Osteoarthritis,Knee,Acupuncture point injection,Placental extracts,Pain,Swelling,Productive time," /> Osteoarthritis,Knee,Acupuncture point injection,Placental extracts,Pain,Swelling,Productive time,"/> Therapeutic effect of acupuncture point injection with placental extract in knee osteoarthritis
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Journal of Integrative Medicine ›› 2017, Vol. 15 ›› Issue (2): 135-141.doi: 10.1016/S2095-4964(17)60316-9

Special Issue: Acupuncture & Moxibustion

• Research Article • Previous Articles     Next Articles

Therapeutic effect of acupuncture point injection with placental extract in knee osteoarthritis

Kyeong Mee Parka, Tae Hwan Chob   

  1. a Inno Oriental Clinic, Daejon 34014, South Korea 
    b Cho Orthopaedic Clinic, Seoul 06643, South Korea
  • Received:2016-09-28 Accepted:2016-11-14 Online:2017-03-15 Published:2017-03-15
  • Contact: Kyeong Mee Park; E-mail: kmpark02@empas.com

Objective

This study evaluated the effectiveness of acupuncture point injection (API) with placental extract on pain reduction and joint function in patients with knee osteoarthritis (OA).

Methods

Fifty-two patients with knee OA, with an average age of 64, and having a symptom duration of more than 3 months were studied in this report. Placental extract was injected weekly into acupuncture point ST35, BL23, BL24 and BL25 for 5 weeks; 8 mL of placental extract into ST35 on the affected side, and 1 mL of placental extract to BL23, BL24 and BL25 bilaterally.

Results

After a five-week treatment of API with placental extract, pain was substantially decreased in patients of all Kellgren-Lawrence (KL) grades. Improvement of knee joint swelling was also apparent. Decrease of pain and joint swelling improved daily working productive time among patients of all KL grades.

Conclusion

Study results imply that API with placental extract is a potentially useful therapy to control pain and maintain joint functions in knee OA patients.

Key words: Osteoarthritis, Knee, Acupuncture point injection, Placental extracts, Pain, Swelling, Productive time

