatment of old patients with refractory hypertension: a randomized controlled trial

Qin Zhang1, Yun-mei Yang1(), Guo-you Yu2   

  1. 1. Department of VIP, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310003, China
    2. Department of Traditional Chinese Medicine,the First Affiliated Hospital, School of Medicine,Zhejiang University, Hangzhou, Zhejiang Province 310003, China
  • Received:2007-12-06 Online:2008-07-20 Published:2008-07-15
  • Contact: YANG Yun-mei

Objective: To examine and determine the contents of endothelin (ET) and nitric oxide (NO) in plasma, and to observe the effects of gastrodin injection on blood pressure, ET and NO levels in old patients with refractory hypertension.
Methods: A total of 63 old patients with refractory hypertension, 30 patients with common hypertension and 30 healthy people were included. The contents of ET and NO in plasma of patients in different groups and healthy people were examined and analyzed. The old patients with refractory hypertension were randomly divided into two groups: gastrodin-treated and routine treatment groups. Besides conventional hypotensive drugs, intravenous drip infusion of 1 000 mg gastrodin was administered to the patients in gastrodin-treated group for two courses (4 weeks), while the patients in routine treatment group were treated only with conventional hypotensive drugs. The changes of blood pressure, ET and NO levels before and after treatment in different groups were measured.
Results: The plasma level of ET in refractory hypertension group was higher than that in common hypertension group (t=3.27, P=0.008), while the level of NO was lower (t=–3.81, P=0.002). The systolic pressure and pulse pressure difference in gastrodin-treated group were decreased significantly after one course of treatment (t=1.85, P=0.03; t=1.74, P=0.04). The level of ET in gastrodin-treated group decreased gradually after treatment, but there were no significant difference between before treatment and two courses of treatment, while the level of NO in gastrodin-treated group was increased after treatment (t=–2.70; P=0.04).
Conclusion: Gastrodin injection is beneficial to old patients with refractory hypertension, and can improve the balance of ET and NO levels in plasma.

Key words: gastrodin, aged, hypertension, endothelins, nitric oxide

CLC Number: 

  • R544.1

Table 1

Blood pressure before and after treatment in different groups ($\bar{x}$±s, mmHg)"

Group n Systolic pressure Diastolic pressure Pulse pressure difference
Normal control 30 121.6±10.2 68.7±6.3 52.9±5.8
Common hypertension 30 118.5±7.8 65.3±5.2 53.2±6.1
Refractory hypertention with routine treatment
Before treatment 30 141.8±8.7 73.3±3.8 68.5±6.1
After one course of treatment 30 143.0±10.3 74.1±4.5 68.9±7.6
After two courses of treatment 30 139.3±9.7 71.7±2.9 67.6±8.5
Refractory hypertention with gastrodin treatment
Before treatment 33 147.9±10.1 76.6±5.6 71.3±6.1
After one course of treatment 33 138.3±10.9▲ 72.5±6.0 65.8±6.7▲
After two courses oftreatment 33 135.8±12.3▲ 72.7±6.3 63.1±6.0▲▲

Table 2

Plasma levels of ET and NO before and after treatment in different groups ($\bar{x}$±s)"

