[an error occurred while processing this directive]

Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (4): 358-362.doi: 10.3736/jcim20100410

• Original Experimental Research • Previous Articles     Next Articles

Antimotion sickness effects of ginsenosides combined with dexamethasone in rats

 Lin Jia, Wan-yin Wang, Li-mei Zhou, Feng-feng Mo, Min Li   

  1. Department of Military Hygiene, Second Military Medical University, Shanghai 200433, China
  • Received:2010-02-23 Accepted:2010-03-19 Online:2010-04-20 Published:2010-04-15
  • Contact: Min Li E-mail:linlimin115@hotmail.com

Objective

To investigate the antimotion sickness effects of ginsenosides combined with dexamethasone in rats.
Methods

Fifty SD rats were randomly divided into 5 groups: normal saline, scopolamine-treated, ginsenosides-treated, dexamethasone-treated and ginsenosides plus dexamethasone-treated groups. There were 10 rats in each group. The rats in each group were fed with corresponding ingredients respectively, and then the rats were exposed to abnormal acceleration for one hour. The motion sickness index, the level of kaolin consumption and the course and time of spontaneous activity were observed.
Results

The motion sickness index and the level of kaolin consumption of acceleration-exposed rats in ginsenosides plus dexamethasone-treated group were significantly lower than those in normal saline group. And the course and time of spontaneous activity of acceleration-exposed rats in ginsenosides plus dexamethasone-treated group were significantly higher than those in normal saline group. The level of body weight increment of acceleration-exposed rats in ginsenosides plus dexamethasone-treated group was significantly higher than that in dexamethasone-treated group.
Conclusion

Ginsenosides combined with dexamethasone can significantly increase tolerance to acceleration of rats, and the drug combination can decrease side effects of methylprednisolone, such as body weight loss.

Key words: Motion sickness, Panaxosides, Dexamethasone, Scopolamine, Rats

Table 1

Effects of DXMT plus GSS on motion sickness index in acceleration-exposed rats ($\bar{x}$±s)"

Group n Motion sickness index
Before exposure One-day exposure Two-day exposure Three-day exposure
Normal saline 10 1.07±0.91 7.70±1.09** 7.93±2.26** 6.40±1.79**
SPLM-treated 10 1.80±0.97 5.90±1.20** 5.00±1.57** 4.83±0.61**△
DXMT-treated 10 1.09±0.81 6.14±1.75** 4.69±2.19** 4.29±1.74**△
GSS-treated 10 1.28±0.43 7.44±2.01** 7.65±1.96** 7.03±2.04**
GSS plus DXMT-treated 10 1.31±0.94 4.23±1.24** 3.09±1.87** 2.97±1.00**△△▲▲□■■

Table 2

Effects of DXMT plus GSS on kaolin consumption in acceleration-exposed rats ($\bar{x}$±s, g/d)"

Group n Kaolin consumption
Before exposure One-day exposure Two-day exposure Three-day exposure
Normal saline 10 0.69±0.37 4.72±1.59** 3.80±1.27** 3.16±1.26**
SPLM-treated 10 0.83±0.59 2.46±0.82** 1.70±0.79 1.74±0.76△△
DXMT-treated 10 0.67±0.31 1.93±0.62** 2.07±0.72** 1.68±0.66**△△
GSS-treated 10 0.81±0.39 3.50±1.40** 3.13±1.59* 3.01±1.14**▲▲□□
GSS plus DXMT-treated 10 0.77±0.33 2.58±1.63** 1.49±0.93* 1.17±0.60△△▲□■■

Table 3

Effects of DXMT plus GSS on course of spontaneous activity in acceleration-exposed rats ($\bar{x}$±s, cm)"

Group n Course of spontaneous activity
Before exposure One-day exposure Two-day exposure Three-day exposure
Normal saline 10 209.58±51.23 32.60±13.20** 32.13±15.13** 22.60±8.76**
SPLM-treated 10 166.82±64.19 29.78±12.30** 10.98±6.11** 14.44±8.20**△
DXMT-treated 10 177.52±47.34 65.81±25.71** 55.86±11.76** 42.05±17.28**△△▲▲
GSS-treated 10 197.75±59.21 41.38±15.63** 31.15±10.85** 26.68±10.34**▲▲□
GSS plus DXMT-treated 10 200.07±63.42 65.09±48.64** 56.75±45.36** 46.66±19.38**△△▲▲■