1 Mounsey A, Ewigman B.Arthroscopic surgery for knee osteoarthritis? Just say no.J Fam Pract. 2009; 58(3): 143-145.
2 Raynauld JP, Buckland-Wright C, Ward R, Choquette D, Haraoui B, Martel-Pelletier J, Uthman I, Khy V, Tremblay JL, Bertrand C, Pelletier JP.Safety and efficacy of longterm intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial.Arthritis Rheum. 2003; 48(11): 370-377.
3 Sambrook P, Lane NE.Corticosteroid osteoporosis.Best Pract Res Clin Rheumatol. 2001; 15(3): 401-413.
4 Sambrook PN, Hughes DR, Nelson AE, Robinson BG, Mason RS.Osteocyte viability with glucocorticoid treatment: relation to histomorphometry.Ann Rheum Dis. 2003; 62(12): 1215-1217.
5 Gowri V. An unusual cause of postmenopausal bleeding. BMJ Case Rep.2013; 2013. pii: bcr2012008500.
6 Mens JM, Nico de Wolf A, Berkhout BJ, Stam HJ. Disturbance of the menstrual pattern after local injection with triamcinolone acetonide.Ann Rheum Dis. 1998; 57(11): 700.
7 Rogojan C, Hetland ML.Depigmentation—a rare side effect to intra-articular glucocorticoid treatment.Clin Rheumatol. 2004; 23(4): 373-375.
8 Whitworth JA, Gordon D, Andrews J, Scoggins BA.The hypertensive effect of synthetic glucocorticoids in man: role of sodium and volume.J Hypertens. 1989; 7(7): 537-549.
9 Feldman-Billard S, Du Pasquier-Fediaevsky L, Héron E. Hyperglycemia after repeated periocular dexamethasone injections in patients with diabetes.Ophthalmology. 2006; 113(10): 1720-1723.
10 Cao L, Zhang XL, Gao YS, Jiang Y.Needle acupuncture for osteoarthritis of the knee: a systematic review and updated meta-analysis.Saudi Med J. 2012; 33(5): 526-532.
11 Manheimer E, Cheng K, Linde K, Lao L, Yoo J, Wieland S, van der Windt DA, Berman BM, Bouter LM. Acupuncture for peripheral joint osteoarthritis. Cochrane Database Syst Rev.2010; (1): CD001977.
12 Cho TH, Park KM.Complex regional pain syndrome type 1 relieved by acupuncture point injections with placental extract.J Acupunc Meridian Stud. 2014; 7(3): 155-158.
13 Cho TH, Park KM.Use of acupuncture point injection with placental extract for treatment of complex regional pain syndrome.Pain Relief. 2016; 5: 246.
14 Guermazi A, Hayashi D, Roemer F, Felson DT, Wang K, Lynch J, Amin S, Torner J, Lewis CE, Nevitt MC.Severe radiographic knee osteoarthritis—does Kellgren and Lawrence grade 4 represent end stage disease?—the MOST study.Osteoarthritis Cartilage. 2015; 23(9): 1499-1505.
15 Guermazi A, Hayashi D, Roemer FW, Felson DT.Osteoarthritis: a review of strengths and weaknesses of different imaging options.Rheum Dis Clin North Am. 2013; 39(3): 567-591.
16 Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, Gabriel S, Hirsch R, Hochberg MC, Hunder GG, Jordan JM, Katz JN, Kremers HM, Wolfe F; National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II.Arthritis Rheum. 2008; 58(1): 26-35.
17 Chen X, Spaeth RB, Retzepi K, Ott D, Kong J.Acupuncture modulates cortical thickness and functional connectivity in knee osteoarthritis patients.Sci Rep. 2014; 4: 6482.
18 Raeissadat SA, Rayegani SM, Hassanabadi H, Fathi M, Ghorbani E, Babaee M, Azma K.Knee osteoarthritis injection choices: platelet rich plasma (PRP) versus hyaluronic acid (a one-year randomized clinical trial).Clin Med Insights Arthritis Musculoskelet Disord. 2015; 8: 1-8.
19 Wang F, He X.Intra-articular hyaluronic acid and corticosteroids in the treatment of knee osteoarthritis: a meta-analysis.Exp Ther Med. 2015; 9(2): 493-500.
20 Yeom MJ, Lee HC, Kim GH, Lee HJ, Shim I, Oh SK, Kang SK, Hahm DH.Anti-arthritic effects ofEphedra sinica STAPF herb-acupuncture: inhibition of lipopolysaccharideinduced infl ammation and adjuvant-induced polyarthritis. J Pharmacol Sci. 2006; 100(1): 41-50.
21 Marx C, Silveira MD, Selbach I, da Silva AS, Braga LM, Camassola M, Nardi NB. Acupoint injection of autologous stromal vascular fraction and allogeneic adipose-derived stem cells to treat hip dysplasia in dogs.Stem Cells Int. 2014; 2014: 391274.
22 Kwon YB, Lee JD, Lee HJ, Han HJ, Mar WC, Kang SK, Beitz AJ, Lee JH.Bee venom injection into an acupuncture point reduces arthritis associated edema and nociceptive responses.Pain. 2001; 90(3): 271-280.
23 Wang M, Gao YH, Xu J, Chi Y, Wei XB, Lewith G, Liu JP.Zusanli (ST36) acupoint injection for preventing postoperative ileus: a systematic review and meta-analysis of randomized clinical trials.Complement Ther Med. 2015; 23(3): 469-483.
24 Zhu YH, Chen YH.On effects of acupoints and drugs in acupoint-injection treatment.Zhongguo Zhen Jiu. 2005; 25(1): 46-48.
25 Bijkerk C, Houwing-Duistermaat JJ, Valkenburg HA, Meulenbelt I, Hofman A, Breedveld FC, Pols HA, van Duijn CM, Slagboom PE. Heritabilities of radiologic osteoarthritis in peripheral joints and of disc degeneration of the spine.Arthritis Rheum. 1999; 42(8): 1729-1735.
26 Günther KP, Stürmer T, Sauerland S, Zeissig I, Sun Y, Kessler S, Scharf HP, Brenner H, Puhl W.Prevalence of generalised osteoarthritis in patients with advanced hip and knee osteoarthritis: the Ulm Osteoarthritis Study.Ann Rheum Dis. 1998; 57(12): 717-723.
27 Takahashi Y, Ohtori S, Takahashi K.Dorsoventral organization of sensory nerves in the lumbar spine as indicated by double labeling of dorsal root ganglion neurons.J Orthop Sci. 2010; 15(4) 578-583.
28 Ashton IK, Ashton BA, Gibson SJ, Polak JM, Jaffray DC, Eisenstein SM.Morphological basis for back pain: the demonstration of nerve fibers and neuropeptides in the lumbar facet joint capsule but not in ligamentum fl avum.J Orthop Res. 1992; 10(1): 72-78.
29 Chen CY, Lin CN, Chern RS, Tsai YC, Chang YH, Chien CH.Neuronal activity stimulated by liquid substrates injection at Zusanli (ST36) acupoint: the possible mechanism of aquapuncture.Evid Based Complement Alternat Med. 2014; 2014: 627342.
30 Yeom MJ, Lee HC, Kim GH, Shim I, Lee HJ, Hahm DH.Therapeutic effect ofHominis placenta injection into an acupuncture point on the infl ammatory responses in subchondral bone region of adjuvant-induced polyarthritic rat. Biol Pharm Bull. 2003; 26(10): 1472-1477.
31 Kim JK, Kim TH, Park SW, Kim HY, Kim SH, Lee SY, Lee SM.Protective effects of human placenta extract on cartilage degradation in experimental osteoarthritis.Biol Pharm Bull. 2010; 33(6): 1004-1010.
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