Group n ET (ng/L) NO (μmol/L)
Normal control 30 51.8±21.9 71.9±18.9
Common hypertension 30 62.5±23.2* 59.9±20.7**
Refractory herpertension with routine treatment
Before treatment 30 80.1±31.4△△ 42.8±16.3△△
After one course of treatment 30 80.9±25.8 43.7±15.7
After two courses of treatment 30 79.6±27.6 45.0±18.5
Refractory herpertension with gastrodin treatment
Before treatment 33 80.6±23.1△△ 44.2±13.7△△
After one course of treatment 33 77.5±24.6 50.6±18.0
After two courses of treatment 33 70.7±26.8 54.4±16.7▲□
[1] Zhang MX, Du XH, Gao FX . Change of endocrine hormones in patients with refractory hypertension[J]. Gao Xue Ya Za Zhi, 1997,5(2):113-115
张明旭, 杜修海, 高福兴 . 难治性高血压患者内分泌激素的变化[J]. 高血压杂志, 1997,5(2):113-115
[2] 王正荣, 罗红淋, 肖静 , 等. 天麻素对动脉血管顺应性以及血流动力学的影响[J]. 生物医学工程学杂志, 1994,11(3):197-201
Wang ZR, Luo HL, Xiao J , et al. Arterial compliance and hemodynamics parameters response to gastrodin[J]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 1994,11(3):197-201
[3] Lu GP, Wang CQ, Cai ZQ . Pharmacology and clinical research of gastrodin injection[J]. Zhong Cao Yao, 2002,33(5):3-5
吕国平, 王春芹, 蔡中琴 . 天麻素注射液的药理及临床研究[J]. 中草药, 2002,33(5):3-5
[4] Mao GN, Zhang Q, Nie M , et al. The influence of the medicament of gastrodin to rabbit's blood pressure[J]. Shannxi Ke Ji Da Xue Xue Bao, 2003,21(4):50-53
毛跟年, 张嫱, 聂萌 , 等. 天麻制剂对家兔血压的影响[J]. 陕西科技大学学报, 2003,21(4):50-53
[5] Ma XH, Zhang J . Progress of study on the regulation of endothelin and nitrix oxide with Chinese medical herbs[J]. Zhong Xi Yi Jie He Xue Bao, 2004,2(2):152-153, 158
马旭辉, 张杰 . 中药对内皮素及一氧化氮的调控作用研究进展[J]. 中西医结合学报, 2004,2(2):152-153, 158
[6] Wang BX, Dong XM, Guo AM , et al. Effects of Xuefu Zhuyu Decoction on functions of vascular endothelium in patients with unstable angina pectoris[J]. Zhong Xi Yi Jie He Xue Bao, 2006,4(3):256-259
王宝祥, 董雪梅, 郭爱民 , 等. 血府逐瘀汤对不稳定型心绞痛患者血管内皮功能的影响[J]. 中西医结合学报, 2006,4(3):256-259
[7] Gao LR, Liu GZ, Zhao YT , et al. Significance of the basal level of endothelium derived relaxing factor in pathogenesis of hypertension[J]. Zhonghua Nei Ke Za Zhi, 1995,34(5):335-336
高连如, 刘国仗, 赵云涛 , 等. 基础内皮细胞衍生舒张因子水平在高血压发病学上的意义[J]. 中华内科杂志, 1995,34(5):335-336
[8] Taddei S, Virdis A, Ghiadoni L , et al. Endothelial dysfunction in hypertension[J]. J Cardiovasc Pharmacol, 2001,38(Suppl 2):11-14
doi: 10.1097/00005344-200107000-00002
[9] Chen Y, Huang YS . Effects of Jiangya Ⅰ on blood pressure, serum nitric oxide(NO) and endothelin(ET) in spontaneous hypertension rats(SHR)[J]. Zhongguo Zhong Yi Ji Chu Yi Xue Za Zhi, 2006,12(5):364-365
doi: 10.3969/j.issn.1006-3250.2006.05.019
陈颖, 黄永生 . 降压Ⅰ号对自发性高血压大鼠血压、血浆NO及ET的影响[J]. 中国中医基础医学杂志, 2006,12(5):364-365
doi: 10.3969/j.issn.1006-3250.2006.05.019
[1] Shuai Chen, Jin Hu, Deng-cheng Lu, Hong-yi Liu, Shan-shan Wei. Metabolomic characteristics of spontaneously hypertensive rats under chronic stress and the treatment effect of Danzhi Xiaoyao Powder, a traditional Chinese medicine formula. Journal of Integrative Medicine, 2022, 20(1): 73-82.
[2] Rakhi Chakraborty, Swarnendu Roy. Angiotensin-converting enzyme inhibitors from plants: A review of their diversity, modes of action, prospects, and concerns in the management of diabetes-centric complications. Journal of Integrative Medicine, 2021, 19(6): 478-492.
[3] Swatantra Kumar, Vimal K Maurya, Debadatta Nayak, Anil Khurana, Raj K Manchanda, Srinivasulu Gadugu, Madan LB Bhatt, Shailendra K Saxena. Calcarea carbonica treatment rescues lipopolysaccharide-induced inflammatory response in human mononuclear cells via downregulation of inducible cyclooxygenase pathway. Journal of Integrative Medicine, 2020, 18(5): 441-449.
[4] Pranay Soni, Rajesh Choudhary, Surendra H. Bodakhe. Effects of a novel isoflavonoid from the stem bark of Alstonia scholaris against fructose-induced experimental cataract. Journal of Integrative Medicine, 2019, 17(5): 374-382.
[5] Sonia Chew Wen Phang, Uma Devi Palanisamy, Khalid Abdul Kadir. Effects of geraniin (rambutan rind extract) on blood pressure and metabolic parameters in rats fed high-fat diet. Journal of Integrative Medicine, 2019, 17(2): 100-106.
[6] The Su Moe, Htet Htet Win, Thin Thin Hlaing, War War Lwin, Zaw Min Htet, Khin Mar Mya . Evaluation of in vitro antioxidant, antiglycation and antimicrobial potential of indigenous Myanmar medicinal plants. Journal of Integrative Medicine, 2018, 16(5): 358-366.
[7] Byung Hyuk Han, Yun Jung Lee, Jung Joo Yoon, Eun Sik Choi, Seung Namgung, Xian Jun Jin, Da Hye Jeong, Dae Gill Kang, Ho Sub Lee. Hwangryunhaedoktang exerts anti-inflammation on LPS-induced NO production by suppressing MAPK and NF-κB activation in RAW264.7 macrophages. Journal of Integrative Medicine, 2017, 15(4): 326-336.
[8] Omowumi Titilola Kayode, Musa Toyin Yakubu. Parquetina nigrescens leaves: chemical profile and influence on the physical and biochemical indices of sexual activity of male Wistar rats. Journal of Integrative Medicine, 2017, 15(1): 64-76.
[9] Nathalia Gomes Ribeiro de Moura, Ivan Cordovil, Arthurde Sá Ferreira. Traditional Chinese medicine wrist pulse-taking is associated with pulse waveform analysis and hemodynamics in hypertension. Journal of Integrative Medicine, 2016, 14(2): 100-113.
[10] Nouran A. Aleyeidi, Khaled S. Aseri, Shadia M. Matbouli, Albaraa A. Sulaiamani, Sumayyah A. Kobeisy. Effects of wet-cupping on blood pressure in hypertensive patients: A randomized controlled trial. Journal of Integrative Medicine, 2015, 13(6): 391-399.
[11] Kylie Connolly, Douglas Jackson, Candice Pullen, Andrew Fenning. Alpha-adrenoceptor antagonism by Crassostrea gigas oyster extract inhibits noradrenaline-induced vascular contraction in Wistar rats. Journal of Integrative Medicine, 2015, 13(3): 194-200.
[12] Ya Yuwen, Yu-qi Liu, Yan-ping Wang, Jin-gang Dai, Da-sheng Liu, Yue-xi Wang, Xue-jie Han. The add-on effect of a Chinese herbal formula for patients with resistant hypertension: Study protocol for a pilot cohort study. Journal of Integrative Medicine, 2015, 13(2): 122-128.
[13] Vamsi Reddy, Arvind Sridhar, Roberto F. Machado, Jiwang Chen. High sodium causes hypertension: Evidence from clinical trials and animal experiments. Journal of Integrative Medicine, 2015, 13(1): 1-8.
[14] Yong-hong Lian, Mei-xia Fang, Li-guo Chen. Constructing protein-protein interaction network of hypertension with blood stasis syndrome via digital gene expression sequencing and database mining. Journal of Integrative Medicine, 2014, 12(6): 476-482.
[15] Rajendra Karki, Cheol-Ho Park, Dong-Wook Kim. Extract of buckwheat sprouts scavenges oxidation and inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated macrophages (RAW264.7). Journal of Chinese Integrative Medicine, 2013, 11(4): 246-252.
Full text