Table 4

Effects of DXMT plus GSS on time of spontaneous activity in acceleration-exposed rats ($\bar{x}$±s, s)"

Group n Time of spontaneous activity
Before exposure One-day exposure Two-day exposure Three-day exposure
Normal saline 10 85.65±15.65 6.88±3.53** 4.57±2.39** 2.88±1.82**
SPLM-treated 10 69.73±19.21 9.48±2.89** 1.46±0.74** 1.40±0.62**△
DXMT-treated 10 63.03±18.74 16.94±4.43** 12.80±2.46** 10.33±2.85**△▲▲
GSS-treated 10 82.16±23.44 7.21±2.46** 5.11±1.15** 3.02±1.05**▲□□
GSS plus DXMT-treated 10 75.85±24.57 17.27±8.74** 17.09±10.12** 13.58±3.94**△▲▲■■

Table 5

Effects of DXMT plus GSS on body weight in acceleration-exposed rats ($\bar{x}$±s, g/d)"

Group
n Change of body weight
Before exposure One-day exposure Two-day exposure Three-day exposure
Normal saline 10 6.30±2.41 2.80±1.81** 5.30±4.62 3.20±1.32*
SPLM-treated 10 9.90±8.65 1.50±0.97* 4.80±1.75 3.90±1.85
DXMT-treated 10 9.63±6.12 –(14.75±4.62)** –(10.00±3.02)** –(3.62±1.19)**△△▲▲
GSS-treated 10 8.54±5.03 4.11±1.04 3.27±2.98* 4.67±3.26**□□
GSS plus DXMT-treated 10 7.67±3.81 –(9.56±2.29)** –(6.00±1.94)** 1.56±1.13**△△▲▲□□■■
[1] Ke WQ. Modern ships hygiene[M]. Beijing: People's Military Medical Press, 2005: 540-542
柯文棋 . 现代舰船卫生学[M]. 北京: 人民军医出版社, 2005: 540-542
[2] Kohl RL . Endocrine correlates of susceptibility to motion sickness[J]. Aviat Space Environ Med, 1985,56(12):1158-1165
[3] Kohl RL . Dexamethasone mimicks the antimotion sickness effects of amphetamine and scopolamine[J]. Acta Astronaut, 1986,13(9):565-571
doi: 10.1016/0094-5765(86)90058-5
[4] Otto B, Riepl RL, Klosterhalfen S, Enck P . Endocrine correlates of acute nausea and vomiting[J]. Auton Neurosci, 2006,129(1-2):17-21
doi: 10.1016/j.autneu.2006.07.010
[5] Feng YL, Ling CQ, Zhu DZ, Yu CQ, Chen Z, Li B . Ginsenosides combined with dexamethasone in preventing and treating postembolization syndrome following transcatheter arterial chemoembolization: a randomized, controlled and double-blinded prospective trial[J]. J Chin Integr Med, 2005,3(2):99-102
封颖璐, 凌昌全, 朱德增, 俞超芹, 陈喆, 李柏 . 人参皂苷联合地塞米松防治经动脉化疗栓塞术后综合征的前瞻性双盲随机对照研究[J]. 中西医结合学报, 2005,3(2):99-102
[6] Crampton GH, Lucot JB . A stimulator for laboratory studies of motion sickness in rats[J]. Aviat Space Environ Med, 1985,56(5):462-465
[7] Takeda N, Horii A, Uno A, Morita M, Mochizuki T, Yamatodani A, Kubo T . A ground-based animal model of space adaptation syndrome[J]. J Vestib Res, 1996,6(6):403-409
doi: 10.1016/S0957-4271(96)00071-7
[8] Wang JQ, Cai YL, Chen XM, Tao DY, Fu ZJ, Wang XL, Guo JS . Screen of seasickness behavior indices of simulated seasickness in rats and observation of adaptability rules[J]. Di Er Jun Yi Da Xue Xue Bao, 2009,30(10):1119-1121
王俊骎, 蔡懿灵, 陈新明, 陶懂谊, 付泽建, 王晓黎, 郭俊生 . 模拟晕船大鼠晕船行为学指标的筛选及适应规律的观察[J]. 第二军医大学学报, 2009,30(10):1119-1121
[9] Li M, Zhao FJ . Study progress of traditional Chinese herbal medicine with original adaptation effects[J]. Liaoning Zhong Yi Za Zhi, 1997,24(4):190-191
李敏, 赵法及 . 适应原样中药研究进展[J]. 辽宁中医杂志, 1997,24(4):190-191
[10] Li Y, Li M, Wang X, Hu X, Ling CQ . Experimantal study on the effect of ginsenosides of ginseng stem and leaf in enhancing the transactivation of glucocorticoid receptor induced by dexamethasone in vitro[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2004,24(8):710-713
李勇, 李敏, 王喜, 胡侠, 凌昌全 . 人参茎叶皂甙增强糖皮质激素受体转录激活效应的实验研究[J]. 中国中西医结合杂志, 2004,24(8):710-713
[1] Na Wu , Lu Song , Xin-xin Yang, Jiang-lei Wei , Zhen-guo Liu. Effects of Chinese herbal medicine Tianqi Pingchan Granule on G protein-coupled receptor kinase 6 involved in the prevention of levodopa-induced dyskinesia in rats with Parkinson disease. Journal of Chinese Integrative Medicine, 2012, 10(9): 1018-1024.
[2] Lawrence A. Olatunji, Taofeek O. Usman, Joseph O. Adebayo, Victoria A. Olatunji . Effects of aqueous extract of Hibiscus sabdariffa on renal Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities in Wistar rats. Journal of Chinese Integrative Medicine, 2012, 10(9): 1049-1055.
[3] Dhirender Kaushik, Ajay Kumar, Pawan Kaushik, Avatar C. Rana. Anticonvulsant activity of alcoholic extract of bark of Pinus roxburghii Sarg. Journal of Chinese Integrative Medicine, 2012, 10(9): 1056-1060.
[4] Chan Chen, Chang-xun Chen, Xi-min Wu, Rui Wang, Yi-ming Li. Effects of extracts of Radix Scrophulariae on blood pressure in spontaneously hypertensive rats and the underlying mechanisms. Journal of Chinese Integrative Medicine, 2012, 10(9): 1009-1017.
[5] Jian-sheng Li, Ya Li, Su-yun Li, Yuan-yuan Wang, Li Deng, Yan-ge Tian, Su-li Jiang , Ying Wang. Long-term effects of Tiaobu Feishen therapies on systemic and local inflammation responses in rats with stable chronic obstructive pulmonary disease. Journal of Chinese Integrative Medicine, 2012, 10(9): 1039-1048.
[6] Karuna A. Talpate, Uma A. Bhosale, Mandar R. Zambare. Clitorea ternatea, a herb from Indian folklore, improves streptozotocin-induced diabetes and diabetes-induced cognitive decline in rats. Journal of Chinese Integrative Medicine, 2012, 10(8): 939-947.
[7] Samuel Joshua Pragasam, Vachana Murunikara, Evan Prince Sabina, Mahaboobkhan Rasool. Antiperoxidative potential of p-coumaric acid, a common dietary phenol, in adjuvant-induced arthritis in rats. Journal of Chinese Integrative Medicine, 2012, 10(8): 932-938.
[8] Zi-hui Li, Jian Wang, Rong-lin Cai, You-wen Wang, Jian-peng Hu. Establishment and evaluation of a rat model of ulcerative colitis with syndrome of dampness stagnancy due to spleen deficiency. Journal of Chinese Integrative Medicine, 2012, 10(8): 918-924.
[9] Meng Li, Ling Hu, Rong-lin Cai, Zi-jian Wu, Ke-ming Wang. Effects of electro-acupuncture at PC6 and BL15 on nerve electrical activity in spinal dorsal root and norepinephrine and dopamine contents in paraventricular nucleus of hypothalamus in rats with acute myocardial ischemia. Journal of Chinese Integrative Medicine, 2012, 10(8): 874-879.
[10] Xin-min Li, Hui Chen, Yan-yan Ren, Yan-li Lu. Effects of Chinese herbal medicine Xifeng Capsule on multidrug resistance-associated protein 1 expression in hippocampus and cortex of rats with lithium-pilocarpine-induced epilepsy. Journal of Chinese Integrative Medicine, 2012, 10(8): 911-917.
[11] Hong Wang , Jing-tian Ou , Xin Zhao , Ying Guoz , Hao-ping Mao. Vasodilator effect of oroxylin A on thoracic aorta isolated from rats. Journal of Chinese Integrative Medicine, 2012, 10(8): 880-885.