[1] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[2] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[3] Xi Lin, Jian-ping Liu. Herbal medicines for viral myocarditis. Journal of Chinese Integrative Medicine, 2008, 6(1): 76
[4] Xi Lin, Jian-ping Liu. Tai chi for treating rheumatoid arthritis. Journal of Chinese Integrative Medicine, 2008, 6(1): 82
[5] Liang-ping Hu, Hui Gao. Discrimination of errors in statistical analysis of medical papers published in the first issue of 2006 in Journal of Chinese Integrative Medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 98-106
[6] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035
[7] Wei Xu, Meng Shi, Jian-gang Liu, Cheng-long Wang . Collagen protein expressions in ischemic myocardium of rats with acute myocardial infarction and effects of qi-tonifying, yin-tonifying and blood-activating herbs and detoxifying and blood-activating herbs. Journal of Chinese Integrative Medicine, 2010, 8(11): 1041-1047
[8] Tao Wang , Feng Qin. Effects of Chinese herbal medicine Xiaoyao Powder on monoamine neurotransmitters in hippocampus of rats with postpartum depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1075-1079
[9] Ying Xu , Chang-chun Zeng , Xiu-yu Cai , Rong-ping Guo , Guang Nie , Ying Jin. Chromaticity and optical spectrum colorimetry of the tongue color in different syndromes of primary hepatic carcinoma. Journal of Chinese Integrative Medicine, 2012, 10(11): 1263-1271
[10] Xiang-ying Mao , Qin Bian , Zi-yin Shen. Analysis of the osteogenetic effects exerted on mesenchymal stem cell strain C3H10T1/2 by icariin via MAPK signaling pathway in vitro. Journal of Chinese Integrative Medicine, 2012, 10(11): 1272-1278