[12] C. Mouli Kalla, Vijaya Tartte, Dattatreya Rao Sirpurkar. Effectiveness of flavonoid-rich leaf extract of Acalypha indica in reversing experimental myocardial ischemia: biochemical and histopathological evidence. Journal of Chinese Integrative Medicine, 2012, 10(7): 784-792.
[13] Feng Xin-ying, Zhu Min, Zhang Qi-qi, Chen Yi-ping, Li Wen-wei. Selective protection of nigral dopaminergic neurons by echinacoside in a rat model of Parkinson disease induced by rotenone. Journal of Chinese Integrative Medicine, 2012, 10(7): 777-783.
[14] Chuan Chen, Hui-ying Chi, Zhi-hua Yu, Jiu-lin Chen . Effects of Chinese herbal medicine Shoushen Granule on telomere length and telomerase activity of peripheral white blood cells and vascular cells in rats with atherosclerosis. Journal of Chinese Integrative Medicine, 2012, 10(6): 667-673.
[15] Hui-qing Zhang , Zi-fei Yin , Jia-yu Sheng , Zhu-qian Jiang , Bao-yu Wu , Yong-hua Su. A comparison study of pharmacokinetics between bufalin-loaded bovine serum albumin nanoparticles and bufalin in rats. Journal of Chinese Integrative Medicine, 2012, 10(6): 674-680.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. An explanation on "guiding principles of clinical research on mild cognitive impairment (protocol)". Journal of Chinese Integrative Medicine, 2008, 6(1): 15-21
[2] Yi-ting He, Qing-lin Zha, Jian-ping Yu, Yong Tan, Cheng Lu, Ai-ping Lv. Principal factor analysis of symptoms of rheumatoid arthritis and their correlations with efficacy of traditional Chinese medicine and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 32-36
[3] Jun Cai, Hua Wang, Sheng Zhou, Bin Wu, Hua-rong Song, Zheng-rong Xuan. Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(1): 37-40
[4] Wei Zhang, Xiang-feng Lu, Xiao-mei Zhang, Jian-jun Wu, Liang-duo Jiang. A rat model of pulmonary fibrosis induced by infusing bleomycin quickly through tracheal intubation. Journal of Chinese Integrative Medicine, 2008, 6(1): 60-67
[5] A-gao Zhou, Yong Zhang, Gang Kui, De-Yun Kong, Hai-liang Ge, Qiu-hua Ren, Jia-rong Dong, Sheng Hong, Xu-ming Mao, Yin Wang, Hui-zheng Zhang, Shu-jun Wang. Influence of traditional Chinese compound recipes with different efficacy on body weight, tumor weight and immune function in H22 cancer-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 77-82
[6] Guo-hong Yuan, Xiao-jing Pang, He-chao Ma. Synergic effects of Danggui Buxue Decoction in reducing toxicity of cytoxan in tumor-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 83-88
[7] Li Zhou, Hong-xing Zhang, Ling-guang Liu, Wen-jun Wan. Effect of electro-acupuncture at Fenglong (GV 16) on nitric oxide and endothelin in rats with hyperlipidemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 89-92
[8] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. Guiding principles of clinical research on mild cognitive impairment (protocol). Journal of Chinese Integrative Medicine, 2008, 6(1): 9-14
[9] Xin-jun Wang, Ling-ling Wang . A mechanism of endogenous opioid peptides for rapid onset of acupuncture effect in treatment of depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1014-1017
[10] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022
[an error occurred while processing this directive]